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Biomedical subjects

E Dupont

Publications and source records attributed to E Dupont.

At least 253 records · Page 14Linked to original sources
PubMed1977

Theophyllamine and the antiparkinsonian response to levodopa treatment.

In an open preliminary study theophyllamine (theophylline-ethylenediamine) was administered to eight patients with idiopathic parkinsonism showing residual signs of parkinsonism though already in treatment with levodopa. Although theophyllamine in preclinical studies was found effective in potentiating the response to central dopamine stimulation, the drug in the present clinical study was without effect on idiopathic parkinsonism. After a loading dose of aminophylline, 5.6 mg per kilogram given intravenously, a maintenance dose of 0.9 mg per kilogram per hour infused during 2 h resulted in serum levels of theophylline of 23.5 +/- 3.9 mg per liter. 3-methyl-xanthine, a pharmacodynamic active metabolite of theophylline was analyzed in the serum samples. Less than 0.5 mg per liter was found.

Aged↗
PubMed1977

Assessment of whole blood for antibody-dependent cell-mediated cytotoxicity in kidney patients.

A test using whole blood for antibody-dependent cell-mediated cytotoxicity has been assessed in kidney patients. The antibody-coated target system comprised lymphocytes isolated from a normal donor sensitised with rabbit anti-human lymphocyte serum. Comparison of results obtained with whole blood and isolated lymphocytes from the same patients shows that the whole blood test amplifies the differences between normal subjects, dialysis and transplant patients. It probably combines the effects of depressed lymphocyte function and lymphopenia and thus represent a more physiological in vitro correlate for in vivo immune function.

Antibodies↗
PubMed1977

Kidney graft rejection crisis: time-evolution, prognostic significance and role in infection.

For 255 kidney grafts performed during the past twelve years, 622 rejection crises (RC) were analysed. Irreversible RC occurred more frequently in second than in first grafts during the first post-operative trimester. A clear relationship between long term graft tolerance and RC occurring during the first post-operative month was observed. Infection was related to RC in 61% of cases. Infections following corticosteroid therapy after short intervals were usually characterised by a poor prognosis. These clinical features have practical implications for immunosuppressive treatment.

Adult↗
PubMed1976

Parkinson's disease treated with Sinemet or Madopar. A controlled multicenter trial.

92 patients with Parkinson's disease not previously treated with levodopa were considered as eligible for this triple-blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar) or levodopa + carbidopa ratio 10:1 (Sinemet) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side-effects occurred daily maximum dosage of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. The effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. The frequency of gastrointestinal side-effects and involuntary movements were significantly higher and more severe for Sinemet than for Madopar. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side-effects without concurrent lower efficacy remains open to speculation. The treatment schedules did not differ with regard to other side-effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.

Aged↗
PubMed1976

Kidney transplantation in primary oxalosis.

A 33 year old patient with primary oxalosis was submitted to cadaver kidney transplantation after 15 months treatment by hemodialysis. During the dialysis period, he developed complete heart block which immediately followed bilateral nephrectomy. The transplant functioned correctly and was found to excrete large amounts of oxalate. Death, which supervened 7 months after transplantation, was due to miliary tuberculosis. The patient's own kidneys and various organs examined post mortem showed extensive oxalate deposits, which were mainly observed in the graft, conducting system of the heart, ocular structures, spleen and pancreas. The problems of managing terminal uremia secondary to primary oxalosis are discussed.

Adult↗
PubMed1975

Levodopa alone and in combination with a peripheral decarboxylase inhibitor benserazide (Madopar) in the treatment of Parkinson's disease: A controlled clinical trial.

A combination of levodopa and the extracerebrally acting decarboxylase inhibitor benserazide (ratio 4:1) (Madopar), was compared with levodopa alone in a controlled double-blind clinical multicenter trial on 94 patients with Parkinson's disease. During 4 months of therapy levodopa + benserazide proved superior to levodopa on several accounts. Nausea and vomiting occurred with statistically significant less severity and frequency. Clinical improvement expressed through improvement in Webster rating occurred sooner and was all together greater. The treatment schedules did not differ with regard to other side effects, in particular involuntary movements and reduction in supine blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters.

Adult↗