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Biomedical subjects

E Klaus

Publications and source records attributed to E Klaus.

At least 55 records · Page 3Linked to original sources
PubMed1978

Binding of benzo(a)pyrene metabolites to cellular DNA in perfused rat lungs.

The influence of pretreatment with monooxygenase inducers on total irreversible binding of metabolically activated [3H]-benzo(a)pyrene to cellular DNA and the formation of benzo(a)pyrene metabolite-deoxyribonucleoside adducts after cytochrome P-448 induction was studied in perfused rat lungs. Pretreatment with the cytochrome P-448 inducer beta-naphthoflavone increasing binding by a factor of 23. In lungs of induced animals, 0.45 pmoles of benzo(a)pyrene equivalents were bound per mg DNA. Binding to RNA and to protein was also considerably induced by beta-naphthoflavone. Phenobarbital treatment did not significantly increase binding to cellular macromolecules of rat lung. Analysis of hydrolyzed DNA of lungs from beta-naphthoflavone-treated rats by Sephadex LH 20 chromatography revealed the formation of at least two nucleoside adducts with metabolically activated benzo(a)pyrene one of which is probably due to modification of the DNA with a benzo(a)pyrene-7, 8-dihydrodiol-9, 10-epoxide and the other to modification of DNA with secondary metabolites of benzo(a)pyrene phenols.

Animals↗
PubMed1978

[A new topographic method for localising the venous angle of the deep cerebral veins on the lateral phlebographic phase (author's transl)].

A simple topographic method has been developed for the localisation of the venous angle on the lateral cerebral phlebogram. The principle depends on an angular measurement and an estimation of proportions which are statistically independant of each other. The method was tested on 103 phlebograms of adult patients with supratentorial spaceoccupying lesions. It was compared with conventional measurements; a number of advantages were found for using our method and its accuracy is as good as the other, most precise, methods.

Adenoma↗
PubMed1978

[Von Recklinghausen's neurofibromatosis with intracranial stenosis of the internal carotid artery and orbito-sphenoidal bone dysplasia (author's transl)].

A patient with fibromatosis of the skull and a so-called "parophthalmicus syndrome" is described in whom there was hypoplasia and stenosis of the homolateral internal carotid artery and aplasia of the ophthalmic artery. The vascular changes in this phakomatosis are discussed. We suggest that the vascular changes in the carotid be included in the extended parophthalmicus syndrome.

Carotid Artery Diseases↗
PubMed1977

A new topometric method of determining the position of the venous angle on cerebral phlebograms.

The authors devised their own craniometric method of determining the normal position of the venous angle on the lateral phlebogram. The fundamental principles of the method are as follows: (1) two auxiliary lines; i.e. (a) a horizontal line the nasion - the tuberculum sellae (N-TS); (b)a diagonal line the nasion - the tabula interna (N-Ti); (2) the two auxiliary lines form the angle alpha, which is equal to 20.44+/- 4.2 degree; (3) the proportional position of the venous angle (the point of intersection S on the diagonal N-Ti) is the ratio of the distance N-S to the total length of the diagonal N-Ti,i.e.: (formula: see text). The value is equal to 49.8 +/- 4.6%. The present method takes into consideration both the length and the height of the skull, has a small statistical dispersion and is simpler than the other available methods.

Brain↗
PubMed1977

[Quantitative analysis of particulate matter in infusion solutions, administration sets and additives (author's transl)].

There have been recevitly many comments on clinical and experimental reports which have demonstrated the safety problems associated with parenteral drugs contaminated with particles. Some countries have developed recommendations with a standard for counting of particles and their limits. Based on these limits, we have made a critical quantitative analysis of particulate matter in the most common commercially produced solutions, of particles added during manipulations in clinics and addition of drugs. Most authorities agree that particulate contamination should be kept to a minimum, above all in an intensive-care-unit where patients receive large quantities of solutions. As the risk to the patient is unacceptably high, many authors ask for filters to prevent the injection of particles in the bloodstream and their pathological consequences. A filter pore-size of 5 to 10 micron should be able to reduce this problem in a sufficient manner, without decreasing the infusion flow; whereas membrane-filters (0.22 micron), with their own problems, could also eliminate bacteria together with their microbiological hazards. Another source of particulate matter is represented by the injection of two or more drugs, administered at the same time, which may lead to chemical incompatibilities. This problem is not yet defined very well. To complete our quantitative analysis, we decided to start a prospective clinical study.

Critical Care↗