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Biomedical subjects

E Jacobi

Publications and source records attributed to E Jacobi.

At least 19 recordsLinked to original sources
PubMed1999

[Developing a rehabilitation databank for Germany--conceptional considerations exemplified by UDSMRSM (Uniform Datasystem of Medical Rehabilitation)].

Current research in medical rehabilitation lacks well designed clinical studies to demonstrate the efficacy, effectiveness and efficiency of rehabilitation interventions. Randomized controlled studies (RCTs) are difficult to conduct in rehabilitation research because of multiple variables and difficulties to include appropriate control groups. Therefore, we propose the development of a rehabilitation database and network for Germany to allow data collection from daily rehabilitation practice in the three areas medical-objective, perceptive-subjective and economical-social, designed after the example of the Uniform Datasystem of Medical Rehabilitation (UDSMRSM). This American database uses the Functional Independence Measure (FIM) to monitor functional changes in medical rehabilitation patients. Quarterly reports are sent out to participating institutions and allow comparisons with other regional, national and international institutions. The database demonstrates an initial step towards the concept of "evidence-based rehabilitation" by defining a common rehabilitation outcome and it allows benchmarking with other rehabilitation facilities. This permits the development of quality standards, cost analyses, payment systems and a new research methodology that can identify the most effective rehabilitation method through statistical analysis for focused clinical trials.

Activities of Daily Living↗
PubMed1999

[Databank-oriented physician generated medical record as the basis for outcome quality in rehabilitation medicine].

A new approach is presented for the medical reports in rehabilitation medicine. It is realized with the integration of formatted textblocks into a client-server based workflow. This technology is able to reduce hardware and costs. The data material, extracted from the daily routine of the hospital, is characterized by high quality and it supports statistics and quality management. It is a uniform database for rehabilitation medicine and for rehabilitation research. Since 1996 the medical report software has been established in all rehabilitation hospitals accredited by the LVA Württemberg pension insurance agency.

Databases, Factual↗
PubMed1998

Criteria for prosthetic provision: "he who pays the piper calls the tune".

Previously instituted policies regarding prosthetic limb provision had been deemed dependable. A follow-up home visit study showed that 18 of 60 patients that had been provided with prostheses, did not make use of them. Analysis showed that three categories of patients made up the large majority of the non-users; double amputees, blind persons and those with psychiatric disorders. In order to attempt to eliminate the wastage of prosthetic provision to non-ambulators a new policy decision was made. Doubtful ambulators and those from the three aforementioned categories will be initially provided with temporary prostheses. Only after a period of months of temporary prosthetic usage at home will a decision be made as to whether a permanent prosthesis will be issued.

Adult↗
PubMed1998

[Ulm Scientific Rehabilitation Research Group--"building blocks in rehabilitation"].

The Rehabilitation Research Network of Ulm on "Bausteine der Reha" consists of several departments of the University of Ulm, and various rehabilitation hospitals and cooperates with a pension insurance institute (LVA Wuerttemberg). The aim of this interdisciplinary approach is to evaluate process and outcome of rehabilitation measures considering specific clinical and rehabilitative questions with main emphasis on epidemiological and economic aspects. The Rehabilitation Research Nétwork of Ulm is subdivided into clinical projects and cross-sectional subjects. The clinical studies deal with cardiovascular and neurological rehabilitation and rehabilitation in disorders of the musculoskeletal system. The cross-sectional topics contain special fields such as biometry, health economics, epidemiology and occupational rehabilitation. All participating institutions have access to a central database with uniform structure of the data.

Forecasting↗
PubMed1990

[Assessment of the effectiveness of inpatient rehabilitation measures in patients with chronic low back pain: a prospective, randomized, controlled study].

Chronic low-back pain is a frequent symptom causing considerable socioeconomic costs in many countries. Outpatient treatment of low-back pain often remains unsatisfactory. In our prospective study, one hundred patients on the five months waiting list were allocated randomly to attending the hospital either four months or six months later, the latter serving as a control group for those undergoing treatment. Health status was assessed using a multidimensional questionnaire, which had proven a reliable, valid and sensitive instrument in former studies. After four to six weeks of multidisciplinary inpatient treatment, a significant decrease in pain, anxiety and depression was found, whereas no improvement was observed in the control group. Multidisciplinary inpatient treatment therefore at least has short-term positive effects on patients' health status.

Back Pain↗
PubMed1987

[Intervertebral disk surgery and postoperative rehabilitation treatment: effect on health status].

There is an increasing frequency of lumbar disc surgery in many countries. In the Federal Republic of Germany, many patients are admitted to in-patient rehabilitation immediately after surgery, which causes additional socioeconomic costs. In order to assess the efficiency of this therapy approach, we used the MOPO Scales, a thoroughly evaluated instrument describing patient health status in both its physical and psychosocial dimensions. In 79 patients who had been followed-up over six months post-discharge from in-patient rehabilitation, a significant increase in mobility, physical activity, activities of daily living, household activities, and social activities was found, as well as a significant decrease in pain, depression and anxiety. These results prove lumbar disc surgery combined with immediate post operative rehabilitation to be efficient.

Activities of Daily Living↗
PubMed1986

Assessing health status after inpatient rehabilitation in rheumatoid arthritis.

Evaluation of different therapy programmes, e.g. inpatient rehabilitation, in rheumatoid arthritis requires valid, reliable and sensitive instruments describing patient health status. Traditional measurements such as ESR, joint count or radiographic findings do not suffice for this purpose, particularly because they neglect the psychosocial dimensions of impairment. We report upon a questionnaire, MOPO scales, a German adaptation of the Arthritis Impact Measurement Scales. We found the questionnaire to be valid, reliable and sensitive to change. The main application of MOPO scales is in multidimensional measurement of patient health status and in detection and documentation of therapeutically induced change.

Activities of Daily Living↗
PubMed1981

Platelet adhesiveness: methodology for testing in humans.

Platelets play an important role in the pathogenesis of early thrombus formation and might even be involved in initiating the process of artherosclerosis. Various platelet adhesiveness test methods are discussed. Results of an in vitro test in about 600 patients with various diseases are given. The effect from anti-platelet drugs like dipyridamole and acetyl salicylic acid in preventing increase of platelet adhesiveness due to a biologic stressor are compared with those obtained with isoxsuprine. Platelets play an important role in the pathogenesis of early thrombus formation. Platelets might also be involved in initiating the process of atherosclerosis. Therefore, it is understandable that various test methods to measure platelet behavior has been developed.

Arterial Occlusive Diseases↗
PubMed1981

[Quantitative laser-nephelometric detection of rheumatoid factor, using IgG coated latex particles (author's transl)].

The laser-nephelometric test (Latex RF test) detects rheumatoid factor activity, and is based on immune complex formation between IgG coated latex particles and rheumatoid factor. This test requires little time and gives qualitative results in good precision. The latex nephelometric test and the frequently used agglutination tests (Waaler-Rose, Latex agglutination test) give the same qualitative results. In the quantitative assay higher nephelometric results correlate on average with higher titers in the Waaler-Rose and Latex agglutination test. The high standard deviation could be explained by the fact that other factors (IgG rheumatoid factor, IgG and IgG-IGM immune complexes), in addition to the IgM rheumatoid factor concentration, influence the immune complex formation in vitro.

Agglutination Tests↗
PubMed1979

[Diagnosis of systemic lupus erythematosus (author's transl)].

The positive demonstration of ds-DNA in a particular concentration is a diagnostic criterium for systemic lupus erythematosus. The most commonly used test at present has the disadvantage that radioactively marked substances are required. Thus a test method was developed for the laser nephelometer which is simple and which detects the antigen-antibody complex directly. First measurements on sera from SLE patients showed a good correlation with radioimmuno assay.

Antibodies, Antinuclear↗
PubMed1979

[Effects on platelet functions].

Platelet adhesiveness was measured in a total of 589 healthy volunteers and patients. Patients suffered from heart failure, diabetes mellitus, myocardial infarction and deep vein thrombosis have a significant higher platelet adhesiveness as healthy volunteers. The effect of the socalled stressors on platelet adhesiveness was shown in vivo; the same values of platelet adhesiveness were seen as in patients. Therefore it can be concluded that stressors constitute a risk factor in patients with altered vessel walls.

Arterial Occlusive Diseases↗
PubMed1978

Platelet kinetics in Crohn's disease.

The pathogenesis of thrombocytosis in Crohn's disease was analized in ten non-treated patients using the 51Cr labelling method. The data obtained were compared to those taken from a control group. Besides platelet survival time, platelet turnover, surface radioactivity, platelet adhesiveness and morphological aspects of bone marrow were investigated. Platelet survival time in patients with Crohn's disease proved to be significantly shortened (p less than 0.001), whereas platelet turnover appeared augmented. No additional radioactivity is encountered from the organs scanned. The relative platelet adhesiveness is diminished while thrombocytopoesis in bone marrow is augmented.

Blood Cell Count↗