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E Espinosa

Publications and source records attributed to E Espinosa.

At least 127 records · Page 7Linked to original sources
PubMed1979

Occurrence of a thermostable antigen of ovarian carcinoma in normal tissues and secretions.

Thermostable antigen (TA) occurs in ovarian carcinoma and in certain specialized tissues. High titers of TA were found in nineteen of twenty endocervical extracts but not in myometrium, endometrium, or exocervix. TA was present in all of sixteen cervical mucus samples. Antibodies to perchloric acid extract of bronchus showed cross-reaticity with TA from ovarian carcinoma and cervix. Immunofluorescence with frozen sections revealed TA to be present in the columnar epithelium of ovarian neoplasms, and endocervical glands, in bronchial seromucous glands and in hepatic bile canaliculi. Immunofluorescence and immunodiffusion were used to test for cancer patient antibodies against TA. All sera tested negative. An immunofluorescence inhibition test for circulating TA also tested negative in sera of ovarian and cervical cancer patients.

Adult↗
PubMed1978

[Tissue antigens in ovarian carcinoma].

Five tissue antigens have been identified which appear in carcinoma arising in the ovary. Antisera to a variety of human tissues were absorbed with a saline extract of normal ovary as well as plasma; five distinct antigens (A1-A4, TA) were detected in ovarian tumor extracts as well as in normal tissues. A1, A2, and A3 were widely distributed in normal tissues while A4 was found principally in buffy coat blood cells and spleen, and TA was mainly associated with normal cervix but was variably detected in liver and lung. Heating the tumor extract to 56 degrees resulted in inactivation of A1, A2, and A3. A4 was inactivated at 80 degrees, whereas TA was stable at 100 degrees. Pronase treatment readily abolished A3 activity, more slowly inactivated A1, A2, and A4, and only very slowly destroyed TA. Partial separation of the antigens was obtained by Sephadex G-200 chromatography. TA from individual benign and malignant tumors as well as normal cervix appears to be the same molecule by criteria of immunodiffusion, immunoelectrophoresis, and gel filtration. The potential use of these antigens as tracers of ovarian carcinoma is indicated.

Antigens↗
PubMed1977

Tissue antigens in ovarian carcinoma.

Five tissue antigens have been identified which appear in carcinoma arising in the ovary. Antisera to a variety of human tissues were absorbed with a saline extract of normal ovary as well as plasma; five distinct antigens (A1-A4, TA) were detected in ovarian tumor extracts as well as in normal tissues. A1, A2, and A3 were widely distributed in normal tissues while A4 was found principally in buffy coat blood cells and spleen, and Ta was mainly associated with normal cervix but was variably detected in liver and lung. Heating the tumor extract to 56 degrees resulted in inactivation of A1, A2, and A3. A4 was inactivated at 80 degrees, whereas TA was stable at 100 degrees. Pronase treatment readily abolished A3 activity, more slowly inactivated A1, A2, and A4, and only very slowly destroyed TA. Partial separation of the antigens was obtained by Sephadex G-200 chromatography. TA from individual benign and malignant tumors as well as normal cervix appears to be the same molecule by criteria of immunodiffusion, immunoelectrophoresis, and gel filtration. The potential use of these antigens as tracers of ovarian carcinoma is indicated.

Antigens, Neoplasm↗
PubMed1976

Circulating tissue antigens. III. Identification and characterization of antigens of limited and of wide body is distribution in human gall bladder bile. Presence in serum of patients with acute hepatitis.

Three antigens shared by bile and tissues (BT-1, BT-2 and BT-3) and one shared by bile and saliva (BA) were identified in human gallbladder bile by immunodiffusion. The former were detected in all bile specimens examined, whereas the latter was detected only in half. BT-1 was limited in distribution to kidney, urine and bile; whereas BT-2 and BT-3 were widely distributed mainly in liver, lung and bile. The antigens were not present in biles of other mammals tested, with the exception of BA which was also present in Rhesus monkey. All antigens were inactivated by Pronase, had relative electrophoretic mobilities of serum globulins and separated from each other in Sephadex G-200 gel filtration and ammonium sulphate fractionation. Ethanol inactivated BT-1 and precipitated the other antigens. BT-2 and BA were relatively resistant to boiling temperature and acid pH, whereas BT-1 and BT-3 were susceptible. Antigens BT-2 and BT-3 were detected in serum of patients with acute hepatitis but not of patients with other diseases or of normal controls.

Antigens↗
PubMedDate not supplied

Circulating cancer cells in peripheral blood. A case report.

BACKGROUND: Carcinocythemia, the presence of circulating cancer cells in peripheral blood, is a rare complication of solid neoplasms. When the number of such cells is very high, they can be detected during routine laboratory tests. They are associated with a dismal prognosis. CASE REPORT: Carcinocythemia occurred in a patient with disseminated breast cancer. Eighteen cases were identified from a review of the literature. The most common neoplasms associated with circulating cancer cells in peripheral blood were breast adenocarcinoma, small cell lung carcinoma and rhabdomyosarcoma. All the patients had stage IV disease at the time of diagnosis, and all had involvement of the reticuloendothelial system. Patients survived for an average of a few days or weeks. CONCLUSION: Circulating cancer cells in peripheral blood are an unusual manifestation of disseminated neoplasms that occurs as a terminal event.

Adenocarcinoma↗
PubMedDate not supplied

[Behavior-immunity relationship: the role of cytokines].

There are several phenomena in which the immune and the central nervous systems regulate each other. However, their mechanisms are poorly understood. Since cytokines have a central role in the regulation of the immune response, this review describes their participation in two forms of neuro-immune communication, immunomodulation by psychological stress and behavioral conditioning of immune response. The role of cytokines in the endocrine and behavioral effects of acute phase, where cytokines have an effect in functions of the central nervous system, is also reviewed. The effects of psychological stress are described as both immunosuppressing and immunoenhancing. Among them, a relevant immunosuppressing one is the reduction of IL-1, IL-2, and IFN-gamma levels. In contrast, some of the pro-inflammatory effects of stress are mediated by an increase in the levels of IL-6, IL-1, and TNF mediated by the neurotransmitter Substance P. A possible role for IL-1 and IFN-beta as possible messengers in immune regulation by behavioral conditioning is proposed. Pro-inflammatory cytokines in turn can activate the hypothalamus-pituitary-adrenal axis and induce sickness behavior during the acute phase response, during which the parasympathetic nervous system serves as pathway for their detection by the central nervous system. An account is given about recent findings on the regulation of cytokine expression by neurotransmitters from the sympathetic nervous system (epinephrine and norepinephrine), a key piece in all these mechanisms of brain-immune communication. Possible mechanisms and pathways of communication between the brain and the immune system, as well as the possible participation of other cytokines are discussed.

Animals↗
PubMedDate not supplied

[Not Available].

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History, Modern 1601-↗
PubMedDate not supplied

[Febrile syndrome of unknown etiology].

The results of the analysis of 114 patients with fever over 38 degrees C with minimal duration of one week, are reported. There were no data from the physical examination to produce a nosological diagnosis. The greater number of age groups were for infants (43%) and school children (35%). There was a predominance in males (62.3%). There were histories of potential usefulness for the diagnosis in 39 patients, but only in 7 cases was it possible to establish a relationship with the illness. In 70 patients (61.4%) it was not possible to determine exactly the cause of fever. In the remaining cases, a distribution into three etiological groups was made: infectious or parasitic, collagenous disease and malignant neoplasia. Considerations are made on these groups and on the usefulness, for the diagnosis, of the type of fever graph. The course is analyzed and conclusions are established.

Adolescent↗