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Biomedical subjects

E M Critchley

Publications and source records attributed to E M Critchley.

47 records · Page 3Linked to original sources
PubMed1976

Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants.

In a study of chronic epileptics in a residential centre we recorded a 56% incidence of Dupuytren's disease. The lesions were usually bilateral and symmetrical and frequently associated with knuckle pads and plantar nodules. There was no direct relationship between Dupuytren's disease and frozen shoulder. Dupuytren's disease was seen equally in those with idiopathic or symptomatic epilepsy. The incidence increased with the duration of epilepsy and is probably a sequel to long-term administration of phenobarbitone. Reasons are given for presuming that the association between Dupuytren's disease and antiepileptic therapy is mediated through the peripheral stimulation of tissue growth factors and not through the central release of growth hormone or through alterations in liver metabolism.

Adult↗
PubMed1975

Control of epilepsy with a single daily dose of phenytoin sodium.

Fifty-three patients in an epileptic centre have been studied. All were receiving phenytoin and many were also receiving other antoconvulsant drugs. 2. Thirty-six patients took part in a three month cross over study. There was no significant change in the frequency of epileptic seizures or in the late morning serum concentration of phenytoin when the treatemtn was changed from two to three spaced doses of phenytoin sodium/day to a single dose at 12.00 hours. 3. Seventeen patients acted as a control group. They received phenytoin sodium as two or three spaced doses/day throughout the study. There was no significant change in the frequency of epileptic seizures or in the late morning serum concentration of phenytoin between the first and second three month periods of observation. 4. It is concluded that the total daily dose of phenytoin sodium may be given once daily without reduction of the anticonvulsant effect.

Adolescent↗
PubMedDate not supplied

Charcot's hysteria renaissant.

The authenticity of Charcot's original descriptions of hysteria has been questioned in the popular media. None the less, it is still possible to encounter florid forms of hysteria in culturally deprived communities, and to answer Charcot's present day critics we present a selection of patients from Kentucky's Appalachian countries with hysterial neurological disease. Their case histories are contrasted with those Charcot himself described and thereby form a modern commentary on such conditions as la grande hystérie, hysteroepilepsy, hysterotraumatic monoplegia, and hysterical hemianaesthesia.

Adolescent↗