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Biomedical subjects

E C Anderson

Publications and source records attributed to E C Anderson.

82 records · Page 5Linked to original sources
PubMed1966

Life cycle analysis of mammalian cells. 3. The inhibition of division in Chinese hamster cells by puromycin and actinomycin.

Analysis of the effects of actinomycin and puromycin on the G(2) and mitotic parts of the life cycle in Chinese hamster ovary cells grown in suspension and synchronized by thymidine treatment has been carried out. Rates of division of partially synchronized cell populations were measured in the presence and absence of the drugs, and various controls were performed to test for absence of complex side effects. Actinomycin produces a block 1.9 hr before completion of division, while puromycin produces a block almost coinciding with the initiation of mitosis. Evidence is presented that the puromycin block may be a double one, inhibiting one kind of protein synthesis that virtually coincides with the beginning of mitosis and another that occurs about 8 min earlier. The data are interpreted in terms of the time interval between messenger formation and its associated protein synthesis in this region of the life cycle. The various events studied have been provisionally mapped in the G(2) and mitotic periods of the life cycle.

Animals↗
PubMedDate not supplied

Vertebral artery trauma: transcatheter embolization.

Injuries of the vertebral arteries in four patients were treated by transcatheter embolization. Embolotherapy was performed after incomplete or unsuccessful surgery in three of the patients and as a preventive measure in lieu of surgery in the fourth patient. All procedures were successful and without complications. An injured vertebral artery is usually extremely difficult to approach surgically, but because of extensive collateral blood supply it is usually expendable; therefore, it becomes an inviting target for management by interventional angiographic techniques. Embolotherapy of an injured vertebral artery is easier, faster, and safer than its surgical ligation and, therefore, decidedly superior. With few exceptions, embolotherapy should be considered the preferred method in the management of vertebral artery trauma.

Adult↗