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Biomedical subjects

E Lejeune

Publications and source records attributed to E Lejeune.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Mast cells in bone pathology].

The authors have endeavoured to determine the place occupied by mast cells in bone tissue from the mode of action on the bone of their secretion products (metachromatic granules, heparin, prostaglandins), from their proliferation in reaction to some bone diseases (secondary mastocytosis) and from the bone lesions associated with systemic mastocytosis. Metachromatic granules are capable of chelating calcium, and heparin and prostaglandins stimulate bone resorption. However, the role of mast cells in bone remodeling through these mechanisms has not yet been demonstrated. Similarly, the significance of mastocytosis secondary to osteomalacia, renal osteodystrophy and ordinary osteoporosis remains hypothetical. Primary bone mastocytosis produces diffuse or circumscribed osteogenic, osteolytic or mixed lesions. While the pathogenesis of osteolytic forms can readily be explained by the actions of heparin and prostaglandins, that of the osteogenic forms is still mysterious. Finally, the histological profile, and even the nosological profile, of mast cell osteoporosis, a diffuse condition recently individualized, remain undetermined.

Bone Diseases↗
PubMed1982

[Value of anti hemolysin and anti-gammahemolysin assays for the diagnosis of staphylococcal infections, particularly of osteoarthritis (author's transl)].

The authors report the results of more than twelve years' personal research on the value of anti-alphahemolysin (AASTL) and antigammahemolysin (AGSTL) assays for the diagnosis of staphylococcal infections, and particularly of osteoarthritis. Among 574 controls, AASTL levels exceeded 2 IU in only 14 subjects (11 of these, levels were between 2 and 3 IU). Levels less than, or equal to, 2 IU were therefore considered normal. This is consistent with previously published data. In 144 staphylococcal infections, confirmed by bacteriology, an increase in AASTL was found in 95 of all cases (65.9%) and in 54 of the 76 osteoarthritis' (71%). Similarly, AGSTL titres, which were under 1/160 (upper normal limit) in 138 controls, were increased in 35 patients with unequivocal staphylococcal infections (61.4%), and in 25 of 36 patients with osteoarthritis (69.4%). These results show that AASTL assay is reliable and often abnormal. However, assay of both hemolysins yields even better results. This dual assay was performed in 57 patients with staphylococcal infection. One hemolysin at least was increased in 47 patients (82.4%). This represents additional positivity in 15.7% of patients when compared to AASTL assay alone, and in 21% when compared to AGSTL assay alone. The high level of positive results with dual assay is even more striking when only staphylococcal osteoarthritis is considered: one or both hemolysins were increased in 91.1% of these patients (31/34).

Antibodies, Bacterial↗
PubMed1982

[Total right hemispherectomy: neurophysiological study after twenty-six years].

Twenty-six years after a total right hemispherectomy for tumor when thirteen years old, a right-handed patient presented with disturbances of equilibrium, urinary incontinence, and a marked reduction in motor impulses, in spite of a subnormal intelligence quotient (0.85). Computed tomography examinations suggested the presence of a normal pressure hydrocephalus. However intracranial pressure monitoring and isotopic and cerebrospinal fluid perfusion tests showed the absence of any cerebral obstruction, and free communication between the cerebral and spinal spaces, though intracranial volume capacity accommodation was greatly reduced. Clinical examination demonstrated good quality sensory appreciation by the left half of the body, the possibility of detecting an object in the visual hemifield supposedly blind, and perfect location of a sound source. Somesthetic evoked potentials were studied by stimulating the median nerve in the left and right wrist regions. Left hemisphere evoked potentials from a contralateral stimulus, were of normal latency, amplitude and morphology, the response to an ipsilateral stimulus also presenting an early potential component (N 26 starting at N 21). This exceptional finding in a hemispherectomized patient could be related to activity of the spinoreticulothalamic tracts in the lemniscal or extralemniscal systems. Auditory function tests demonstrated perfect stereoaudiometry and the quality of perception during dichotic listening tests. Auditory evoked potentials in the brain stem included only minor functional-type anomalies, with slightly increased latencies in the pons on the left, and the mesencephalon and pons on the right. The presence of a bilateral wave VI was related to activity of the median geniculate pathway. Visual function tests showed good quality left photomotor reflexes and positive object detection in the anopsic hemifield. Results of these tests were reproducible during the same examination and after an interval of several months. The relevant literature is reviewed.

Adolescent↗
PubMed1981

[Plasmatic and urinary zinc in rheumatoid arthritis (author's transl)].

The analysis of the plasmatic and urinary levels of zinc in 50 patients presenting a non inflammatory disease and in 50 rheumatoid arthritis, points out to an high significative difference between plasmatic data (13,37 +/- 2,72 mumol/l and 11,32 +/- 2,22 mumol/l respectively ; p less than 0,001). No difference was found in urinary levels and neither age, nor sex, duration of the disease, most biologic parameters, nor long term medications can explain the difference which seems related to the inflammatory tissue process.

Adult↗
PubMed1981

[Medical treatment of osteoarticular tuberculosis].

The authors report 45 personal cases observed over the last ten years, from a series of 520 cases collected during a multi-centre enquiry of the French Society of Rheumatology and a review of the literature; they discuss the present tendencies in the treatment of bone and joint tuberculosis. Antibiotic and chemotherapy uses drugs which are more and more effective, easier and easier to manipulate, ensuring in almost all cases a lasting cure with frequent conservation of joint function, shortening the natural course of the disease, and preventing or curing its complications. The role of surgery thus becomes more restricted, the period of rest may be shortened and it may becomes less strict in many cases; on the other hand, physiotherapy is becoming more important in this treatment. As for the possibility of shortening antibiotic therapy, and although the experience obtained from lung tuberculosis is encouraging, the absence of comparably large series in bone and joint tuberculosis should make one circumspect.

Antibiotics, Antitubercular↗
PubMed1981

[Vitamin-sensitive osteomalacia in condensing bone metastases of prostatic origin. Apropos of 2 cases].

In connection with two observations histologically proved on a metastasic territory of osteomalacia appeared during osteocondensing metastases of prostatic origin, the authors underline the responsibility of sudden increase of osteoformation in the hypocalcemia genesis and put the emphasis on the transitory aggravating function of the given high doses of estrogen within negative calcium balance. A D vitamin deficiency, frequent among old patients, could increase osseous manifestation of calcium supply insufficiency responsible of an authentic osteomalacia. This deficiency is not secondary to a phosphorus diabetes and is amended by an important calciu addition and by the administration of D vitamin metabolites as proved by repeated osseous biopsy with dynamic and histomorphometric studies.

Aged↗
PubMed1981

[HLA and rheumatoid arthritis].

In a study on the frequency of the HLA A, B, C and DR antigens seen in 100 controls and 31 patients with rheumatoid arthritis, the authors found a significant increase in the DR4 antigen in rheumatoid arthritis. (50% as against 25%; X2 = 8,5; 0,04 greater than Pc greater than 0,008; RR = 3,43). The other antigens on loci A, B. C and DR are not altered significantly. However the increase in DR4 which does not seem to be related to the severity of the rheumatoid arthritis, seems to be proportional to the level of rheumatoid factor. The authors review literature on HLA in rheumatoid arthritis and the figures for the antigenic frequency of HLA-DR4 are compared with their own results. The findings are of interest especially from a pathogenic point of view.

Adult↗
PubMed1980

[Pseudopottic and pseudodystrophic forms of spondylodiscites of ankylosing spondylitis. Four personal cases and 20 observations from the literature].

On the basis of four personal cases and of 20 cases taken from the literature, the authors outline the radioclinical aspects of the pseudo-pottic forms of ankylosing spondylitis and distinguish, aside from forms very closely resembling a microbial lesion, pseudodystrophic forms whose appearance is very close to that of intraspongious hernias.

Adult↗
PubMed1979

Pharmacokinetics of fenbufen in man.

The pharmacokinetics of fenbufen (3,4-biphenylcarbonyl proprionic acid) a new antiinflammatory agent, and its metabolites, gamma-hydroxy-4-biphenylbutyric acid and 4-biphenylacetic acid have been studied after oral administration to seven patients with rheumatoid arthritis. Fenbufen was administered as a single oral dose of 600 mg in hard gelatine capsules. A specific, sensitive gas chromatographic method was used to measure the concentration of the three compounds. A linear two-compartment open model appeared suitable to describe the course of the plasma level of fenbufen with time. This compound appeared in the blood after a lag time of 0.45 h and the peak plasma concentration of 5.97 micrograms/ml was observed after 1.19 h. The half-life of plasma disappearance was 10.26 h for fenbufen and 10.07 h and at 9.95 for metabolites II and III, respectively.

Adult↗
PubMed1979

[Disfiguring ulcer forms of the carpal tunnel syndrome].

On the basis of 3 personal cases and 13 cases in the literature, the authors carried out a study of these rare forms of the carpal tunnel syndrome. The syndrome itself generally has a unique character marked on the etiologic level by a frequent occurrence of unilateral and post-traumatic forms, and on the clinical level by the existence of severe sensitivo-motor, vasomotor and trophic problems; it rarely resembles Raynaud's syndrome. The cutaneous lesion most often appears as a torpid ulceration located on the forefinger and/or the second finger and involving the palmar surface or the sub-ungual region of the 3rd phalanx. Cutting of the ligament of the middle finger, whether or not accompanied by an additional surgical act, is almost always followed by a regression of the classical signs and the curing of the ulcerations.

Aged↗