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E Iversen

Publications and source records attributed to E Iversen.

52 records · Page 3Linked to original sources
PubMed1984

TRH immunoreactivity in the thyroid gland.

Methanol extracts of dog and pig thyroid tissue contained considerable amounts of thyrotropin releasing hormone immunoreactivity (iTRH): 2.98 +/- 1.38 and 1.83 +/- 0.58 pmol/g thyroid wet weight, respectively (mean +/- SD). This iTRH was not due to ether extractable materials and behaved like TRH standard in dilution experiments, during gel filtration on Sephadex G-25 and during thin layer chromatography on a silica gel plate. Cation exchange chromatography on SP-Sephadex C-25 revealed that the iTRH in methanol extract was heterogeneous. However, part of the iTRH applied on the column was eluted as synthetic TRH: 0.209 +/- 0.046 and 0.052 +/- 0.021 pmol/g dog and pig thyroid, respectively. During incubation with rat serum, the SP-Sephadex purified iTRH disappeared in parallel with TRH. These studies indicate that the thyroid contains small amounts of iTRH which behaves identically to synthetic TRH.

Animals↗
PubMed1979

Unconjugated thyroxine and triiodothyronine in urine: influence of age, sex, drugs and thyroid function.

The 24 h urinary excretion (dU) of T4 and T3, determined by radioimmunoassays using extraction and separation on Sephadex columns, is higher in men than in women (mean dU-T4 and dU-T3 +/- 2 SD: 2.6 +/- 0.9 vs. 2.2 +/- 1.0 and 2.5 +/- 1.0 vs. 2.0 +/- 0.8 nmol, respectively). The excretion of T3 decreases with age, but expressed relatively to dU-creatinine there is no effect of age and sex. Children have increased T4 and T3 to creatinine excretion ratios and neonates excrete predominantly T4. Oestrogens, acute salicylate loading and diurnal variation yielded results, which were at variance with the hypothesis that dU-T4 and dU-T3 mirror corresponding free hormone concentrations in serum, and there was only a weal positive correlation to total serum hormones in thyrotoxicosis as well. General clinical use of urine T4 and T3 is obviated by poor diagnostic discrimination and inherent analytical and interpretative disadvantages.

Adolescent↗
PubMed1971

Epidemiological basis of tuberculosis eradication. 11. Mortality among tuberculosis cases and the general population of Greenland.

Greenland experienced, during the 1950s, a decline in mortality such as is on record for hardly any other place in the world: from 24 per 1 000 in 1951 to 8 per 1 000 in 1960, a decline of more than 10% per year. Deaths from tuberculosis were especially reduced. Whereas more than one-third of all deaths in 1951 were considered to be due to this disease, practically no deaths are ascribed to it today.This rapid improvement in the health situation in Greenland, which coincides with a large-scale development programme, is documented in detail in the present paper. The study is based partly on official mortality statistics and partly on a 9-year follow-up study of mortality and of morbidity from tuberculosis in the total population of West Greenland registered in 1955. The existence of such data for a developing area is probably unique.

Adolescent↗
PubMed1967

Epidemiological basis of tuberculosis eradication. 7. Application of life-table methods for assessing the prognosis for tuberculosis patients.

The experience of a group of patients, observed in a follow-up study, may conveniently be described by means of decrement tables, of which the survival table is the best known. Just as this table shows how a population group has decreased gradually because of death, so other decrement tables may depict the cumulative effect of cure, or of death and cure combined.Decrement tables can be established not only when all patients under study have been observed from the onset of their disease until cure or death, but also when patients with varying durations of disease have been followed for only a few years; in this case the statistical technique used for the construction of life-tables must be applied.This paper demonstrates in detail the tabulations and calculations involved in this technique, using nationwide data from the Danish Tuberculosis Register as the basis, and applying the technique to aspects of the prognosis for tuberculosis patients that have hitherto been difficult to quantify.

Denmark↗
PubMed1967

Epidemiological basis of tuberculosis eradication. 8. Some factors of significance for the prognosis for a tuberculosis patient.

It is a general clinical experience that prognosis varies not only from one disease to another, but also between different categories of patients suffering from the same disease. The object of the study reported was to demonstrate quantitatively how the prognosis of respiratory tuberculosis depends upon the patient's age and sex and upon the severity of disease at the time of diagnosis. Based as it is upon a follow-up through the years 1961-64 of all respiratory tuberculosis patients in Denmark, the study also provides an epidemiological characterization of the course of the disease in northern Europe today.TWO ASPECTS OF PROGNOSIS ARE CONSIDERED: the patients' mortality and their curability. A convenient prognosis index for a group of patients, combining the two aspects, is obtained by expressing the number of patients dying before cure as a percentage of the initial size of the group. The comparison between various patient-categories in the study material is made partly by means of this index and partly by means of annual death and cure rates.

Adolescent↗
PubMedDate not supplied

Breast cancer following multiple chest fluoroscopies among tuberculosis patients. A case-control study in Denmark.

A case-control study of breast cancer among tuberculosis (TB) patients in Denmark (1937-1954) was conducted to provide additional information on the radiation risk associated with low-dose chest fluoroscopy exposures. Records of 46013 TB patients were linked to the Danish Cancer Registry and 125 subsequent female breast cancers identified. Medical records were located for 89 (71%) of these women who developed breast cancer and on 390 controls, who were individually matched to cases on age and calendar year of TB diagnosis, and survival. Common risk factors for breast cancer such as nulliparity (relative risk (RR) = 2.5) and high relative weight (RR = 2.6) were also identified in this population of TB patients. However no risk was evident with exposure to any type of fluoroscopy (RR = 0.6; 95% CI = 0.2-1.4), or to fluoroscopies performed to monitor lung collapse therapy (RR = 0.8; 95% CI = 0.5-1.4). Although based on only 7 breast cancers, there was a suggestion of an increased risk among women who received greater than 1 Gy to their breasts (RR = 1.6; 95% CI = 0.4-6.3). Because of the infrequent use of fluoroscopy in our study, the breast doses were too low, 0.27 Gy on average, to expect to detect a significant elevation in breast cancer risk overall. The findings do suggest, however, that current estimates of breast cancer risk following radiation are not greater than presently accepted, and that a relative excess of 40 per cent can be excluded with reasonable confidence following breast doses on the order of 0.3 Gy.

Breast Neoplasms↗