Search PubMed⌕ Search

Biomedical subjects

E Dinya

Publications and source records attributed to E Dinya.

At least 19 recordsLinked to original sources
PubMed2000

[Increase in prevalence of childhood asthma in Budapest in relation to the air pollution data and the total pollen count].

The authors surveyed the prevalence of bronchial asthma in childhood in Budapest in 1995 and in February 1999, via questionnaires directed to paediatricians. In 1995, replies were received from 118 paediatricians in 11 districts, who were responsible for the supervision of 104,087 children, of these, 1.88 +/- 0.87% had been diagnosed as having asthma. In 1999, replies were sent by 153 physicians in 22 of the 23 districts, who had a total of 142,684 children under their care. These included 3228 asthmatics, i.e. a prevalence of 2.26 +/- 0.95%. The difference between the two data was highly significant (p = 0.0001). The prevalence increased by 20% in 4 years. The dust, CO, NO2 and SO2 concentrations in the air were measured constantly at 8 points in Budapest, while ozone level measurements were also made at 2 stations. The counts of pollens and of fungal elements in the air were calculated separately for Buda and for Pest. These data overall revealed that the level of air pollution in Budapest did not deteriorate in the period in question, and the pollen counts from allergizing plants did not rise relative to earlier years. An interesting question (though it is far from certain that this is a causal correlation) can be upposed whether the 13% drop in the number of live births in Hungary during this 4-year period can be connected with the 20% rise in prevalence of childhood asthma.

Adolescent↗
PubMed2000

Prediction of early renal graft function by the measurement of donor urinary glutathione S-transferases.

BACKGROUND: We have investigated the possibility of urinary alpha- and pi class glutathione S-transferases (GST-a; GST-pi) serving as a valuable parameter to predict early graft function after transplantation. METHOD: Urinary GST concentrations of 61 donors (DON) and recipients (REC) were analyzed at preoperative, intraoperative, and postoperative periods. We grouped recipients according to the early postoperative graft recovery days. RESULTS: The donor graft function, represented by the donor urinary GST concentration (GST-pi:17,1+/-12 microg/l mmol creatinine (crea); GST-a:14,3+/-10 microg/mmol crea), sustained a loss in comparison to the healthy controls (GST-a; pi< or =1 microg/mmol crea). According to statistical analysis, the donor GST-pi level showed a strong correlation with graft recovery days-pi (r = 0.84; P<0.001). The early graft function cannot be predicted by means of cold ischemia time (22.8+/-3.4 hr), nor handling time (42.4+/-11.1 min), nor even the intraoperative enzyme concentrations. The GST-pi cut off level (12.55 microg/mmol crea) might predict the possible posttransplant graft dysfunction. The discriminative analysis showed that using only DON GST-pi alone could discriminate well between the groups among all grafts in 68%. CONCLUSION: Prognosis is poorer if the donor GST-pi concentration is above 12.55 microg/mmol crea. On the basis of the determination of GST-pi concentration in the donor urine, we can predict graft viability before the surgical procedure with a reliability of 68%.

Adult↗
PubMed1998

[Biometry: data scales].

In this paper the author shows the basic concepts of the different data scales, which are important from statistical investigations points of view. He summarizes the characteristics of each scale and presents their sample data.

Biometry↗
PubMed1998

[Biometric concepts and function theory].

r shows the basic concepts of function theory, which ones are necessary in biometrical works. The concept of the function, the different mapping methods and some often used function types are presented.

Biometry↗
PubMed1998

[Basic concepts of biometric bases of the set theory].

In this paper the author shows the basic concepts of set theory, which ones are necessary to understand biometric methods. The sets, the most important operations, the power of sets and the types of the used variables are presented.

Biometry↗
PubMed1997

[Prospective epidemiologic study for the determination of lung cancer risk groups (1975-19940].

Authors make known the comprehensive results of a longitudinal epidemiological examination which commenced in the 10th District of Budapest with nearly 100,000 inhabitants in 1975. The observation period is 15-20 years. Its aim was the determination of the risk factors of lung cancer. They followed up the lot of 30,561 persons, 92% of the population over 40 years of age 14,191 patients took part in a control examination supplemented with respiratory test. They analysed the connection between the supposed external risk factors and parenchyma functional damages caused by them and the development of lung cancer by detailed mathematical statistical arithmetic. 571 patients fell ill with lung cancer. The cured lung tuberculosis also proved to be a leading risk factor besides smoking. From the not endangered group 43, the highly super highly endangered groups 458 people fell ill with lung cancer. There was no difference between men and women in the lung cancer risk of the risk free population. According to their supposition the connection between the parenchyma functional damages caused by external risk factors and the development of lung cancer is determined by the different immunological status of people. (During the 20 years observation period 4% of heavy smokers and 3% of cured lung tuberculous patients fell ill with lung cancer). They urge the organization of wide ranging international prospective examination for the testing of this supposition.

Epidemiologic Methods↗
PubMed1995

[Molecular genetic markers of Alzheimer dementia].

Alzheimer's dementia (AD) is a progressive neurodegenerative disease which is one of the most common forms of dementia in the above 65 years old age group. Diagnosis is based upon evaluation of cognitive skills, elimination of other dementia associated diseases and on cranial CT examination. However, definitive diagnosis is proved only by neurohistological findings. The etiology of the disease is unknown and effective treatment is not available. Intensive research into the pathomechanism of the disease revealed a connection between increased frequency of apolipoprotein E4 allele and later onset of AD. The aim of the author's research was to characterize apolipoprotein E polymorphisms in AD patients and to examine immunological factors which could play an important role in the development of the disease such as the polymorphism of complement and lipoprotein(a) [Lp(a)] alleles previously had not been investigated. 35 AD patients (26 female, 9 male) were examined (mean age 66.4 years +/- 8.7 SD). 18 of these patients showed late onset of the disease. The E4 allele was significantly more frequent in both early and late onset groups compared to controls (0.29 vs. 0.14 and 0.33 vs 0.09). The high frequency of apo E4 found in the early onset group in this study differs from other international data. Serum lipid, lipoproteins, Lp(a) concentrations and Lp(a) phenotype distribution showed no significant difference compared to controls. Furthermore, it was found that the frequency of complement C4AQ0 (null) and Bf F alleles was higher in the late onset AD group compared to controls (0.35 vs 0.139 and 0.305 vs. 0.225) suggesting an active involvement of the complement system in the pathogenesis of this disease.

Age Factors↗
PubMed1995

[Could tuberculosis again be an endemic disease in Hungary? (Model study 1968-1993)].

The aim of this examination started in an industrial district of Budapest with 100,000 inhabitants in 1968, was the determination of risk groups of pulmonary tuberculosis and the organisation of X-ray screening. The initial decrease in the incidence of pulmonary tuberculosis stopped (between 1981 and 1993) and, a minimal increase could be even demonstrated in the last years. The cause of the increase is explained by sociological factors (the influx of refugees, growth in the number of homeless people and of chronic alcoholics). The authors propose the modernization of the preventive and exploratory medical work: the use of computers in the lung-screening center and the institutionalisation of screening aimed at risk groups of pulmonary tuberculosis. In the population over forty years of age 92% of 408 new pulmonary tuberculosis patients, emerged from risk groups between 1981 and 1993, and only 8% from people who did not belong to the risk groups. The effectiveness of screening in the risk groups was 3 to 4 times higher than that of indiscriminate screening.

AIDS-Related Opportunistic Infections↗
PubMed1995

Apolipoprotein E and complement C3 polymorphism and their role in the response to gemfibrozil and low fat low cholesterol therapy.

Three different allelic variants of apolipoprotein E determine, in concert with other gene products, the levels of plasma lipoproteins. Recently, cleavage products of the complement C3 molecule have also been implicated in determining plasma triacylglycerol concentrations. This study presents data of an ongoing study to dissect the role of the apolipoprotein E gene locus in the response to low fat/low cholesterol diet combined with gemfibrozil treatment. In addition, for the first time, the significance of C3 allelic variants to such hypolipidaemic therapy response was analysed. To this end data from 81 obese hyperlipoproteinaemic patients (Fredrickson type II/A and B and type IV and V) confirmed the usefulness of the combined gemfibrozil/diet treatment and unveiled apolipoprotein E allele group specific therapy responses. The mean changes of lipid properties due to combined treatment was 15% for total cholesterol, 48% for triacylglycerols and 28% for atherogenic index. Division into hyperlipidaemia types according to Fredrickson and subgrouping into E2, E3 and E4 groups (apolipoprotein E2/2 and 2/3, apolipoprotein E3/3 and apolipoprotein E4/2 and 4/3 phenotype groups respectively) exposed pronounced differences from these mean changes, suggesting substantial influence of apolipoprotein E variants on this therapy. We observed triacylglycerol reductions of from 17% in type IIA-apolipoprotein E3 group patients up to 78% in the type IV and V-apolipoprotein E2 group. Thus it might be concluded the apolipoprotein E genotyping aides therapy success prediction. Although, low sample number in some subgroups obscures significance in this pilot study, significant therapy success emerges for the E3 and E4 group in type IV and V hyperlipidaemia and type IIB-apolipoprotein E3 homozygous patients can be predicted to respond better than apolipoprotein E2 carriers. Finally, we present evidence that positive changes of lipid properties are also determined by the "fast" complement C3 allel (C3-F). Patients with complement factor C3-FS pattern respond better to treatment than patients with C3-SS configuration. In summary these data endorse the genotyping of apolipoprotein E alleles to predict maximal success of "fibrate" treatment. In addition they argue strongly for further assessment of the involvement of complement C3 allelic variations in lipid homeostasis.

Adult↗
PubMed1994

[Effect of Gevilon therapy and its relation to E polymorphism].

Our clinical trial was set out to estimate the apoE allele frequency by way of polymerase chain reaction and restriction enzyme isoform genotyping amongst 81 obese, hyperlipoproteinemic patients (treated with gemfibrozil + diet). The relative frequencies of the E2, E3, E4 alleles were 0.28, 0.61, 0.11 respectively (according to the Hardy-Weinberg equilibrium). Phenotypes with increased triglycerides levels were dominant in both sexes: IV + V > II/B > II/A (44.4%, 39.5%, 16.0%). Therapy significantly decreased the atherogen lipid values with differing efficacy among each genotype group: E3 > E4 > E2. Our findings demonstrate that in the II/A group there was no great change using the gemfibrozil + diet combination: whereas in IV + V group this combination was effective in each apoE isoform. In the case of II/B it is highly important to determine the apoE genotypes, because the therapy is only efficacious in the E33 group taking all lipid parameters into consideration.

Adult↗
PubMed1993

[Relation of angiographic changes to clinical data and risk factors in patients with arteriosclerosis obliterans].

The arteriographical changes of 66 patients with peripheral arterial obliterative disease and the relationship between the observed alterations and certain clinical and laboratory data as well as some risk factors were analysed. A score system was used to quantify the arteriosclerotic lesions. The arterial alterations of the examined 90 extremities were studied in the pelvic (common and external iliac arteries), femoral (common, superficial, deep femoral and popliteal arteries) and crural (anterior and posterior tibial arteries) regions. Pathomorphological changes in 433 of the investigated 720 arteries were shown, from among them plaque in 11.8%, stenosis in 22.3%, total occlusion in 26% were proved. Most frequently (89%) the superficial femoral artery was affected. As to the single vessels, the superficial femoral and posterior tibial arteries, while among the zones the femoral region proved to be most serious radiologically. The degree and extent of vessel lesions were related to age. The morphological severity was basically concordant with the results of clinical investigations (walking distance, ergometry, Doppler index). The separately examined risk factors (smoking, hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia) were not related consequently to the radiological changes, but in certain combinations, as heavy smoking with hypertension and heavy smoking with diabetes, the relationship proved to be statistically significant.

Adult↗
PubMed1993

[Smoking and mortality: longitudinal epidemiologic study (1975-1991)].

The authors have started a basic screening examination in one of the industrial districts of Budapest in 1975. The district has nearly 100,000 inhabitants. The aim of the examination was to determine the risk factors of lung cancer. 30,566 persons have participated. The health of all patients has been followed up between 1975-1991. During this period 3,573 patients have moved out of the district. On 26,993 patients they have examined the death ratio, the prospective life-span, in the various age groups divided into subgroups according to their smoking habits. They have studied the formation of death rate in the four risk groups determined by them on the basis of the simultaneous examination of more lung cancer risk-factors (risk-free, moderate, high and superhigh risk groups). During these 16 years the death rate both among the heavy smokers and among patients in the high and superhigh risk groups has been two, three, even almost five times higher than that in the non-smoking and in the risk-free group of the relatively younger age groups of the population (born between 1921-1930 and 1931-1938). The knowledge of these connections makes economic calculations possible in respect of life and health insurance.

Adult↗
PubMed1992

Occurrence of oral leukoplakia and lichen planus in diabetes mellitus.

The occurrence of oral leukoplakia and lichen planus in 1600 patients with diabetes mellitus (815 type 1: insulin-dependent, 761 type 2: non-insulin-dependent)-under care at the International Medicine Department-was studied. Precancerous lesions and conditions were diagnosed and grouped according to internationally accepted criteria. The prevalence of oral leukoplakia in diabetic patients was 6.2%, as compared to 2.2% in the healthy controls, that of oral lichen was 1.0% in the test-, and 0.0% in the control group. Leukoplakia and lichen both showed the highest occurrence in the second year of established diabetes, and their prevalence was higher among insulin-treated diabetics. Smokers were more often affected, by both kind of lesions, oral lichen showed a more frequent association with candidiasis. The prevalence of oral leukoplakia and lichen in diabetes mellitus patients was higher, than average ratios in population samples from the same country.

Adolescent↗