Biomedical subjects
Publications and source records attributed to E D Albert.
PGM3 activity was investigated by means of horizontal starch gel electrophoresis. In the pig of the German Landrace three different phenotypes have been recognized: F, S and FS. Family studies suggest the occurrence of at least two alleles--PGM3F and the PGM3S at an autosomal locus.
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Since the estimation of recombination fractions is only an arbitrary means to map genetic loci on chromosomal regions, family studies of cases with informative cross-overs within the region in question are of decisive importance. This paper reports the study of a family with a HLA-B to HLA-D cross-over which is informative in the Bf system. The possible reasons for conflicting published data on Bf gene mapping are discussed.
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The HL-A system is part of the main histocompatibility complex of man which is located on chromosome A6. The clinical importance of this antigen system lies in its application in the immunological choice of donor for transplantations, it being clear that still other important transplantation systems must be located on chromosome 6. The fact that in many diseases certain HL-A antigens occur more frequently has acquired a certain diagnostic significance in ankylosing spondylitis, iritis and juvenile rheumatoid arthritis. The associations with HL-A observed can best be explained by the assumption HL-A-coupled defective immunoresponse genes which are partly responsible for sensitivity to disease.
The polymorphism of the red cell glyoxalase (GLO), which has recently been found to be linked with the major histocompatibility complex (HLA) in man, was investigated in a number of selected families showing various recombinations between HLA-A, HLA-B and the third locus of the phosphoglucomutase (PGM3). In two families with a recombination between HLA-A and HLA-B, the GLO allele travels with the HLA-B locus fragment of the chromosome, indicating that GLO is located on the side of the HLA-B locus. In other families, recombinations occurred between HLA-A and B on one side and GLO and PGM3 on the other side, demonstrating that GLO and PGM3 are located on the same side of HLA. Other recombinations separated PGM3 from GLO so that it can be assumed that GLO is located between HLA-B and PGM3. Thus the immunogenetic linkage group on human chromosome C6 has been increased by yet another outside marker gene to include now the following genes in this order: HLA-A--HLA-C--HLA-B--Bf--HLA-D--GLO--PGM3.
PGM3 activity was investigated in 150 'Boerbok' goats and 132 Angora goats by means of horizontal starch gel electrophoresis. In 'Boerbok' goats no polymorphism was found. In Angora goats three different phenotypes have been recognized: F, S, and FS. The results suggest the occurrence of two common alleles: PGM3-F and PGM3-S at an autosomal locus with frequencies of 0.6176 and 0.3824, respectively.
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