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Biomedical subjects

E Eriksson

Publications and source records attributed to E Eriksson.

At least 379 records · Page 21Linked to original sources
PubMed1977

Microvascular effects of a topically applied cationic triphenylmethane dye (crystal violet).

The effects of local application of crystal violet on the microcirculatory system are reported. The testing system consisted of vital microscopy of the cheek pouch of the hamster and microangiography of rabbit's ear. It appeared that the early microcirculatory disturbances caused by a dilute aqueous solution of crystal violet were transient, whereas considerable tissue toxicity was shown in the long-term experimental model. A direct cytotoxic effect is suggested.

Angiography↗
PubMed1976

Hydrophobic surface properties of erythrocytes studied by affinity partition in aqueous two-phase systems.

Erythrocytes from various species have been partitioned in aqueous two-phase systems consisting of water, dextran, poly-(ethylene glycol), salt and buffer. The terminal hydroxyl groups of the latter polymer were esterified with palmitic, oleic, linoleic and linolenic acids, as well as with deoxycholic acid. In a two-phase system containing unesterified poly(ethylene glycol) the erythrocytes are exclusively in the dextran-rich lower phase. When the poly(ethylene glycol)-rich upper phase depending on the type and concentration of esterified acid. Palmitate ester is most effective in increasing the affinity of the cells for the upper phase, followed by oleate, linolate, linolenate, and deoxycholate esters. The partition behaviour of erythrocytes from various species differs considerably. Two groups can be distinguished: one consisting of erythrocytes from dog, guinea pig and rat, the other from human, sheep and rabbit. This division can be correlated to the content of sphingomyelin and phosphatidyl choline in the erythrocyte membranes.

Animals↗
PubMed1976

Reconstruction of the anterior cruciate ligament.

A report is given of a personal series of 72 cases of injury of the anterior cruciate ligament, reconstructed by use of modifications of the Jones procedure. After one year, stability of the knee without a drawer sign was obtained in 80 per cent of the cases.

Adult↗
PubMed1976

Ski injuries in Sweden: a one year survey.

In a study of ski injuries in Sweden in 1973-1974, information regarding 1199 ski injuries was obtained. Downhill skiing was responsible for 75 per cent of the injuries. Cross country skiing proved to be a safe sport. Poor adjustment of release bindings, skiing at too high a speed, and deficiencies in the slopes were the most common causes of injury. The investigation led to an information program that seems to have reduced the injury rate by 25 to 30 per cent.

Age Factors↗
PubMed1976

Active immunization against tetanus in man. II. Combined active and passive prophylaxis with human tetanus immune globulin.

19 Persons were actively immunized with adsorbed tetanus toxoid and were simultaneously given tetanus immune globulin of human origin, TIG(H), in doses of 500-1500 IU. Their antitoxin titres were followed for 1 year. Seven persons were given only TIG(H), 500 IU and 1500 IU and their antitoxin titres were followed for 3 months to 1 year. For comparison, 30 military recruits were actively immunized with adsorbed tetanus toxiod according to common practice. Their antitoxin titres were followed for 1 year. The response to complete active immunization could not be demonstrated to be impaired by passive immunization, when 500 IU or 1500 IU OF TIG(H) were given simultaneously with toxoid. The titres were in accordance with those achieved by active immunization of the recruits.

Adult↗
PubMed1975

Active immunization against tetanus in man. I. Duration of anamnestic reaction after one dose of vaccine.

Fifteen men, 30-40 years old, who had received one dose of vaccine against tetanus, were given a booster dose 8-13 years later. Their serum content of tetanus antitoxin was determined (1) before the booster dose, (2) 3-4 days and (3) 8 days after the booster dose. A control group of ten men with 2-3 earlier vaccine injections was treated in the same way. All the men in the first group had an antitoxin content of 0.01 IU/ml or more, 8 days after the booster dose, while the comparative titres increased to more than 1 IU/ml in the control group. The advantage of a complete basic immunization is obvious, but the investigation shows that, even after one injection, the titre after a booster dose increased to a generally accepted protective level.

Adult↗
PubMed1975

Varicose ulcers.

The results of a combined dermatological and surgical treatment of varicose ulcers was studied in 100 patients. This chronic disease, often persisting for decades, was halted in 90 percent of leg operated upon. Even when the general outcome of the treatment was favourable, it was found that, for 5 out of the 12 ulcers which were the same or larger in size at follow-up than before operation, the patient assessed the result as good or even excellent. This finding deserves further study. It indicates that patients and physicians sometimes use different standards by which to measure therapeutic success.

Aged↗
PubMed1975

Hepatitis B immune serum globulin in prevention of hepatitis B among hospital personnel. Preliminary report from a controlled trial.

At Sahlgren Hospital, Göteborg, hepatitis B has been a serious problem for several years among the personnel in the hemodialysis and renal transplantation wards as well as in the chemical laboratories. For this reason a randomized controlled clinical study with conventional gammaglobulin and hepatitis B immune globulin was started in May 1973. The titer of anitbodies against HBsAg by passive hemagglutination was 1:100 and approximately 1:350,000, respectively. Newly employed staff without a history of jaundice and without demonstratable HBsAg (RIA) or HBsAb (RIP) in serum were enrolled in the trial. Assignment of the two preparations was performed by random numbers and the ampoules were labelled only with the serial number of the participant. Three cc of either preparation was administered i.m. within seven days after admission and was repeated three months later. After that no further injections were given. Each participating employee was followed up with liver function tests, IEOP, RIA and RIP tests for at least six months after the last injection. Preliminary results from this double-blind study, which is still going on, are presented.

Clinical Trials as Topic↗