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Biomedical subjects

E Kaufman

Publications and source records attributed to E Kaufman.

At least 109 records · Page 6Linked to original sources
PubMed1977

Multiple family therapy: a new direction in the treatment of drug abusers.

Multiple family therapy is presented as an important treatment augmentation for drug abusers in a variety of settings. The total family is viewed as patient with the drug abuser a symptom bearer. Common family dynamics are described as well as the techniques to create structural changes in families.

Ambulatory Care↗
PubMed1976

The abuse of multiple drugs. I. Definition, classification, and extent of problem.

Drug abusers have historically tended to abuse more than one drug. However, over the past 5 years there has been an increasing tendency to combine narcotics, alcohol, sedatives, and/or stimulants. The statistical increase of such abuse in the United States is documented by national surveys and the findings of drug treatment programs and detoxification centers. To clarify the confusion about such terms as "polydrug abuse" and "multidrug abuse," these terms are defined. A classification of multiple drug abuse is presented which demonstrates recent increases in each of four categories.

Alcoholism↗
PubMed1976

The abuse of multiple drugs. II. Psychological hypotheses, treatment considerations.

Several basic psychological hypotheses about multiple drug abuse are examined, i.e., social determinants, the effect of availability on extent of abuse, that drug abuse is a symptom rather than a disease, the relationship of social class to psychopathology, the lack of specificity of psychodynamics or psychopathology to drug choice, and the use of drugs to facilitate or obliterate concern with assertion, relieve neurosis, or provide homeostasis. There is a need for a variety of comprehensive, directive treatment approaches from which an individual treatment plan can be chosen. Such plans must consider which of the complex factors that can lead to multiple drug abuse are most prominent and can be remedied in each case.

Humans↗
PubMed1976

Endothelial damage from intraocular lens insertion.

Previous studies have shown that approximately 40 per cent of the corneal endothelial cells can be lost at the time of intraocular lens insertion. Momentary contact between the methacrylate surface and the endothelial cells causes an adhesion between these surfaces and results in extensive cell damage upon separation of the surfaces. This type of damage appears to be due to a biophysical interaction between these surfaces and may be avoidable by altering the surface of the lens.

Animals↗
PubMedDate not supplied

Phase I/II study of tandem cycles of high-dose chemotherapy followed by autologous hematopoietic stem cell support in women with advanced ovarian cancer.

The objectives of this study were to investigate the tolerability of a novel high-dose chemotherapy (HDC) regimen with peripheral blood progenitor cell (PBPC) support in patients with pretreated advanced ovarian cancer and to determine the maximum-tolerated dose (MTD) of topotecan in this setting. Advanced ovarian cancer patients previously treated with platinum-based first-line therapy were enrolled. After PBPC mobilization and harvesting, patients received three consecutive cycles of HDC with PBPC support. Cycle 1 was carboplatin area under the concentration curve 20 and paclitaxel 250 mg/m(2). Cycle 2 was topotecan starting at 5 mg/m(2), dose escalated in 2 mg/m(2) increments, and etoposide 600 mg/m(2). Cycle 3 was thiotepa 500 mg/m(2). After each cycle, PBPCs were infused. Granulocyte colony stimulating factor (5 microg/kg/day) was administered until neutrophil recovery occurred. Seventeen patients were enrolled; all were safety evaluable. The most common nonhematologic toxicity was grade 3 mucositis (44%). Engraftment of PBPCs was successful in all patients after each cycle, and no treatment-related deaths occurred. Of 14 patients with measurable disease, 5 (36%) had complete responses, 2 (14%) had partial responses, and 4 (29%) had stable disease. The median progression-free and overall survivals were 7 and 18 months, respectively. The MTD of topotecan was not reached. The tolerability and activity of this regimen in patients with advanced ovarian cancer warrant further investigation.

Adult↗
PubMedDate not supplied

Family system variables in alcoholism.

The social system of the family is a major variable in the syndrome of alcoholism. The family system may generate or promote the development of alcoholism in a family member. The alcoholic behavior of a family member may disrupt and impair family system function. Although these relationships highlight important correlations between alcoholism and family function, research evidence demonstrates that the relationship is complex. Simple models of a typical alcoholic family no longer suffice. Research on four aspects of family alcoholism are reviewed: family reactivity patterns, ethnic family styles, gender of the alcoholic spouse, and stages of alcoholism. These data support the conclusion that family systems are an important variable in the genesis, consequences, and treatment of alcoholism.

Alcoholism↗