This paper presents the case of a 65 year-old woman suffering from recurrent oral aphthoid ulcers which rapidly evolved towards hyperplastic and ulcerated lesions over the entire floor of the mouth. The initial lesions were interpreted as non-specific aphthoid ulcers. Later, a tentative diagnosis of necrotising stomatitis with secondary reactive proliferating epithelial hyperplasia was made. The clinical symptoms and the immuno-phenotyping of lymphocytes circulating in the peripheral blood suggested the diagnosis of CD30-positive large cell anaplastic lymphoma. The biopsy showed only a pseudoepitheliomatous hyperplasia, reactive infiltrates and no lymphoma cells. The disease ran a fulminant course leading to death within 4 weeks due to acute gastro-intestinal bleeding. Autopsy revealed infiltrates of CD30+ large cell anaplastic lymphoma in a submandibular lymph node, in a thrombus stenosing the right subclavian vein, in the spleen, the anterior and posterior gastric wall as well as in the depth of the tumour on the floor of the mouth. The clinical and histopathological spectrum of CD30+ large cell anaplastic lymphoma is considerably variable. The particular feature of pseudoepitheliomatous hyperplasia has been reported especially in CD30+ anaplastic large cell lymphomas. An early correct diagnosis is rendered difficult in insufficient biopsy size, becauses this type of lymphoma often simulates other inflammatory or neoplastic skin diseases. Thus, with a necrotising and hyperplastic gingivostomatitis, the diagnosis of a CD30+ anaplastic large cell lymphoma should be considered.

Aged↗

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Nail surgery.

Nail surgery is not particularly difficult but often delicate. Profound knowledge of the anatomy, physiology and pathology of the nail organ as well as surgical skills and atraumatic instruments are prerequisites for successful nail operations. Careful preoperative preparation of the patient as well as consistent post-operative care are necessary. The following article will give information about the essentials of nail surgery, such as adequate anaesthesia, instrumentation, and complications. The most frequently performed nail operations are described focussing on techniques proven to be safe and successful. Nail avulsions, ingrowing nail, myxoid pseudocysts and subungual exostoses as well as the treatment of haematomas and nail tumours are outlined. Ungual melanomas are the most frequent malignant tumours of the nail apparatus and deserve special attention. Some indications for cryosurgery, laser and electro-surgery are given.

Humans↗

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