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Biomedical subjects

E Lee

Publications and source records attributed to E Lee.

At least 451 records · Page 25Linked to original sources
PubMed1981

Angiosarcoma of the heart: ultrastructural study.

Two angiosarcomas of the heart, both arising from the right atrium, were studied with the electron microscope. Ultrastructural characteristics of angiomatous development were demonstrated both at the better differentiated vascular areas and at the less differentiated, spindle-cell foci. Both tumors were dominated by immature endothelial cells. These cells were associated with primitive mesenchymal cells and transitional forms of pericytes. Intracytoplasmic lumen formation and junctional specialization with neovascular development are unique features of angiogenesis in these tumors. Ultrastructural studies may provide useful diagnostic features separating a true malignant vascular neoplasm of endothelial cell origin from other forms of mesenchymal neoplasia that may have a prominent stromal vascular component.

Adult↗
PubMed1981

Dicentric isochromosome for the long arm of chromosome #17, dic i(17q), in a patient with chronic myelogenous leukemia (CML).

Cytogenetic studies in a 33-year-old male patient with chronic myelogenous leukemia of 7 years duration revealed a so-called i(17q) chromosome marker and other cytogenetic abnormalities during the early phase of blastic crisis which were not present at diagnosis. Careful morphologic examination of this marker using G- and C-banding techniques revealed it to be a dicentric chromosome with a very short intercentromeric area. The fact that the dicentric nature of this marker was not apparent with the conventional Giemsa stain emphasizes the usefulness of the C-banding technique in defining the origin of this important cytogenetic marker.

Adult↗
PubMed1981

Orthotopic bone transplantation in mice. III. Methods of reducing the immune response and their effect on healing.

Various methods of reducing the immune response to allogeneic bone grafts, either by pretreating the graft or by immunosuppressing the recipient, were compared. Tibial grafts from B10.D2 mice, either untreated or pretreated in various ways, were transplanted into B10 recipients. The antibody response was followed and the extent of bone healing at 4 months was assessed. Pretreatment of the graft by X-irradiation, freezing, or by incubation in alloantisera (either anti-H-2 or anti-Ia) reduced or abolished the immunogenicity of the graft. Immunosuppression of the recipient with methotrexate or antilymphocyte serum (ALS) also greatly depressed the antibody response. But when healing was assessed, none of these treatments except ALS improved the delayed healing of the bone allografts. The reason for this failure was probably that X-irradiation, freezing, alloantiserum pretreatment, and methotrexate all interfered with bone healing directly, whereas ALS did not. We conclude that many methods will reduce the immune response to allogeneic bone, but that only ALS will improve the healing of the allogeneic bone. Furthermore, as a corollary to the observation that pretreatment with anti-Ia serum markedly reduced the immunogenicity of bone allografts, we conclude that much of the immunogenicity of bone allografts is attributable to a population of Ia-positive cells.

Animals↗
PubMed1979

Circannual variation and genetic regulation of hepatic testosterone hydroxylase activities in inbred strains of mice.

Hydroxylation of testosterone by hepatic microsomes at positions 6 alpha, 6 beta, 7 alpha, 15 alpha, and 16 alpha has been studied in C57BL/6J, 129/J, and A/J mice. Differences in hydroxylase activities between the C57BL/6J and A/J strains and between the C57BL/6J and 129/J strains were investigated using standard genetic breeding protocols. In the C57BL/6J X A/J line, 6 alpha- and 7 alpha-hydroxylase activity appeared to be under polygenic control in both sexes, as did 15 alpha-hydroxylase activity in females. The lack of 16 alpha-hydroxylase activity observed in 129/J females behaved as a recessive, autosomal, single locus, sex-limited trait. In several instances, the level of hydroxylase activity at one position appeared to be affected by the level of hydroxylase activity at a second position; however, no clear-cut pattern was discerned. Over a period of a year, a remarkable cycle in total hydroxylase activity for all mice was observed; the average activity was greatest in December and least in April.

Animals↗
PubMed1979

Increase of brain taurine contents of E1 mice by physiological stimulation.

We determined the effect of physiological stimulation on taurine contents in three regions (cerebral cortex, brain stem and cerebellum) of the brain of E1 mice, a genetically epileptic strain. Taurine contents in all regions of the brain increased significantly at the onset of convulsions, as induced by tossing the animals up many times. Levels in the cerebral cortex and cerebellum increased markedly in the early stage of the stimulation, yet convulsion did not occur. Taurine contents in the cerebral cortex and brain stem returned to the resting level with 30 min after the onset of convulsions, while levels in the cerebellum remained high for 3 hr. Concentration of taurine in the plasma also increased with the onset of convulsions. On the other hand, taurine administration increased the threshold of convulsion by the stimulation in E1 mice.

Animals↗
PubMed1978

Small bowel melaena: 2 cases diagnosed by angiography.

Two cases of small bowel tumour presenting with melaena are reported. Selective visceral arteriography was found to be invaluable in the management of these cases. The first case presented with intermittent bleeding causing anaemia. Conventional barium studies of the small and large bowel revealed no abnormality. Superior mesenteric angiography revealed a mass lesion in the jejunum, with features characteristic of a leiomyoma. The second case presented with massive gastrointestinal bleeding. Selective visceral angiography was performed initially and revealed a large, mainly avascular, mass lesion in the ileum. Pathological examination showed a leiomyoma which had undergone cystic degeneration. The value of selective angiography in patients with suspected small bowel bleeding is discussed..

Adult↗