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Biomedical subjects

E Chihara

Publications and source records attributed to E Chihara.

84 records · Page 5Linked to original sources
PubMed1979

Axoplasmic transport blockage therapy in herpes zoster ophthalmicus.

Three patients with herpes zoster ophthalmicus were treated with an oral administration of colchicine and corticosteroid, while another seven were given systemic corticosteroid, vitamins, and sedatives. Colchicine inhibited the formation of new skin lesions but did not suppress the already grown vesicles. The effect of colchicine was attributed to a blockage of intra-axonal dissemination by neurotrophic virus.

Adrenal Cortex Hormones↗
PubMed1979

Treatment of Mooren's ulcer by conjunctival excision.

3 early Mooren's ulcers were successfully treated by only one-time conjunctival excision adjacent to the ulcer, while in 2 other chronic vascularized Mooren's ulcers, repeated conjunctival excision was required for a final remission. The clinical outcome of these 5 eyes was better than that of 7 other eyes treated by conjunctival flap procedure, lamellar keratoplasty, topical eye drops or systemic medications. Four fragments of excised conjunctival tissue were examined histopathologically; the substantia propria was found to be infiltrated with plasma cells.

Adult↗
PubMed1979

Axoplasmic and nonaxoplasmic transport along the optic pathway of albino rabbits; a theoretical pattern of distribution.

Distribution of nonaxoplasmically transported material along the optic pathway of the rabbit was studied after blockage of the axonal flow by vinblastine, and a clear pattern of distribution of the axoplasmic transport was deduced by subtraction from the pattern seen in nontreated animals. Vascular participation in the nonaxoplasmic transport was certified by autoradiographic studies. The theoretical pattern of distribution of axoplasmic transport in the optic system under ideal conditions was calculated from an idealized model system. From the comparison of theoretical and experimental patterns, partial obstruction of the axonal flow likely occurs at the optic foramen and chiasma.

Animals↗
PubMedDate not supplied

Detection of a new TIGR gene mutation in a Japanese family with primary open angle glaucoma.

PURPOSE: To describe a new mutation of the trabecular meshwork-inducible glucocorticoid response protein (TIGR) gene in a Japanese patient with familial primary open angle glaucoma (POAG). METHODS: Standard ocular examinations were performed on the 44-year-old patient, his sister, and mother. DNA sequencing was used to identify the mutation. We also developed a DNA diagnostic method for detecting this missense mutation by polymerase chain reaction-induced mutation restriction analysis (PCR-IMRA). RESULTS: The patient, father, and sister had been diagnosed as having POAG. The patient and his sister had a Thr448Pro mutation (C-->A transition at the nucleotide number 1419) in exon 3. This mutation has not been reported before. CONCLUSIONS: Gene analysis is promising for an early diagnosis among the family members of familial POAG patients and will contribute to early therapy before an occurrence of irreversible visual impairment.

Aged↗
PubMedDate not supplied

Optical coherence tomography images of retinitis pigmentosa.

The retinas of 3 patients with typical retinitis pigmentosa (RP) were evaluated by optical coherence tomography (OCT), fluorescein angiography (FA), and fundus photography (FP). OCT showed that retinal thickness was decreased in the areas of the retina affected by RP, and nearly normal in the unaffected macular area. Reflectivity was partially decreased in the affected retinal areas and pigment masses were hyper-reflective. Reflectivity of the macular area was nearly normal except in the fovea, where it was decreased because of edema. Cystic spaces of the fovea were evident in Patient 1.

Aged↗