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Biomedical subjects

E Hansen

Publications and source records attributed to E Hansen.

At least 91 records · Page 5Linked to original sources

Chronometric analysis of apparent spotlight failure in endogenous visual orienting.

Subjects made speeded responses to peripheral luminance increments or decrements preceded by informative central precues. In 4 experiments one of these stimuli was much more likely to occur than the other. In a simple detection task, the likely and unlikely stimuli showed equivalent cuing effects. In a discrimination task (bright/dim), the likely stimuli showed cuing but the unlikely one did not (spotlight failure), and there was a tendency to make the likely response when the unlikely stimulus occurred at the cued location. In Experiment 5, the 2 stimuli were equally likely, and a choice was required. Large cuing effects were observed for both stimuli with no evidence of a speed-accuracy trade-off. A logogen-activation framework is described within which criterion and sensitivity adjustments are needed to accommodate the full pattern of results. Endogenous orienting appears to enhance processing of all stimuli at attended (relative to unattended) locations, an effect that may be masked by specific stimulus or response expectancies.

Adult↗

Pentoxifylline modulates meningeal inflammation in experimental bacterial meningitis.

Pentoxifylline has been shown to decrease endotoxin-induced tumor necrosis factor alpha production and reverse the inflammatory actions of interleukin-1 (IL-1) and tumor necrosis factor on leukocyte function. Because of the potential role of this cytokine-leukocyte interaction in the pathogenesis of bacterial meningitis, we investigated the ability of pentoxifylline to modulate meningeal inflammation in the rabbit meningitis model. Pentoxifylline treatment (initially an intravenous injection of 20 mg/kg followed by 6 mg/kg per h) started 20 min before intracisternal injection of 20 ng of Haemophilus influenzae type b lipooligosaccharide (endotoxin) reduced significantly concentrations in cerebrospinal fluid of leukocytes (P less than 0.0001), protein (P less than 0.001), and lactate (P less than 0.001) during the 9-h infusion compared with values in intravenous-saline-treated rabbits. When pentoxifylline was given 1 h after H. influenzae type b endotoxin, the mean peak lactate and leukocyte concentrations in cerebrospinal fluid were significantly lower than those in control animals. Pentoxifylline also significantly decreased lactate and protein concentrations (P less than 0.05) and tended to diminish leukocyte counts (P = 0.08) compared with results in control animals after antibiotic-induced release of endotoxin in animals with H. influenzae meningitis. In this regard, dexamethasone was superior to pentoxifylline and no synergism was observed when the drugs were combined. Additionally, pentoxifylline attenuated meningeal inflammatory changes induced by intracisternal inoculation of 10 ng of rabbit recombinant IL-1 beta compared with results in either dexamethasone- or saline-treated animals. We conclude that pentoxifylline is effective in this animal model in modulating the meningeal inflammatory response following intracisternal inoculation of H. influenzae type b endotoxin or organisms or rabbit recombinant IL-1beta.

Animals↗

Effects of the eyerobics visual skills training program on static balance performance of male and female subjects.

10 male and 10 female students in physical education aged 19 to 23 yr. were each randomly assigned to both the experimental and control groups. Experimental subjects were given the 4-wk. Eyerobics visual skills training to assess its effects on static balance performance as measured on a balance stabilometer. Analysis indicated that the women performed significantly better than the men over-all. Balance performance by the trained group improved significantly.

Adult↗

[Possibilities of objective assessment of the course of activation in ideomotor training].

An active exploration of movement tasks is accompanied with central nervous activation. Its systematical examination needs a teamwork of scientists of various branches of knowledge (i.e. physiology, psychology, sport sciences). Mental training (motor imagination - MI) was chosen as a model for such examinations. In connection with the execution of MI there are characteristic chances of the mean alpha frequency of the EEG, heart rate, respiration rate and skin conductance. The time course of these parameters depends on the number, the duration and the sequence of MI. A graduated submaximal load on ergometer has no influence on the course of the examined parameters. Our investigation allows the conclusion that different activation processes go on within different subsystems during the execution of MI. From a physiological point of view it seems to be necessary that a concrete paradigm of MI must be examined concerning the course of the parameters and, thus, to guarantee the effort of MI.

Adolescent↗

Cadmium exposure in Denmark. Based on analyses of liver and kidney tissues.

To determine the cadmium exposure level in the Danish population, tissue samples of kidney and liver were collected over the period 1981 to 1987 at the Institutes of Forensic Medicine in Copenhagen, Odense and Aarhus. A total of 795 samples were collected, of which 143 were selected for analysis using, the criteria sudden violent death (accident, homicide or suicide). Cadmium concentrations in kidney cortex increased by age to a maximum of approximately 22 micrograms/g/g (w/w) in the age group 45-55 years and decreased in the older age group, while liver concentrations tended to increase throughout the entire lifespan. Cadmium concentrations in kidney cortex and liver were found significantly correlated. The findings are in good agreement with internationally published data, but lower than previously reported Danish concentration levels. The reason for this difference is discussed.

Adolescent↗

Perinatal risk factors and first-year vocalizations: influence on preschool language and motor performance.

Spontaneous vocalizations of nine children with neonatal risk factors were systematically tape-recorded during the first year of life, as were those of 20 randomly chosen children without such risk factors. All the children were also given a battery of tests measuring language, speech, intelligence and motor function at six years. Cumulated tape-recordings for the periods six to 11 months and six to 14 months showed the infants with risk factors to have a significant reduction in various reduplicated syllables and consonants during the first year compared to those without risk factors. At six years, six of the nine at-risk children had an abnormal language test, as did two of the 20 without neonatal risk factors. Children with abnormal language tests performed significantly more poorly on various motor tasks; they also had had significantly fewer reduplications and consonants during infant vocalizations than the children with normal language tests. Perinatal risk factors may delay the production of prelinguistic sounds, and analysis of vocalizations might help to identify children who are at risk for later language disorders.

Apgar Score↗

A controlled release form of madopar in parkinsonian patients with advanced disease and marked fluctuations in motor performance.

Flucuations in motor performance is a major problem in long-term levodopa treatment of Parkinsonian patients. A slow release preparation of levodopa with benserazide, Madopar HBS, has been developed in an attempt to decrease this problem. Eleven of 22 Parkinsonian patients with advanced disease and marked fluctuations experienced long-lasting benefit with reduction of their fluctuations in motor performance on treatment with Madopar HBS; 11 dropped out within the first 5 months of the trial. This was probably due to lack of experience with the effect of this new slow-release formulation. Nine patients (82%) required an additional dose of standard Madopar, especially in the morning. Significant improvements were found for akinetic phenomenon and dystonic cramps, and with the global evaluation of motor fluctuations. The occurrence of peak dose dyskinesia remained unchanged. No abnormalities in laboratory values were found.

Benserazide↗

[Antibody detection in emergency transfusions. A comparison of 3 different methods].

We compared the manual Polybrene technique to three standard methods (albumin/Coombs, LISS/Coombs, and enzyme/papain) on 113 red cell antibodies. Polybrene identified 8 antibodies of the Rhesus system missed by standard methods, whereas 3 antibodies could only be detected by the standard techniques. Four antibodies were identified only in saline solution at room temperature; 6 were found by use of Polybrene exclusively in the additional Coombs phase. In addition, 61 antibodies were tested by 4 different LISS. No considerable differences in the quality of the various LISS were seen. The manual Polybrene test appears to be suitable for crossmatching and rapid antibody identification in emergency situations.

Blood Group Antigens↗

[Pain clinics].

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Acute Disease↗

[Autologous transfusion of blood deep frozen in the interim in childhood].

In the report we describe a method of reducing the number of transfusions of heterologous blood in patients with a surgical correction of chest walls. In 71 children between 2 and 17 years of age, 10-15% of total blood volume were withdrawn 3-4 weeks before the operation, deep frozen and thawed at the appropriate time to be ready for retransfusion. This arrangement reduced the need of heterologous blood significantly from 18.6% (prior to the introduction of the method) to 4.2%.

Adolescent↗

Madopar HBS: slow-release levodopa and benserazide in parkinsonian patients presenting marked fluctuations in symptoms on standard L-dopa treatment.

In this open study patients with advanced Parkinson's disease, who experienced pronounced fluctuations in symptoms while on standard L-dopa, were switched from Madopar/Sinemet to Madopar HBS. The dosage was adjusted until optimal response was obtained. The effect was unsatisfactory in 4 cases and side effects intervened in another 2. The remaining 16 patients exhibited substantial and frequently significant improvements with regard to both akinetic and dyskinetic phenomena. L-Dopa dosage was increased in all cases, and addition of standard L-dopa was required in one third of the cases. These benefits continued in the majority of patients.

Adult↗