Biomedical subjects
Publications and source records attributed to E Christophers.
The "keratolytic" effect of salicylic acid was examined in guinea-pig skin. Using a fluorescent staining method the str. corneum cells could be seen to rapidly become detached. The cellular walls remained unchanged. This drug therefore appears to primarily reduce the intercellular cohesiveness of the horny cells.
Cell-mediated immune responses in 28 hospitalized patients with psoriasis and in 36 healthy controls were studied using the two-step leukocyte migration agarose test. Specific cell-mediated immunity to A-streptococcal cell wall and cell membrane antigens occurred significantly more often in patients with psoriasis than in the control group. A statistically significant correlation between psoriasis-associated antigens of the HLA-B locus and cellular immune reactivity to A-streptococcal antigens or clinical course was not found. When patients with guttate psoriasis were compared separately with the control group, leukocyte migration inhibition induced by cell-free supernatants of A-streptococcal antigen-exposed mononuclear cell cultures was found to be more frequent than in other forms of psoriasis.
Explore the source record for details and available documents.
A 39 year old woman is reported who has congenital constrictions on several fingers and toes as well as on both lower legs. Ainhum and Ainhum-like syndromes are briefly discussed.
Explore the source record for details and available documents.
Hydrocortisone administered systemically for 3 weeks has no effect on any phase of epidermal cell proliferation as measured by autoradiographic methods. However, the speed of cell differentiation (maturation) is increased, resulting in a thinning of the living epidermis due to the shorter epidermal cell life. Comparison of the epidermis from two body sites (ear and sole of foot) in mice receiving 2.4 mug per gm body weight per day of hydrocortisone in drinking water for 3 weeks revealed no change in the labeling with [3H]thymidine, the mitotic indices, or the lengths of the cell cycle phases. Quantitation of the epidermal cell compartments showed that thinning of the epidermis with hydrocortisone was due to the loss of an identical number of differentiating epidermal cells per unit surface from both body sites. In both sites there was the same increased rate of maturation of postmitotic cells while the proliferative cell-pool remained unresponsive to the hormone. The alteration of the speed of cell maturation is the principal action of hydrocortisone in epidermis. The results indicate that the epidermal cellular concentration of, and the susceptibility to, the hormone were identical in ear and sole of foot despite the differing speeds of turnover of the two tissues.
Explore the source record for details and available documents.
Delayed skin reaction to tuberculin were elicited in 10 healthy persons by patch testing and intracutaneous application of the antigen (Tine-Test). Biopsies revealed basically identical tissue reactions. After intracutaneous injection of the antigen as well as after Tine-testing the changes were solely found in the dermis, while after patch testing dermal and epidermal alterations were prominent. The type of response elicited by the same allergen in man-the so called tuberculin type of the eczematous type-therefore are due to a differential localization of the antigen.
Explore the source record for details and available documents.
In two patients (mother and daughter subungual pterygia were seen on the fingers of both hands. The abnormalities were congenital and painful. A disproportional extension of the nail bed epithelium with dislocation of the hyponychiuum is the suggested cause of this entity. No useful therapy was found.
Comedo-like follicular papules of hair-follicles, confined to the left side of the upper part of the body, were found in a 22-year-old woman. Histological features were of epidermolytic hyperkeratosis with involvement of the follicular epithelium and the sebaceous duct with compact hyperkeratosis, but almost no interfollicular epidermal alterations were found. Because of the nevoid distribution, the prominent follicular plugging, and epidermolytic hyperkeratosis, we describe this condition as nevoid follicular epidermolytic hyperkeratosis.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.