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Biomedical subjects

E Ginter

Publications and source records attributed to E Ginter.

At least 91 records · Page 5Linked to original sources
PubMed1982

Vitamin C in the control of hypercholesterolemia in man.

The activity of the cholesterol 7 alpha-hydroxylating system containing cyto-chrome P-450 is depressed in the liver of guinea-pigs with chronic marginal vitamin C deficiency. Slowing-down of this rate-limiting reaction of cholesterol transformation to bile acids causes cholesterol accumulation in the liver, blood plasma and arteries, increase in the index total: HDL cholesterol, prolongation of plasma cholesterol half-life, increase in the index cholesterol: bile acids in the gall-bladder bile, cholesterol gallstone formation and atheromatous changes on coronary arteries in guinea-pigs with long-lasting marginal vitamin C deficiency. The most effective means for preventing these changes are vitamin C doses ensuring maximal steady-state levels of ascorbate in the tissues. In most of hypercholesterolemic persons with a low vitamin C status, the administration of ascorbic acid in doses 500-1000 mg per day lowers total cholesterol concentration in blood plasma. This effect may be reinforced through a simultaneous administration of bile acids sequestrants, such as cholestyramine or pectin. In every form of hypercholesterolemia therapy (dietary and/or pharmacological), an adequate vitamin C supply should be ensured in doses capable of creating maximal steady-state levels of ascorbate in human tissues.

Ascorbic Acid↗
PubMed1982

Synergism between vitamins C and E: effect on microsomal hydroxylation in guinea pig liver.

A separate administration of high doses of L-ascorbic acid or DL-alpha-tocopherylacetate to guinea pigs, fed a cholesterol diet with low content of vitamins C and E enhances the activity of aniline hydroxylase and p-nitro-anisole O-demethylase in hepatal microsomes. A simultaneous administration of the two vitamins exerts a synergic action on aniline hydroxylase. An optimum combination of vitamins C and E may substantially enhance the detoxicating ability of the liver.

Aniline Hydroxylase↗
PubMed1982

Kinetics of ascorbate depletion in guinea pigs after long-term high vitamin C intake.

Half-lives of ascorbate depletion in 9 organs proved the same in guinea pigs receiving minimum maintenance dose of ascorbic acid (0.5 mg/animal/day) during 15 weeks of the pre-experimental period, as in those on very high doses (0.5% ascorbic acid in diet = 300 mg/kg body weight/day). The survival on the ascorbate-free diet proved longer in guinea pigs receiving high vitamin C doses (0.5% in diet) for 7 months previously, than in those with a tenfold lower vitamin C supply (0.05% in diet). Permanently high vitamin C intake does not induce induce systemic conditioning in adult guinea pigs.

Animals↗