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Biomedical subjects

E Keller

Publications and source records attributed to E Keller.

At least 289 records · Page 16Linked to original sources
PubMed1986

Growth in thyrotoxicosis.

To study the effect of thyrotoxicosis on growth, 46 children and adolescents presenting with thyrotoxicosis have been reviewed and followed up for several years, in most cases until adult height was achieved. At presentation the children were underweight for height but were above expected heights even if already well advanced in puberty. Despite bone ages often being very advanced at diagnosis, the condition had no adverse effect on ultimate stature, which was commonly greater than that expected on the basis of parental height. Wight was rapidly regained on treatment, but nevertheless the younger subjects continued to be underweight despite adequate prolonged control of thyrotoxicosis.

Adolescent↗
PubMed1986

[Late results after meniscectomy].

Lesion of the meniscus is the most frequently occurring lesion in the region of the knee joint. Opinions are still divided as to the effects of partial, subtotal or total meniscectomy in provoking and/or promoting arthrosis. In this study, 70 patients with isolated injury of the meniscus were followed up on an average 11 years after meniscectomy. The subjective and clinical findings are juxtaposed with the x-ray findings. It was found that no arthrosis or no increase of the already preoperatively existing degree of arthrosis was seen in only 21.4% of the patients. Correlations are set up between instability resulting from meniscectomy on the one hand, and degree of arthrosis on the other.

Adolescent↗
PubMed1986

Cimetidine kinetics in renal transplant recipients.

Single dose kinetics of cimetidine (Ci) were investigated in 10 patients with renal impairment of varying degrees after renal transplantation. Thirteen healthy subjects and 7 patients with stable renal insufficiency served for control. The studied groups showed no difference in the non-renal Ci-clearance (Clnr) and the volume of distribution at steady state (Vdss). The renal Ci-clearance (Clr) declined parallel to renal function, whereas the estimation of renal tubular transport capacity (Clr/endogenous creatinine-clearance) was independent of renal function in either group studied. The healthy subjects and the control-patients showed a significant correlation between the reduction of the total Ci-clearance (ClB) and the endogenous creatinine-clearance (Clcrea) (ClB = 192 +/- 3.8 Clcrea, p less than 0.001). The individual ClB-values of the patients after kidney transplantation were found within the 90% confidence intervals of this regression line. According to these findings, dosage adjustments of Ci on the basis of Clcrea measurements appear to be valid for renal transplant recipients.

Adult↗
PubMed1986

[Thrombophlebitis of the right ovarian vein. X-ray computed tomographic diagnosis and monitoring of 2 cases].

We report two cases of post partum right ovarian vein thrombophlebitis: The aspect of the C.T. is presented, specifying the anatomic relations of the right ovarian vein. The C.T. progression under treatment is illustrated in one case by the appearance of a vena cava thrombosis and in another by a return to normal. The possibility of other examinations is discussed. Correct knowledge of these C.T. findings should allow a diagnosis and a treatment without invasive procedures.

Adult↗
PubMed1985

Purification of arogenate dehydrogenase from Phenylobacterium immobile.

Phenylobacterium immobile, a bacterium which is able to degrade the herbicide chloridazon, utilizes for L-tyrosine synthesis arogenate as an obligatory intermediate which is converted in the final biosynthetic step by a dehydrogenase to tyrosine. This enzyme, the arogenate dehydrogenase, has been purified for the first time in a 5-step procedure to homogeneity as confirmed by electrophoresis. The Mr of the enzyme that consists of two identical subunits amounts to 69000 as established by gel electrophoresis after cross-linking the enzyme with dimethylsuberimidate. The Km values were 0.09 mM for arogenate and 0.02 mM for NAD+. The enzyme has a high specificity with respect to its substrate arogenate.

Electrophoresis, Polyacrylamide Gel↗
PubMed1985

Genetic differences between the salt-wasting, simple virilizing, and nonclassical types of congenital adrenal hyperplasia.

Human leukocyte antigen (HLA) alleles and plasma 17-hydroxyprogesterone levels after ACTH stimulation were studied in 134 German families of patients with the salt-wasting (SW), simple virilizing (SV), or nonclassical (NC) late-onset form of congenital adrenal hyperplasia (CAH). Unexpected hormonal evidence for CAH was found in 6 otherwise healthy members of the relatives' group, who, therefore, were considered to be NC cryptic cases. HLA typing revealed a genetic difference between the 2 classical disease forms; SW CAH was strongly associated with Bw47, whereas SV CAH was closely linked to B5(w51). It also confirmed the nearly complete connection of NC CAH with B14. These alleles, especially Bw47 and B14, are mostly components of normally rare haplotypes: A3,Bw47,DR7 and Aw33,B14,DR1, respectively. They do not occur in the families' disease-unaffected haplotypes. Thus, it may be that all or almost all individuals from the general population bearing 1 of them are in fact CAH heterozygotes. Moreover, it seems possible to predict the severity of an infant's disease from his genomic type. The HLA linkage data were consistent with those obtained from ACTH testing, which showed significantly higher 17-hydroxyprogesterone increases in the genetically defined heterozygous relatives of SW patients than in the respective members of SV families. Of the families, 2 were also informative for mapping of the CAH disease gene(s) within the HLA-B to Glo interval.

17-alpha-Hydroxyprogesterone↗
PubMed1985

Arogenate dehydrogenase from Streptomyces phaeochromogenes. Purification and properties.

Arogenate dehydrogenase, the terminal enzyme of tyrosine biosynthesis in Streptomyces phaeochromogenes, was purified to homogeneity by a five-step procedure. The enzyme is a dimer of Mr 57 600 as determined by dodecyl sulfate polyacrylamide gel electrophoresis after cross-linking of the monomers, or of 66 300 as found by gel permeation chromatography, and consists of two identical subunits of Mr 28 100. The pI of the enzyme is 4.45, and the Km values are 0.105mM for arogenate and 0.01 mM for NAD.

Ammonium Sulfate↗
PubMed1985

[Effect of hormonally-induced prolongation of pregnancy in rabbits on maternal and fetal serum lipids].

The alterations of the lipid metabolism produced by placental insufficiency were investigated in animal experiments. Pregnant rabbits received Chlormadinon-acetate by intramuscular injection. The pregnancy was prolongated for 4 days, and a placental insufficiency developed. The lipid metabolism of the mothers and the fetuses was investigated by determination of beta-lipoproteides, triglycerides, cholesterol and HDL- and LDL/VLDL-cholesterol. The most important result is an increase of the concentrations of triglycerides and cholesterol of the fetuses during prolongation of pregnancy. Of the different cholesterol fractions estimated the LDL/VLDL-cholesterol-ratio excellently reflects the changes of the lipid metabolism during prolonged pregnancy.

Animals↗
PubMed1985

[Palliative bile duct irradiation].

Carcinoma of the common hepatic bile duct or common bile duct were treated by interstitial irradiation with gold seeds using the percutaneous transhepatic drainage partly boosted by external irradiation. The interstitial dose of 50 Gy was given in two applications and 40 Gy by linac. Twice histological examination showed wide tumor destruction of local irradiation, but also much more tumor extension than seen before by diagnostic investigation. Mostly the therapy is only palliative because of the infiltration of liver and lymph nodes.

Aged↗
PubMed1985

[Hemangiopericytoma of the liver].

The haemangiopericytoma is a rare type of vascular tumour. The article reports on a case of unusual location in the liver.

Diagnosis, Differential↗
PubMed1984

Effect of cimetidine on the hepatic extraction of indocyanine green, the portal pressure and the systemic circulation in patients with cirrhosis of the liver.

The effect of cimetidine on hepatic and systemic haemodynamic parameters was studied in seven patients with portal hypertension due to alcohol-induced cirrhosis of the liver and in one patient with peliosis hepatis following oral contraceptive steroids. The intravenous administration of cimetidine (350 mg as bolus, followed by 2 mg/min over 60 min) reduced the hepatic extraction of continuously infused indocyanine green (ICG) by 27%; this was statistically significant (P less than 0.01). Since the ICG clearance, calculated independently of hepatic perfusion, was lowered by 19%, this effect seems to be mainly due to a reduced capacity of the liver to remove the dye from the blood, rather than due to changes in perfusion. Cimetidine did not influence the elevated portal pressure in the patients with cirrhosis, or the normal pressure in the patient with peliosis hepatis. No significant effect was observed on heart rate, mean arterial pressure, pulmonary artery pressure, pulmonary capillary pressure and cardiac output. These studies indicate that the reduction of the hepatic ICG extraction following cimetidine is more the result of an inhibited capacity of the liver to remove the dye than of changes in the hepatic perfusion or in the systemic circulation.

Adult↗