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Biomedical subjects

E Dinya

Publications and source records attributed to E Dinya.

25 records · Page 2Linked to original sources

[Relationship between the caries status and metabolic imbalance in diabetics].

The dental clinical examination of 1600 (815 insulin dependent of type 1 and 761 non-insulin dependent of type 2 respectively) patients cared of because of diabetes mellitus was carried out and an answer to the question was sought for whether the condition of the teeth does change according to he type of the metabolic disturbance of the diabetic, the time of its manifestation, its setting, the manner of therapy, the family occurrence of the illness and the mouth hygiene, respectively. According to examination results, greater edentulousness with diabetes over 30 years showed a positive interdependence according to the confirmance time of diabetes. On the other hand, with diabetic of better setting there were less teeth with caries or removed ones and the DMF-T average was lower than with patients with worse diabetes setting. No independence was found in the development of the DMF-T average and the caries conditions, respectively, if diabetes occurred in the family history and according to the type of diabetes.

Adolescent↗

[Caries status in diabetic patients].

Clinical dental examination of 1600 diabetics (815 type 1 insulin dependent and 761 type 2 non-insulin dependent patients) has been performed according to the WHD criteria. According to examination results higher DMF mean value, less uncared of teeth with caries (D) and, in the age group of 19 years and above 30 years, more edentulousness has been found than with healthy individuals. The number of filled and crowded teeth (F) below the age of 35 years in diabetics (p 0.0001), above 45 years in the control group (p 0.0001) was higher. Concerning cared of teeth there was no deviation in the number of filled teeth between diabetic and healthy individuals whereas the number of crown covered teeth was higher with diabetics. (p 0.01). As to the distribution of individuals with healthy teeth and toothless ones it was found characteristic that while among diabetic individuals but 1%, in the control 1.4% possessed retained healthy teeth. The number of completely toothless individuals was higher (11.83%) with diabetics than with healthy individuals (2.25%).

Adolescent↗

[Possible cause of the increased incidence of lung cancer in 1987 in the 10th District of Budapest (1975-1989)].

In 1975 in one of the major industrial districts of Budapest some longitudinal epidemiological examinations were carried out with the aim of, among others, determination of connection between environmental injuries and lung cancer incidence in connection with determination of lung cancer risk groups. Between 1975-1989 out of the environmental injuries the most important was the radioactive contamination observed due to the atomic power station catastrophe in Chernobil (1986). In 1987 the incidence of lung cancer increased. The increase was significant among the 50-69-year-old women, and expressly among the heavy smokers. In 1987, especially among women, but also in both sexes, the ratio among the major cell types of lung cancer shifted towards micro-cellular ones. In 1988 and 1989 lung cancer incidence has decreased. In view of the above a hypothesis was raised: patients who have previously suffered immunobiological hurt, could not prevent the increased radioactive burden and got ill with lung cancer earlier, than it should have been happened without this increased burden. For clarification this question further examinations are considered to be necessary.

Aged↗

[The role of risk factors in the development of lung cancer of various cell types].

Between 1975 and 1978 in 10th district of Budapest a basis examination was carried out with the aim of determination of lung cancer risk factors. Out of the 30,566 inhabitants 403 persons got ill with lung cancer during the above mentioned period. In case of 321 patients the cell type was determined in detail. As to the connection between the main risk factors and the various cell types it was found that planocellular lung cancer can be regarded as the cell type of men, but exclusively of smokers, while the microcellular type lung cancer can be considered as cancer of not only the younger age-groups, but that of expressly women, especially heavy smokers. With elimination of the two main risk factors (smoking, pulmonal lesions) not only the number of patients with lung cancer could be decreased to one third, but the ratio of adenocarcinomic diseases would also increase. These diseases are more favourable in respect of operability and survival.

Adenocarcinoma↗

[Limitations and possibilities of detecting lung cancer by fluoroscopic screening of the population].

In 10th district of Budapest a longitudinal, epidemiological examination was started in 1975 with the aim of analysis of the objective factors influencing the population screening and determination of possibilities of screening effectiveness. It was found that effectiveness of lung cancer detection with screening depends on the tumour cell-type, as well as on the localization being in connection with same. By computer method based on mathematical modelling the population can be divided into the following groups: risk-free, moderate-risk, high-risk and superhigh risk groups. The screening was said to be absolutely unnecessary in risk free groups and in case of persons over the age of 70 irrespective of their risk factor status. The material savings resulting from the reduction of screenings can be assigned to introduction of complex methods. The switch-over from quantitative screening to the qualitative one can increase the effectiveness of lung cancer detection.

Fluoroscopy↗

Comparative study between the free radicals and tumor markers in patients with gastrointestinal tumors.

The tumorous processes, increased level of tumor markers and the change of free radical status are associated in patents with gastrointestinal tumors. The aim of this study was to examine free radical status and tumor markers in patients with gastrointestinal tumors. Two hundered and thirteen patients with gastrointestinal tumor were examined. In the control group 44 non-tumorous patients were examined. The tumor markers (CEA, CA 19-9, CA 72-4, AFP, TPA, AGP) and free radical status (total scavenger capacity) were diagnosed using venal blood (obtained by LIA-kits and chemiluminescent methods, LIA-mAT and the Lumat Berthold instrument). It has been found that: (1) The results showed that the tumor markers, TPA and AGP are the best indicators for the tumorous process; (2) The AGP serum level was in the operable case 91.56+/-38.29 mg/dl meanwhile its value was, 128.46+/-47.62 mg/dl (P<0.001) in the inoperable case; and (3) The TPA value was 118.37+/-155.47 mg/dl in the operable case, (P<0.001) while its value was 227.32+/-244.39 mg/dl in inoperable cases. The significantly high levels of the plasma Chemiluminescent Light Intensity (CLI)=28.12+/-25.96; was obtained in patients with rectal tumors vs. in the control cases CLI= 4.27+/-5.12 RLU% (Relative Light Unit; mean+S.D.; P<0.005). In six of these cases, the free radical status examination indicated the presence of the tumor, even though the level of tumor markers was normal. It has been concluded that the testing of both regular tumor markers and free radical status has an important role in the diagnosis and monitoring of the patients with gastrointestinal tumors.

Adult↗