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E Kuhn

Publications and source records attributed to E Kuhn.

At least 37 records · Page 2Linked to original sources
PubMed1990

Renal cell carcinoma: value of imaging examinations in diagnosis and staging.

Authors analyse the value of intravenous pyelography, ultrasonography, computed tomography, angiography and fine needle aspiration biopsy in the detection, differentiation and staging of renal space-occupying lesions, on the basis of examinations performed in 158 patients, in comparison with results of surgery and/or clinical follow up. Their conclusion is that ultrasonography plays a major role in the detection and differentiation of these lesions, intravenous pyelography is only a complementary method, while computed tomography can provide diagnosis in cases with uncertain ultrasonographic findings. Staging has to be based on computed tomography. The role of angiography and fine needle aspiration biopsy is limited they need to be performed in a few selected cases only.

Adult↗
PubMed1990

[Dystrophia myotonica (Steinert disease)--a frequently misdiagnosed disease].

Dystrophia myotonica (Steinert's disease) is the most common hereditary disease of the neuromuscular system in adults. Its mode of inheritance is autosomal dominant. The gene responsible for its is located on chromosome 19 in the linkage domain of the loci for the apolipoproteins C2, C1 und E and of the creatine kinase of skeletal muscle (CKMM). Myotonic dystrophy is categorized in an adult and in a congenital form. In the adult form, the characteristic findings are muscular atrophy in certain regions of the body (face, neck and distally in the extremities) and myotonia. Cataract, intraocular hypotension, gonadal atrophy, conduction abnormalities in the heart and hearing deficiencies appear quite often in the course of the disease. In the congenital form, general muscle weekness (particularly pronounced in the face) is the leading finding, combined with retarded loco motor and mental development. A decisive criterion for the diagnosis of this form is the occurrence of myotonic dystrophy in the patient's mother. Electromyographic investigation is indicated when a suspicion of myotonic dystrophy cannot be ascertained on the basis of clinical and genetic findings. Myotonic runs in the EMG will then corroborate the suspicion. Recent electrophysiological investigations have indicated that at least three different types of channels for the passage of ions through the membrane of the skeletal muscle cells show abnormal behaviour, i.e. the channel for Cl-, Na+ and K+. These findings corroborate the hypothesis that the abnormality responsible for myotonic dystrophy is situated in the membrane systems. A pharmacological treatment of the muscular dystrophy has not yet been developed.(ABSTRACT TRUNCATED AT 250 WORDS)

Chromosomes, Human, Pair 19↗
PubMed1990

The association of waist hip ratio and angiographically determined coronary artery disease.

Body fat distribution as measured by the ratio of waist circumference to hip circumference (WHR) is now accepted as an important risk factor for a number of diseases. This study evaluated the association of WHR and coronary artery disease (CAD). Measurements included the subjects' height, weight, waist girth, hip girth, significant CAD on coronary angiography, and cholesterol levels. A history of myocardial infarction, angina, diabetes or hypertension was obtained from subject interviews. The subjects were analyzed in two age groups: younger than age 60 (88 men and 39 women) and age 60 or older (85 men and 63 women). For older women the relative odds of CAD comparing women at the 75th percentile of WHR to women at the 25th percentile was 3.67 (P = 0.003), with a 95 percent confidence interval of 1.57-8.57. The relative odds was reduced to 2.80 after adjusting for all other risk factors. WHR was significantly associated with angiographic evidence of CAD in all women combined after adjusting for age (P = 0.0004), but it was not significantly associated with CAD in younger women or in men. The results suggest that in older women the risk of CAD increases with a greater percentage of body fat in the abdomen.

Adipose Tissue↗
PubMed1988

The effect of pirenzepine on the functions of human platelets.

Despite the very high chemical similarity of pirenzepine (P) to the selected tricyclic antidepressive drugs (TCAD) (imipramine, desimipramine, nortriptyline and amitriptyline), P has a distinctly different effect on platelets, in particular, on serotonin uptake and platelet aggregation. Using two groups of nine healthy volunteers, mean age 27.7 and 27.5 years, respectively, assessment of the two indicators in vitro helped us to eliminate the possibility of a drug induced defect of the two thrombocyte functions, i.e. their aggregation and serotonin uptake. There is therefore, no reason to fear the danger of decreased hemocoagulation in ulcer patients treated with P for gastrointestinal hemorrhage. The results obtained in vivo using two tests which showed the level of platelet activation associated with release of a specific platelet protein (beta-thromboglobulin in platelet-poor plasma) and malondialdehyde in thrombocyte-rich plasma ruled out any changes, specifically their increase, and have disproved any kind of stimulating activity of P on thrombocyte reactivity.

Adult↗
PubMed1987

Muscular infiltration of the limbs in Hodgkin's disease. Report of three cases.

Three cases of muscular infiltration by Hodgkin's disease appearing on the limbs are reported. Diagnosis was based on various imaging methods (angiography, computed tomography and ultrasonography) followed by histologic verification in two cases. The pathomechanism of muscular manifestation remains unclear, haematogenous dissemination as well as progression from lymph nodes via lymphatics may be considered. Clinical symptoms were misleading in two cases. Radiotherapy was found effective in management of muscular infiltration.

Adult↗
PubMed1987

The metabolic effects of acute and chronic administration of gastrozepin.

The structure of gastrozepin (G) resembles that of tricyclic antidepressants and antihistaminic and antiserotonic cyproheptadine which are compounds with known metabolic effects. The object of this study was to test the potential action of G on the metabolism of basic nutrients, insulin and selected hormonal parameters after parenteral administration (10 and 20 mg G) and after chronic oral administration (50 mg G) during antiulcer therapy. Investigations carried out in two groups of 7 and 9 healthy volunteers, respectively, and on one group of seven patients with ulcer disease, revealed no changes in any of the blood parameters studied, nor in the excretion of catecholamines or 17-OH steroids in the urine. Our observations practically rule out any metabotropic activity of G, thereby differentiating it from tricyclic antidepressants and cyproheptadine. Isolated significant differences from the basal value seen after G and saline, can be attributed to other than pharmacological or specific mechanisms such as stress associated with the first examination, effect of fasting, individual response of the subjects, and so on.

Administration, Oral↗
PubMed1986

Plasma beta-endorphin immunoreactivity (PL-beta-ED-ir) in patients with ulcer disease and its management by acute and chronic administration of gastrozepin.

The initial level of PL-beta-ED-ir was significantly lowered in a group of 14 patients with gastroduodenal ulcer disease as compared with healthy volunteers (P less than 0.05). Immediately after i.m. administration of 20 mg gastrozepin (G) the PL-beta-ED-ir level increased but not significantly. Given orally over two weeks, G (50 mg/day) led to a more than doubling of the initial level (P less than 0.05). Controls showed no significant changes. A further meaningful change represented the time relationship of PL-beta-ED-ir during 5-hour observation to i.m. administration of 20 mg G before the start and after the end of the 2-week oral therapy. The placebo character of the above findings rules out the absence of any deviations of PL-beta-ED-ir in the diseased and healthy group after i.m. injection of saline. The study deals with the findings in relation to the pathophysiology of ulcer disease, and with a potential interference of G in the interrelation of the cholinergic and endogenous opiate systems.

Administration, Oral↗
PubMed1986

Nasopharyngeal lymphoid hyperplasia following treatment of patients with Hodgkin's disease.

Nasopharyngeal tomography was performed in 64 patients following treatment of Hodgkin's disease. Symmetric soft tissue mass involving roof and lateral walls of the nasopharynx was revealed in 33 cases, of which 24 underwent biopsies from the nasopharynx. Histology of biopsy specimens detected characteristic lymphoid hyperplasia. Its frequency was found to be influenced by the mode of previous treatment. Its occurrence was more frequent amongst those having received total nodal irradiation (TNI) as to those with extended fields irradiation (EFI), the difference proved to be statistically significant. This finding supports our hypothesis that nasopharyngeal lymphoid hyperplasia is a compensatory mechanism evoked by damage of lymphoid tissue due to previous therapy. Nasopharyngeal biopsy or a close follow-up is proposed, depending on the shape of nasopharyngeal mass and the condition of cervical lymph node area.

Hodgkin Disease↗
PubMed1985

[The immune status of patients with irradiated testicular neoplasms].

The authors present the results of investigations of the immune reactivity of 72 patients irradiated for testicle tumors. The responses to tuberculin and DNCB (2.4-dinitrochlorobenzol) were examined before the treatment, within twelve months after radiotherapy and three years after radiotherapy and when metastases appeared. After radiotherapy, the number of positive responses was slightly decreased in both examination methods, but the difference was in no case significant. Patients with metastases showed a significantly decreased response to DNCB compared to the results obtained before radiotherapy. 5.6% of the patients had suffered from herpes zoster. The incidence of other infective diseases was not increased. The conclusion is drawn that the moderate immunosuppression caused by radiotherapy does not exert any influence on the further way of living of patients with testicle tumors.

Adult↗
PubMed1984

Clinical value of immunohistochemistry with AF-antibody in the diagnosis of familial amyloid neuropathy.

Peripheral polyneuropathy associated with recurrent diarrhoea and orthostatic hypotension was observed in two unrelated German kinships and two sporadic cases. Congo red staining and polarization microscopy of biopsy specimens revealed amyloid deposits. Immunohistochemical investigation using the indirect immunoperoxidase staining with antisera to several purified amyloid fibril proteins showed a positive reaction with an antiserum to the prealbumin-related AF-amyloid in the families and one of the sporadic cases and with an antiserum to the immunoglobulin light chain amyloid (A lambda) in the other sporadic case. Therefore, the amyloid of the families and one of the sporadic cases was identified as the prealbumin-related AF amyloid, while the amyloid of the other sporadic case was of immunoglobulin origin. It is concluded that immunohistochemistry with antisera to the different amyloid proteins is useful in the differential diagnosis of amyloid neuropathy.

Adult↗