Search PubMed⌕ Search

Biomedical subjects

E J Field

Publications and source records attributed to E J Field.

At least 127 records · Page 7Linked to original sources
PubMed1971

Specific lymphocyte sensitization in cancer: is there a common antigen in human malignant neoplasia?

From human cancer tissue a basic protein can be extracted by the method which yields encephalitogenic factor when applied to human brain. This tumour basic protein (obtained from several different neoplasms) acts as an antigen in the cytopherometric test for malignant neoplasia and in general gives higher results than does brain basic protein. The reverse is true when degenerative disease of the nervous system is studied. The basic protein extractable from brain and from tumours thus has some degree of specificity probably referable to its amino-acid sequence.

Adolescent↗
PubMed1971

Lymphocyte sensitization in sarcoidosis.

Nineteen patients with sarcoidosis have all been shown to have lymphocytes in their blood sensitized to several antigens, including purified protein derivative of tuberculin and Kveim agent, though they had negative or greatly reduced Mantoux reaction. Two patients who repeatedly failed to "convert" after B.C.G. inoculation showed the same cell sensitization phenomena. No explanation can be offered for this anomaly.

Adult↗
PubMed1971

Lymphocyte sensitization to nervous tissues and muscle in patients with the Guillain-Barré syndrome.

By means of an electrophoretic method lymphocytes from patients with the Guillain-Barré syndrome (`acute idiopathic polyneuritis') have been shown to be sensitized to both encephalitogenic factor (EF) and a similar basic protein prepared from human sciatic nerve (SNBP). Sensitization was more marked in the acute stage of the disorder during which there also appeared to be a degree of sensitization to muscle. The results are consistent with the view that lymphocytic infiltration of peripheral nerves in the condition is of pathogenetic significance.

Adult↗