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Biomedical subjects

E Kaiser

Publications and source records attributed to E Kaiser.

At least 127 records · Page 7Linked to original sources
PubMed1981

Cytophotometric evidence of non-S-phase extra-DNA in human neuronal nuclei.

After Feulgen staining with acriflavine-Schiff, the DNa content of glial and neuronal nuclei from various sites of the human CNS (pre- and post-central gyrus, cerebellar cortex and spinal cord) were determined by fluorescence cytophotometry. The specimens were obtained from twelve adult human autopsy cases. Glial cell nuclei always revealed a biomodal DNA distribution pattern with a large 2c and a smaller 4c peak. The 4c peak was most prominent in the cerebellum. A few 8c glial nuclei were found. Neuronal cell nuclei disclosed DNA histograms with hyperdiploid means in the range 2.2-2.5c (1.8-2.9c for the individual populations). Tetraploid 4c DNA values were not observed, neither in Purkinje cells, nor in pyramidal cells. In eleven out of a total of forty-four slides the higher DNA means of neuronal nuclei were found to be statistically significant (P greater than 0.05) when compared with a population of 2c hepatocytes on the same slide. The results indicate the existence of some 'extra DNA' in human neuronal cell nuclei, the biological significance of which has still to be elucidated. It is however, suggested that it may play an important role in the functional activity of the CNS.

Adult↗
PubMed1981

[Changes in interferon and thymus factor levels as well as in lymphocyte populations in patients with mammary carcinoma (author's transl)].

Changes in interferon and thymus factor as well as in cAMP levels and lymphocyte populations were recorded from patients with mammary carcinoma. They were equally recordable from those in whom no clinical tumour had been detectable at the time of postsurgical examinations as well as from patients with metastases distant from the primary tumour. The possibility for centralised disorder of immunological tumour cell defence in carcinoma patients is discussed.

Adenocarcinoma, Scirrhous↗
PubMed1980

[Antiandrogen therapy of acne, falling hair and hirsutism (author's transl)].

Hormonal influences give rise to hirsutism and may encourage the appearance of seborrhea, acne and falling hair. Androgenically active processes in the cells of the end organs (e. g. sebaceous glands, hair roots) and in the endocrine regulation center may also be responsible for androgenic manifestations in women such as excretion of androgens by suprarenals and ovaries as well as its metabolization and final elimination. The central inhibiting effects of large doses of estrogen or gestagen have been taken advantage of since the sixties with varying therapeutic success. Advances in the treatment were only brought by the development of antiandrogenic progestogens and finally the synthesis of the "antiandrogen" cyproterone acetate in particular which, when selectively applied with critical consideration of the clinical symptoms, brings about a satisfactory therapeutic result for the cosmetically sensitive woman.

Acne Vulgaris↗
PubMed1979

Pathomorphologic findings in short-tailed voles (Microtus agrestis) experimentally-infected with Frenkelia microti.

Following oral infection of Microtus agrestis with sporocysts of Frenkelia microti, transient focal necrosis and cellular infiltrations in the liver, hyperplasia of lymphoid organs, and inflammatory infiltrations in the heart, pulmonary veins, skeletal muscles and brain occurred during the first asexual multiplication period of the parasite in the liver. Frenkelia cysts were first observed in the brain 23 days after infection.

Animals↗
PubMed1978

[Life cycle of Frenkelia. IV. Pathomorphological findings in the organs of experimentally infected bank voles].

In 1975 the buzzard (Buteo buteo) was found to be the final host of Frenkelia clethrionomyobuteonis. After this discovery it became possible to investigate systematically the pathomorphology of the infection in the intermediate host, the bank vole (Clethrionomys glareolus). Fifty bank voles were infected orally with a suspension of sporocysts recovered from the faeces of experimentally infected buzzards. Each rodent receive 7000 sporocysts. Six controls each were given a faecal suspension from a non-infected buzzard. The voles were killed between 1 and 140 days after infection and examined histologically. Between the 5th and 8th day of the infection during the schizogonic multiplication of the parasite a focal necrosis of liver cells and of the liver parenchyma is observed followed by a reversible resorptive inflammation associated with siderophagia and the occurrence of giant cells. The spleen was spodogenously enlarged up to twice its normal size. There also was haemosiderosis of the bone marrow, the liver and the spleen up to 25 days after infection. At the same time the erythropoiesis in the bone morrow, the spleen and in the lymph nodes increased; there also was a lymphoid hyperplasia in spleen and lymph nodes. About 10 days after infection a reversible infiltration with lymphocytes and plasma cells developed in the liver, heart and brain. This infiltration was again detectable as perivascular and meningeal reactions in the brain after the 49th day after infection. The second asexual multiplication of the parasite was seen histologically in the grey and white matter of the central nervous system after the 18th day of infection. The developing cysts increased in size continuously thereby compressing the surrounding nervous tissue. Disseminated focal necrosis with resorptive inflammatory components was prominent in the parenchyma of the brain after the 49th day of infection. It was possible to differentiate between damage in single organs and systemic pathological lesions. The lesions in single organs were directly connected with the development of parasitic stages in the liver (schizonts) and in the brain (cysts). The generalized lesions occurred in the haemopoietic system after an impairment of the blood during the first asexual multiplication. They also occurred in the immunocytic systems after the first and during the second asexual multiplication and during the relatively late cystic phase of the parasite in the brain. The pathogenesis of the disintegration of blood cells is not clear. The immunocytic reaction can be considered an immunological response of the host against the parasite. The effect of the development of the cysts on the function and structure of the central nervous system is expected to lead to an increasing impairment of the motility of the intermediate host.

Animals↗
PubMed1977

[Effect of menstrual hygiene (tampons vs pads) and of the form of contraception on pH and bacterial infection of the vagina].

In menstrual hygiene vaginal tampons are preferred. Supposedly intravaginal application causes discharge. Healthy women using pads as well as tampons were examined before, during, and after menstruation. During two menstrual cycles vaginal pH was measured, bacteriological and mycological cultures were set up. The results indicated no changes of cervical-vaginal-secretion, nor was the pH changed. Taking the used contraceptive method into consideration, we found that intrauterine devices and oral contraceptives caused most of bacterial discharge and the expected shifting to alcaline pH. No increase of vaginal fungus was noted. The use of intravaginal tampons for menstrual bleeding therefore had no ill effects.

Adolescent↗