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Biomedical subjects

E Eriksson

Publications and source records attributed to E Eriksson.

At least 325 records · Page 18Linked to original sources
PubMed1983

Breast construction in Poland's syndrome. Case report.

A patient with Poland's syndrome underwent breast construction. Transposition of a latissimus dorsi muscle flap, implantation of a silicone prosthesis and correction of ptosis of the other breast was done with a satisfactory result.

Abnormalities, Multiple↗
PubMed1982

Up- and down- regulation of central postsynaptic alpha 2 receptors reflected in the growth hormone response to clonidine in reserpine-pretreated rats.

The alpha-adrenergic mechanisms exert a stimulatory influence on the secretion of growth hormone (GH) in the rat. In the present study the alpha receptors involved in GH regulation were characterized with respect to subtype. It was also investigated whether the GH response to alpha receptor agonists can be utilized to assess change in the responsiveness of central alpha receptors. The experiments were performed on rats with implanted intra-aortic cannulae allowing frequent blood sampling from freely moving animals. Plasma GH was determined by radioimmunoassay. Reserpine (10 mg/kg) caused a suppression of the normal pulsatile secretory pattern of GH. The alpha receptor agonist clonidine (CLON) given to reserpine-pretreated animals induced a dose-dependent increase in plasma GH. The effect of CLON (0.2 mg/kg) was prevented by pretreatment with the alpha 2 receptor antagonist yohimbine (3 mg/kg), but not by the alpha 1 receptor antagonist phenoxybenzamine (10 mg/kg). Chronic pretreatment with CLON or imipramine, either of which can be expected to produce a reduced sensitivity of central alpha 2 receptors, resulted in reduced GH responses to CLON. On the other hand, chronic treatment with yohimbine, which should cause denervation supersensitivity of alpha 2 receptors, led to enhanced GH responses to CLON. The results indicate that GH release in the rat is stimulated by postsynaptic alpha 2 receptors. They also suggest that the GH response to CLON can be used as a valid in vivo model reflecting decreased, as well as increased responsiveness of this type of receptor.

Animals↗
PubMed1982

Effect of cold water immersion on oedema formation in the scalded mouse ear.

One ear of adult white NMRI hairy mice was first scalded and then immersed in cold water in order to study the effect of cooling on oedema formation. Oedema was determined by wet-dry weight measurements of punch biopsies from the ear and expressed as an increase in tissue water content. The temperature of the cold water was 8 degrees C and periods of cooling from 15 to 240 minutes were used. The contralateral ear and the quadriceps muscle were used to study distant effects of scalding and cooling. After scalding, significant oedema was found in the burned ear. Cooling for 30 minutes gave a significant reduction of oedema in this model. Shorter or longer periods of cooling did not reduce oedema significantly. Cooling did not influence the oedema formation of the contralateral (unburned ear). Neither scalding nor cooling changed the water content of the muscle.

Animals↗
PubMed1982

Effects of gonadectomy and testosterone replacement on growth hormone response to alpha 2 adrenergic stimulation in the male rat.

The growth hormone (GH) response to clonidine in reserpine-pretreated rats is a putative in vivo model to reflect activation of central postsynaptic alpha 2 receptors. In the present study the influence of testosterone on the responsiveness of central alpha 2 receptors was investigated using this method. One week after operation the GH response to clonidine was drastically reduced in gonadectomized adult male rats compared to sham-operated controls. Testosterone replacement completely antagonized the effect. The results suggest an influence of testosterone on central postsynaptic alpha 2 receptors or on structures connected to these receptors.

Animals↗
PubMed1982

Surgical results in 477 basal cell carcinomas.

The hospital records of 406 patients treated for basal cell carcinomas were reviewed. Seventy-nine percent of the tumors were located to the head and neck area. All tumors were excised with a macroscopic margin of at least 3 mm. The surgical defects were closed primarily in 351 cases (74%), skin grafted in 108 cases (22%) and covered with local flaps in 18 cases (4%). Twenty patients (4%) required re-excision because of microscopically inadequate margins. Recurrence of the tumor was seen in 11 patients (2%).

Adult↗
PubMed1982

Advanced cancer of the vulva treated by vulvectomy and proctectomy. Case report.

In 5 selected patients with squamous cell carcinoma of the vulva invading the anus, a vulvectomy in combination with proctectomy and in three cases bilateral groin dissection en bloc, was performed. All five patients had microscopically well differentiated tumors and no one showed evidence of distant metastases. All five patients are now alive and well with a mean observation time of 8 years. It is concluded that in selected patients, extensive surgery for invasive squamous cell carcinoma of the vulva can be very rewarding.

Aged↗
PubMed1982

Anti-coagulant and anti-thrombotic effects of some protease inhibitors.

Several synthetic tri-peptide enzyme inhibitors of the general sequence Phe-Pro-Arg were studied in vitro and in vivo. Extent and specificity of inhibition of thrombin were different. The inhibitors exert anti-coagulant effects in vitro. The anti-coagulant effect in vivo was used as a measure of bioavailability and duration of action. The tri-peptide inhibitors are rapidly eliminated from the circulation and produce a decrease in blood pressure. Anti-thrombotic effects were demonstrated in a thrombosis model in rabbits.

Animals↗
PubMed1982

Arthroscopy and arthroscopic surgery in a gas versus a fluid medium.

A comparison of arthroscopy in fluid and gas was performed in 50 consecutive knee arthroscopies and in 38 arthroscopies of other joints. Gas was found to give the same information as fluid in about two thirds of the knees and shoulders and to give better information than fluid in one third of patients. In elbows, hips, and ankles gas proved to be better than fluid in 52 percent of patients. The advantage of gas over fluid is that it allows a better study of the degeneration of the joint cartilage and that it presses the synovial folds down, allowing better inspection of small joints. Operative arthroscopy is fully possible in gas and may offer some advantages over operative arthroscopy in fluid.

Ankle Joint↗
PubMed1982

Surgical treatment of carcinoma of the vulva.

In a prospective study, 169 patients with invasive squamous cell carcinoma of the vulva were treated by radical surgery. One hundred patients, without palpable inguinal lymph nodes, had a vulvectomy only, and the remaining 69 underwent vulvectomy in combination with groin dissection. Different prognostic factors were analyzed, and the results of radical surgery were evaluated. It was found that a small, exophytic, microscopically well differentiated tumor confined to one anatomic area will carry the best prognosis. Conversely, a patient with a large, endophytic, poorly differentiated tumor with inguinal lymph node metastasis will have the least favorable outcome. If there is metastatic spread to the deep inguinal node, Rosenmüller, the prognosis is quite bad. The crude five year survival rate was 56 per cent and the corrected survival ate was 65 per cent. Eleven patients died of early complications, seven of pulmonary embolism. It was concluded that radical surgery gives the best cure rate. It is suggested that operation for invasive squamous cell carcinoma of the vulva in all patients should consist of vulvectomy with primary skin grafting and bilateral superficial inguinal gland excision en bloc.

Adult↗