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Biomedical subjects

E Lejeune

Publications and source records attributed to E Lejeune.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Relation between the cellularity and lactic acid level in 55 synovial fluids and research on concentration profile as a function of the etiology].

The authors investigated 55 determinations of synovial lactic acid in 7 groups of patients: septic arthritis, seropositive rheumatoid arthritis, seronegative rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitic arthritis, reactive arthritis, mechanical fluids of osteoarthritis. Statistical analysis confirmed the diagnostic contribution of this determination in septic arthritis and demonstrated a correlation between the lactic-acid and cell levels within a cell-level range of 5,000-20,000. A significant difference was detected between seronegative and seropositive forms of arthritis. The physiopathologic interpretation of the findings in cases of rheumatoid polyarthritis and in non-rheumatoid inflammatory rheumatism is discussed.

Anaerobiosis↗
PubMed1985

[Otoneurosurgical treatment of tumors of the cerebellopontine angle. Apropos of a series of 93 cases].

Authors analyse their experience with the treatment of ninety-three cases of cerebello-pontine angle tumors. A trained team with an otologist and neurosurgeon can obtain best results, both functional and vital. The postero-trans-labyrinthine approach, as described by House and al is used ad the method of choice. Analysis of cases shows that big tumors are frequent and their therapy difficult even if the risk of mortality has been diminished.

Adolescent↗
PubMed1984

[Ankylosing spondylarthritis. Pathogenesis of the destructive disco-vertebral lesions. 15 cases].

Fifteen cases of destructive disco-vertebral lesions discovered in patients with ankylosing spondylitis are reported. The incidence of these lesions was 5.5% and they were unrelated to underlying conditions. Radiologically, they fell into five categories: pseudodystrophic, pseudotuberculous, extensive erosions, bone condensation and isolated narrowing of the intervertebral spaces. From an analysis of these 15 cases and of published data, it would appear that these forms result from different pathogenetic processes: an inflammatory process for the pseudodystrophic and pseudotuberculous forms and for early extensive erosions; a mechanical process for bone condensation and perhaps also (though this is more controversial) for late extensive erosions and isolated intervertebral narrowing.

Adolescent↗
PubMed1984

Immunoelectrophoretic investigations in 55 patients with systemic amyloidosis.

Among 55 amyloidoses, the detection of a monoclonal protein (MP) led to the selection of 15 primary and 3 myeloma-associated types of amyloidosis. Therefore the presence of a MP gives evidence for an immunocytic amyloidosis. The lambda-light-chain nature of MP and the abundant production of free light-chains are two of the factors predisposing to the production of amyloid deposits (AL) in the course of immunocyte dyscrasias.

Amyloid↗
PubMed1984

Increased DNA and/or RNA content of synovial fluid cells in rheumatoid arthritis: a flow-cytometry study.

Flow-cytometry studies of DNA and RNA content were carried out in acridine orange-stained synovial fluid lymphocytes from 11 patients presenting with classical or definite rheumatoid arthritis. Monoclonal antibodies were used to detect specific T cell surface antigens (OKT3, OKT4, OKT8) and antigens associated with lymphocyte activation (OKIa 1, OKT10). T3 positive cell percentages were comparable to those of normal blood, although T4/T8 ratios were decreased in 4 out of 5 cases, and HLA-DR positive cells increased. Six out of 11 patients showed percentages of dividing cells varying from 2.2 to 7.2% as compared with less than 1% in the other patients and in normal blood. Nondividing cells were characterised by an increase in their RNA content compared with normal blood. A greater increase of RNA content was observed in patients with lower percentages of dividing cells, suggesting a G1/S block. Changes in cellular DNA and/or RNA contents provide a valuable parameter of lymphocyte activation, not necessarily linked to the expression of differentiation antigens by activated cells.

Adolescent↗
PubMed1984

[Cytofluorometric study of the cell cycle and various lymphocyte differentiation membrane antigens in the synovial fluid in rheumatoid polyarthritis].

Synovial fluid lymphocytes were studied by cytofluorometry in 11 patients with classical or definite rheumatoid arthritis. This method allowed the study of the cellular cycle after acridine orange staining and of membrane antigens, expressed by normal and/or activated lymphocytes, which were demonstrated by using various monoclonal antibodies (OKT3, OKT4, OKT8, OKIa1, OKT10). The OKT4/OKT8 ratio was decreased in 4 out of 5 cases and the percentage of HLA DR + cells was clearly increased. In 6 out of the 11 patients, the percentage of dividing cells varied from 2.2 to 7.2 and was less than 1 in the others as in normal blood lymphocytes. Increase in cellular RNA content characterized the non dividing cells. The most elevated values of the cellular RNA content were observed in patients who had the smallest percentage of dividing cells, suggesting that the cellular cycle was stopped between the G1 and S phases. Study of the cellular cycle may reveal a lymphocyte activation parameter which could be unrelated to the expression of differentiation membrane antigens.

Adolescent↗
PubMed1983

Chronopharmacokinetic study of a prolonged release form of indomethacin.

The chronopharmacokinetics of indomethacin was studied in patients with rheumatoid diseases after a single oral dose of a new prolonged-release form containing indomethacin 75 mg. The drug was given either at 8, 12 or 20 h and its plasma concentrations, as well as those of its main metabolite, O-desmethyl indomethacin, were followed using a new specific gas chromatographic assay. When given at 20 h plasma indomethacin concentrations did not exhibit a sharp peak and remained much more stable than when the drug was given at 8 or 12 h. In addition, plasma O-desmethyl indomethacin was significantly higher after administration of indomethacin at 20 h than at 8 or 12 h. It is concluded that the pharmacokinetics of the oral prolonged-release form of indomethacin exhibited chronobiological variation. The data are in accordance with clinical studies which suggest that it might be worthwhile to administer this formulation of indomethacin at 20 h.

Adult↗
PubMed1983

[Treatment of rheumatoid arthritis with isoprinosine. Personal experience].

Twenty patients with classical or proved rheumatoid arthritis were treated with Isoprinosine. 13 patients received a dose of 25 mg/kg/day and 7 received a dose of 50 mg/kg/day, continuously for 2 months and then discontinuously, 5 days every fortnight. The series being treated with 25 mg/kg/day (7 patients) have received treatment for 12 months. No side effects have been observed; the only reason for ceasing treatment was its ineffectiveness (after at least 3 months of administration). The dosage of the associated anti-inflammatory drugs did not need to be increased, but neither was it decreased. The authors conclude that Isoprinosine is largely ineffective clinically, on laboratory tests and in terms of immunology, at least with the therapeutic protocols tested here.

Adult↗
PubMed1983

[Erbium 169 synoviortheses and infiltrations of triamcinolone hexacetonide in metatarsophalangeal arthritis of chronic inflammatory rheumatism].

The authors report their experience in the treatment of metatarsophalangeal arthritis of chronic inflammatory rheumatism by Erbium 169 synoviortheses (112 joints treated) and by infiltrations of triamcinolone hexacetonide (53 joints treated). The steroid appears to have a marked early superiority as it gives 85% good results compared to 61.6% for Erbium 169 after a period of one to three months. However, its results then deteriorate more rapidly and after 6 months, the proportion of good results is greater with the radioactive treatment (64% compared to 46.7%). The authors consider it reasonable to use triamcinolone hexacetonide as the first line treatment as it is easier to manage and less expensive, reserving the radioactive synoviortheses for later with the prospect of more lasting results.

Adult↗
PubMed1982

[Distal bone metastases of the upper limb].

This work is based on a review of 120 peripheral bone metastases of the upper limbs found in the literature and 10 others selected from a personal series of 469 cases of bone metastases. The authors stress the scarcity of these lesions (2%), metastases arising in bones of the forearm are usually part of a widespread osseous involvement, generally of mammary or prostatic origin. Metastases to the bones of the hand are more peculiar: 1) Those from bronchogenic carcinoma account for 50%. 2) Resultant soft tissue necrosis creates swelling, redness, heat and pain, which can mimic acute osteomyelitis. 3) X-rays reveal isolated osteolysis affecting metacarpals, phalanges, or more rarely carpal bones. Distal location of those metastases does not modify therapeutic management amputation is the best effective palliative treatment and must be discussed every time there is a concomitant skin ulceration, or if bone metastasis is unique or if the primary tumor is cured or accessible to treatment.

Aged↗