Search PubMed⌕ Search

Biomedical subjects

E Krause

Publications and source records attributed to E Krause.

At least 145 records · Page 8Linked to original sources
PubMed1979

[Transitory increase of the thyroid stimulating hormone in the newborn after polyvinylpyrrolidon-iodine application during parturition (author's transl)].

A vaginal Polyvinylpyrrolidon-iodine application was carried out in 120 patients as a prophylaxis against infection. In nine infants there was an increase in the thyroid stimulating hormone, which disappeared after a few days. The possibility of a decrease in the conversion of 1-thyroxine to 1-triiodothyronine when there is an increase of r-triiodothyronine which cannot block the thyroid stimulating hormone sufficiently is discussed.

Bacterial Infections↗
PubMed1978

Surgical management of massive pulmonary embolism.

Between 1972 and 1976, 24 patients have been treated by open pulmonary embolectomy with the aid of cardiopulmonary bypass (CPB). In 17 (71 percent) acute pulmonary embolism occurred 3 to 60 days after a surgical procedure. The remaining seven (29 percent) patients had chronic medical diseases. The interval between clinical manifestation of acute pulmonary embolism and the performance of open embolectomy ranged from 8 to 36 hours. The definitive diagnosis in all patients was made by pulmonary arteriography. Candidates for pulmonary embolectomy were selected by assessment of hemodynamic stuides: shock, arterial Po2 less than 65 mm. Hg, acidosis, pulmonary artery pressure higher than 20 to 30 mm. Hg, and central venous pressure elevated (patients in Class III or IV according to the Greenfield classification). The definitive indication for embolectomy was occlusion of the main pulmonary artery of more than 50 percent as well as occlusion of the right or left pulmonary artery. Of the seven patients operated upon between 1973 and 1974, three (43 percent) died in the early postoperative period. Between 1975 and 1976 the operative mortality rate in 17 patients was 23 percent (four patients). Our results show that prompt diagnosis of acute massive pulmonary embolism and better selection of patients may improve significantly the survival rate after open pulmonary embolectomy with CPB.

Adult↗
PubMed1977

Fetal development in experimental uremia.

Uremic women on hemodialysis with metabolic bone disease (hyperparathyroidism, osteomalacia resulting from defective vitamin D metabolism) and anemia (erythropoietin deficiency) are known to give birth to infants without bone disease or anemia. Therefore, skeletal development (enchondral and desmal bone formation) and hepatic erythropoiesis were evaluated in fetuses of uremic rats. These fetuses failed to show defective mineralisation or evidence of bone disease. Bolus injection of high doses of exogenous PTH into the maternal or fetal organism did not affect fetal bone histology. In addition, no apparent defect of bone mineralisation or bone formation was found in fetuses of ricketic rats. Normal mineralisation in the offspring of uremic rats may be explained by fetal hyperphosphatemia and/or insensitivity of fetal (woven) bone mineralisation to vitamin D. Absence of fetal anemia (normal hematocrits, normal density of hematopoietic cells in the liver) in the presence of maternal anemia is presumably due to the insensitivity of fetal erythropoiesis to erythropoietin.

Animals↗
PubMed1977

[Prevention using cephalothin in open-heart surgery].

To assay the efficiency of cephalothin prophylaxis in open-heart surgery, bacteriological examination of pressure-measurement units, intravenous catheter tips, and urine were made in 211 consecutive patients as well as blood cultures and sputum in suspected postoperative sepsis. Furthermore, cephalothin concentration in serum and tissue was determined in 12 consecutive adults with intact kidney function. Samples were taken before, during, and after the cardiopulmonary bypass, the tissue from the right atrium only before and after cardiopulmonary bypass. A high serum cephalothin level (80.04 +/- 23.35 microgram/ml) was measured 30 min after administration of 2 g cephalothin given as a 15-min-long i.v. infusion on induction of anesthesia. An antibiotic regimen - 4 X 2 g dose of cephalothin daily (first dose on induction of anesthesia) - provides a serum cephalothin level which is significantly higher than the cephalothin minimum inhibitory concentrations for most gram-positive organisms (0.475 microgram/ml) and so ensures an adequate antibiotic coverage throughout the surgical procedure and during the early postoperative phase of open-heart surgery.

Adult↗
PubMed1975

[Surgical treatment of cerebrovascular insufficiency due to extracranial obstruction of the carotid artery(author's transl)].

Reconstruction of the carotid artery was performed in 41 patients (between 1967 and 1974). All had had signs of cerebrovascular insufficiency. There was angiographic evidence of obliterating arteriosclerotic lesions in the carotid artery of 32 patients, carotid aneurysm in two, kinking of the internal carotid artery in four, and acute thromboses of the carotid artery in three. Early and late results indicate that best chances of success exist for stage II and III a cases. The high mortality rate in stages III b and IV (five of twelve patients) clearly shows that in these reconstruction of the carotid artery should be embarked on with caution, especially in the early stages.

Adult↗