Biomedical subjects
E Ernst
Publications and source records attributed to E Ernst.
[Blood rheology as a risk indicator in cardiovascular diseases?].
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Regulation of cerebral blood flow in response to changes in blood viscosity.
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[Is hemorheologic therapy in cerebrovascular disorders ready for general practice].
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Blood viscosity--a comparative study on three rotational instruments.
Three rotational viscometers for blood viscometry were compared at moderate and high shear. At high shear, coefficients of variation were all around 1% increasing 5-fold (Wells-Brookfield) and 3-fold (Carri-Med) when shear was lowered. Using pathological samples the coefficients of variation for the Carri Med mashine was doubled. Only the Contraves LS-30 viscometer showed neither an increasing coefficient of variation with declining shear, nor problems when measuring blood with suspension instability.
Metallic mercury in the gastrointestinal tract. A case of ingested thermometer mercury.
In a healthy, intact gastrointestinal tract, metallic mercury cannot produce symptoms of systemic intoxication. If retained in the appendix, however, the mercury can cause local inflammation and--should penetration result--also systemic poisoning. A case is described in which ingested thermometer mercury was retained in the appendix and thereby constituted an indication for appendectomy.
[Improvement of blood rheology by intensive physical training].
In a comparative study of athletes and sedentary normal persons, it is shown that the former have significantly better hemorheological factors. In a follow-up study, it is further shown that in healthy subjects, an intensive training programme continued for a period of three months, leads to a lowering of blood viscosity, which is comparable with the effects that can be achieved with suitable hemorheological treatment.
[Principles of hemorheologic therapy].
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[Are "rheologic agents" therapeutically useful?].
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[Improvement of reduced erythrocyte flexibility through calcium dobesilate. Results of a pilot study].
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Effect of metoprolol on chest pain in acute myocardial infarction.
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Ketanserin treatment in essential hypertension.
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A new simple method for measuring red cell aggregation.
A viscometric technique is outlined for the measurement of red cell aggregation (RCA). Samples are submitted to a constant shear rate of 2,4 s-1. The resulting time dependent torque signal reaches a peak soon after starting the rotation and falls within seconds to a constant baseline, thereby describing an area "F" with the baseline. The shear history of the sample being strictly controlled, "F" is reproducible and shows a direct, positive correlation with RCA as determined for instance in the "aggregometer".
Hyperthermia and cancer chemotherapy.
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Hematocrit and plasma volume in runners.
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Modification of transoperative changes in blood fluidity by hydroxychloroquine: a possible explanation for the drug's antithrombotic effect.
A study was carried out in 40 patients undergoing minor surgery to investigate the effect of hydroxychloroquine on haemorrheological parameters which might explain its reported anti-thrombotic action. Twenty patients received 600 mg to 1400 mg hydroxychloroquine sulphate in the 48-hour period before operation and the control group of 20 patients received placebo. Blood samples were taken during the 24 hours before and on the day after operation. The results showed that in the hydroxychloroquine-treated group the transoperative increase in fibrinogen was associated with a reduction in plasma viscosity compared with an increase in the control group. Furthermore, the mean value for whole blood viscosity at middle shear rate decreased post-operatively in the drug-treated group whereas it increased in patients who had received placebo.
[Therapeutic defibrinogenation as conservative therapy of peripheral arterial occlusive disease. A critical analysis].
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