The effects of droperidol and fentanyl on certain parameters of coagulation and fibrinolysis were studied. It was found that these drugs have no effect on the time of clot formation, fibrinogen level, platelet count and values of the thrombelastographic curve. The euglobulin lysis time was also not significantly changed following neuroleptanalgesia.

Adult↗

PubMedDate not supplied

[Continuous intravenous infusion versus intermittent administration of streptokinase in patients with deep venous thrombosis of the lower extremity].

In a multicenter randomized trial, the efficacy and safety of two streptokinase (SK) dosage regimens have been evaluated in patients with proximal deep vein thrombosis of inferior limbs. Twenty-nine patients received SK by a continuous intravenous infusion (250,000 IU as initial dose, 100,000 IU/h as maintenance dose), and 26 patients were treated with intermittent SK administration (500,000 IU as initial dose, followed by 250,000 IU every 12 h). Thrombolytic therapy was continued for 4 days, then the patients received heparin for 5 days and oral anticoagulant for 3 months. The results of treatment as judged by phlebographic examinations were similar in the two groups. Complete, substantial or partial thrombolysis was achieved in 52% of patients in the continuous infusion group and in 58% of patients in the intermittent treatment group. During SK administration, major bleeding complications occurred in 6 patients treated by continuous infusion and in 2 of the second group. The results showed that the intermittent SK administration is as effective and safe as the method of continuous SK infusion in the treatment of deep vein thrombosis.

Adolescent↗

PubMedDate not supplied

[Evaluation of the stability of vincristine binding to blood platelets by the method of spin labeling of platelet membrane].

N-(1-oxyl-2,2,6,6-tetramethylpriperyd-4-y) maleimide (MSL) labels SH or NH2 groups of blood platelets membrane proteins in covalent bonds. Then EPR spectrum of MSL labeled platelets solutions can be measured. Pre-incubation + of the platelets with vincristine prior to MSL labeling induces SH and NK2 groups blocking, decrease in MSL binding to the platelets membrane and EPR spectrum modification of labeled platelets solution. The vincristine effect on platelets membrane lasts until platelets disintegrate. These data confirm, the stability of vincristine bond with platelets membrane.

Blood Platelets↗

PubMedDate not supplied

[Use of vincristine-loaded blood platelets, danazol and gamma globulin in the treatment of patients with idiopathic thrombocytopenic purpura].

In 17 patients with idiopathic thrombocytopenic purpura unresponsive to treatment with steroids, immunosuppression or splenectomy, allogenic vincristine-loaded platelets were used. In 9 of them an increase of platelet number and regression of bleeding tendency was achieved. Among 13 patients with ITP who have been treated with danazol only in one case an increase of platelet number was observed. Under the rise of plasma transaminases and bilirubin level in majority of "danazol" patients we have discontinued the treatment. In none of 4 patients with chronic thrombocytopenic purpura treated with high doses of intravenous immunoglobulin an increase of platelet number was observed, however in all cases the regression of bleeding was achieved.

Adolescent↗

PubMedDate not supplied

Hypoconvertinemia.

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Adolescent↗

PubMedDate not supplied

[Case of hemorrhagic diathesis due to disorders during 1st stage of blood clotting].

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Adult↗

PubMedDate not supplied

[Activation of fibrinolysis in the course of electroconvulsant therapy].

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Anesthesia, General↗