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Biomedical subjects

E E Polli

Publications and source records attributed to E E Polli.

At least 91 records · Page 5Linked to original sources
PubMed1980

Plasma immunoreactive N-terminal parathyroid hormone and cyclic AMP and cyclic GMP urinary levels in man after I. M. administration of two different doses of porcine calcitonin.

The effects of acute porcine calcitonin (pCT) administration were studied in 11 healthy volunteers with no metabolic disease. Each subject was given, intramuscularly, 1 MRC unit of pCT in glycine vehicle, 160 units of pCT in gelatine vehicle, and placebo, according to a crossover design. The following parameters were studied: blood calcium, phosphorus and immunoreactive parathyroid hormone (iPTH); urine calcium, phosphorus, cyclic AMP and GMP. Both the pCT preparations produced, at the same time after administration, a hypocalcemic effect (P less than 0.01) which was not dose related, without any modification of urinary calcium excretion, implying that both doses are able to inhibit completely bone destruction. Despite the blood calcium decrease, no significant modifications in plasma iPTH levels were observed. pCT administration did not modify the urinary excretion of cyclic AMP, while it increased the urinary levels of cyclic GMP, particularly at the higher dose employed. Blood phosphorus decrease and urinary phosphate excretion increase were observed only after the administration of 160 MRC units of pCT. These observations suggest that the effects on urinary cyclic GMP and on blood and urine phosphorus are not mediated by PTH but could be the result of a direct action of calcitonin seen only when high doses are employed. In conclusion, one MRC unit of pCT is sufficient to inhibit bone resorption.

Adult↗
PubMed1979

A controlled study of the effect of sulfinpyrazone on platelet survival and on platelet-bound 14C-serotonin release in patients with previous myocardial infarction.

Preliminary data obtained in the ambit of Anturan Reinfarction Italian Study (ARIS) show that, in postmyocardial infarction, reduced platelet survival time occurred in hyperbetalipoproteinemic patients treated with placebo, but not in the group of patients treated with sulfinpyrazone (interaction between treatment and lipemic level is at p approximately equal to 0.1). The sulfinpyrazone effect on platelet survival is probably related to the release reaction inhibition as suggested by our ex vivo results on platelet-bound 14C-serotonin release.

Adult↗
PubMed1978

Results of the therapy of acute leukemia. A cooperative trial by the Italian Association Against Leukemias.

Protocol 7401 for the treatment of acute lymphoblastic leukemia was carried out by the study group of the Italian Association Against Leukemias. The 157 patients studied were divided into two groups--over and under 20 years of age. Patients reaching complete remission were then randomized into one of the two maintenance chemotherapy regimens (A or B). Complete remission was attained in 92.3% of 117 evaluated patients. Ninety-five patients aged under 20 years entered the maintenance regimen; 60% were in complete remission after three years. Computer processing and multiple regression analysis have shown that age, lymph node involvement and the percentage of periodic acid-Schiff-positive blast cells may have prognostic value. However, with the Logrank test it was possible to compare the two maintenance regimens in each group for each prognostic factor. Patients aged between 2 and 10 years responded better to regimen A than to regimen B, as did patients with mild lymph node enlargement. Since some of the host-related factors studied emerged as significant for remission duration, three new protocols taking these prognostic factors into account were started. After one year, actuarial curves showed that 91% of 80 patients in Protocol 7601, 70% of 32 patients in Protocol 7602, and 82% of 33 patients in Protocol 7603 were in complete remission.

Adolescent↗
PubMed1978

In vitro growth of human myeloid leukemia bone marrow cells in liquid culture.

The myelopoietic cell growth, proliferation and differentiation of human bone marrow cells from 20 acute leukemia patients and 12 control subjects were studied by the diffusion chamber technique. The differences in proliferation patterns between normal and leukemic marrow cells are reported. Acute nonlymphatic leukemia cells do not differentiate in vitro, and retain the cytochemical characteristics of the inoculated cells. Leukemic blasts grow to form agglomerates while normal or more differentiated cells produce a population diffused over the membrane. No colony-stimulating factor is necessary for growth to occur, even for the leukemic population, which is unable to produce colony-stimulating activity.

Adult↗
PubMed1976

[Evaluation of the effects of some non-steroid anti-inflammatory agents on the gastric mucosa].

300 mg/day phenylbutazone, 210 mg/day indomethacin, and 600 mg/day pyrasanone were administered for 14 days to three randomised groups of patients respectively, consisting of a total of 76 subjects with various forms of non-infectious inflammation (osteoarthritis, fibrositis, rheumatoid arthritis, gout, phlebitis), in a double-blind trila designed to determine the activity of the three drugs and their tolerance. In 36 cases, gastroscopy was performed before and after the treatment. On the basis of doses that were equivalent as far as their anti-inflammatory effect was concerned, epigastric pain and pyrosis were noted in about 31% of the series, though no significant difference could be made out between the three drugs. Gastroscopic evidence of erythema (8 cases), multiple erosion (2 cases), pomphoid gastritis (1 case), and duodenal ulcer (1 case) was obtained in subjects treated with phenylbutazone or indomethacin, and of erythema only (1 case) after pyrasanone. No relation could be established between the clinical symptoms and the gastroscopic findings.

Anti-Inflammatory Agents↗
PubMed1975

In vitro production of lymphocyte and granulocyte proliferation inhibitors (chalones?) from living cells.

Media conditioned with viable rat and calf spleen lymphocytes were seen to be able to inhibit 3H-thymidine uptake by rat thymocytes and the mitogenic response of human lymphocytes to PHA but not bone marrow cells proliferation. The inhibitor appeared to have a molecular weight greater than 50,000 daltons, as determined by Amicon Diaflo ultrafiltration. Media conditioned with rat granulocytes had a similar tissue specific but species non-specific inhibitory action. Also human leukemic cells appeared able to produce in vitro an inhibitor of cell proliferation when a certain degree of differentiation was present.

Animals↗