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Biomedical subjects

E Kobayashi

Publications and source records attributed to E Kobayashi.

At least 433 records · Page 24Linked to original sources
PubMed1981

Elevated urinary excretion of metallothionein due to environmental cadmium exposure.

Metallothionein, a low molecular weight cadmium-binding protein, has been determined for the first time in urine of "itai-itai" disease patients and other Japanese women environmentally exposed to cadmium. On a group basis, the urinary metallothionein levels of "itai-itai" disease patients and suspected patients were significantly higher than that of women living in a cadmium-polluted area. Women living in a non-polluted area excreted significantly less metallothionein than women living in a cadmium-polluted area. A similar trend was observed for urinary beta 2-microglobulin, a nonspecific index of renal tubular dysfunction. However, mean levels of urinary cadmium in the "itai-itai" disease patients, suspected patients and women living in the cadmium-polluted area were similar. It is suggested that if, in addition to beta 2-microglobulin and cadmium, metallothionein is used as another index of cadmium exposure, monitoring of renal tubular dysfunction caused by cadmium may be more effectively carried out.

Aged↗
PubMed1981

[Studies on the biological effects of low level lead exposures. Part 1. Estimation of usefulness of some biochemical tests as parameters for occupational lead exposures (author's transl)].

Male painters of ceramic works were examined for parameters of biochemical lead poisoning such as erythrocyte ALAD, free erythrocyte protoporphyrin (FEP), and coproporphyrin (CP) in urine as well as parameters of lead absorption such as lead concentration in blood and urine (PbB & PbU) in order to estimate the usefulness of those biochemical tests for occupational lead exposures. Under the lead exposure level of these painters (PbB 5-50 microgram/l), log ALAD and log FEP showed good linear correlations with PbB, while ALAU and CPU showed significant but lesser correlations with it. The log ALAD showed a good linear correlation with log PbU, log FEP, and ALAU fairly good ones, CPU a significant but lesser correlation with it. ALAD and FEP were equally the most sensitive tests for increasing PbB or PbU. ALAU was the next most sensitive test and CPU was the least sensitive. From the view point of sensitiveness and obvious meaning as a test for lead poisoning, FEP is the most desirable test for occupational lead exposures.

Adolescent↗
PubMed1981

[Studies on the biological effects of low level lead exposures. Part 2. Biochemical responses and subjective symptoms in female lead workers (author's transl)].

Females painters of ceramic works were examined for parameters of biochemical lead poisoning such as erythrocyte ALAD, free erythrocyte protoporphyrin (FEP), ALA and coproporphyrin (CP) in the urine as well as parameters of lead absorption such as lead concentration in the blood and urine (PbB and PbU). Results were compared with those of male painters. At the same time, subjective symptoms were questioned in both male and female painters. Under the lead exposure levels of these painters (PbB 5-50 microgram/dl, PbU 10-200 microgram/l), FEP alone, among the four biochemical tests for lead poisoning, showed a different behaviour between the male and female painters. Among female painters, significant higher incidence of the symptom of "tiredness" was recognized when the PbB level became more than 20 microgram/dl and significant higher incidence of the "history of abortion" was seen as the PbU level became more than 60 microgram/l. However, any relationship between subjective symptoms and PbB or PbU level was not recognized among male painters. These results suggest that female painters are more susceptible to lead exposure than male painters.

Adult↗
PubMed1979

Small ventricles detected by CT-scanning in epileptic patients.

Relatively young 119 cases of generalized epilepsy and 99 controls of an identical age were selected. The bicaudate CVI was measured and the results were as follows: 1) In our cases, the mean of bicaudate CVI showed a smaller value than those of Hahn's in both epilepsy and control groups. 2) When the value of bicaudate CVI was set up below the point of 8.5 as "excessively small ventricle," the incidence rate of "excessively small ventricle" was 9% in the control group and 31% in the epilepsy group. The data showed higher incidences of small ventricles in the epilepsy group, and that the younger females have a tendency to have higher incidences of small ventricles. 3) To make clear the reason for the higher incidences of small ventricles in epilepsy, the small ventricle group and the non-small ventricle group in epilepsy were compared with each other from the points of the clinical course, EEG findings and frequency of attacks. No correlation or difference between them was found. Further investigation will be needed to make clear the etiology of small ventricles in epilepsy. However, it could be said at the present stage that not so many atrophic changes were observed in the younger patients of generalized epilepsy.

Adolescent↗