[Primary breast osteosarcoma].
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Breast Neoplasms↗
Biomedical subjects
E Burgos
Publications and source records attributed to E Burgos.
[Jaundice due to an oxyphenisatin laxative].
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Adult↗
Ruptured primary splenic angiosarcoma into the colon. Presentation as anal bleeding.
A 71-year-old woman presented with a six month history of constipation and abdominal discomfort, with anal bleeding during the last days. Ultrasonography and CT-scan of the abdomen showed a large heterogeneous mass that was located in the splenic region, but the nature and origin of the tumour could not be clearly established preoperatively. The clinical diagnosis was of abdominal tumour with colonic and splenic involvement, and a left hemicolectomy and splenectomy were performed. Pathologic examination revealed a primary angiosarcoma of the spleen with penetration and fistulization of the tumour into the large bowel. The patient received adjuvant radiation therapy, but she died of extensive metastastic disease from her primary angiosarcoma of the spleen nine months after surgery. In summary, splenic angiosarcoma is very difficult to diagnose preoperatively. This highly aggressive neoplasm has an overall poor prognosis, specially if it is associated with rupture and haemoperitoneum. As this case highlights, unusual forms of rupture may lead to atypical clinical presentations, increasing even more the difficulty in the diagnosis.
Aged↗
[Intra-diverticular adenocarcinoma of the urethra in women].
We report on a female patient who presented with urethrorrhagia and a palpable urethral mass which was diagnosed as urethral diverticulum, the site of a tumor that proved to be adenocarcinoma of the urethra. The patient underwent radical urethrectomy and pelvic and inguinal lymphadenectomy. Urethral reconstruction was performed using a vesical flap following the technique described by Tanagho. Thereafter, she received 6 courses of M-VAC polychemotherapy. Diverticulum and carcinoma of the female urethra are uncommon. Adenocarcinoma is the most common tumor type encountered in these diverticula. Diagnosis is clinically simple and treatment is by radical surgery and radiotherapy. The foregoing treatment modalities have improved patient survival when the tumor is detected early. This tumor type is particularly aggressive and outcome depends on tumor stage.
Adenocarcinoma↗
[Paraganglioma of the cauda equina with gangliocyte differentiation].
Clinicoradiologic and pathologic data of a patient with a paraganglioma of the cauda equina are described. The peculiar aspect of this rare case is the gangliocyte differentiation with mature ganglion cells scattered in the tumor. The histologic and ultrastructural features are similar to other described cases of this tumor, with Zellballen pattern and neurosecretory granules. The immunohistochemical studies are quite typical with positive staining with neuroendocrine markers (N.S.E., G.F.A.P.). An interpretation of these findings is made.
Adult↗
Transformed mesothelial cells in patients on CAPD for medium- to long-term periods.
OBJECTIVE: To describe the characteristics of abnormal cells present in the peritoneal effluent of 4 continuous ambulatory peritoneal dialysis (CAPD) patients; the cells were accidentally detected in a longitudinal study of cell populations in 83 patients. DESIGN: Descriptive study. PARTICIPANTS: Four stable CAPD patients (2 male, 2 female). INTERVENTIONS: Peritoneal cells were collected from nocturnal peritoneal effluent (NPE) by centrifugation. MEASUREMENTS: Light microscopy, ultrastructural, cytochemical, and immunohistochemical characteristics were studied. RESULTS: The abnormal cells were characterized by a flat appearance, large size (diameter 100 microns)--six to ten times larger than a normal macrophage, a broad acidophilic cytoplasm with rare granulations, and a low nucleus/cytoplasm ratio. The nucleus was pyknotic, with dense chromatin and sometimes appeared fragmented. Its number presented a considerable variability between the patients and was much higher in the 2 females. This number remained stable in each patient over time. These cells were negative for beta-glucuronidase and positive for PAS stain with variable intensity. A very low number of flat cells were positive for vimentin with weak intensity, whereas cytokeratin and epithelial membrane antigen (EMA) were positive in a higher number of cells with medium to strong intensity. Ultrastructural studies showed numerous short surface microvilli, cytoplasm well-developed with intracytoplasmic lumina and abundant, dispersed intermediate filaments, scattered mitochondria, and stacks of rough endoplasmic reticulum were observed. Dispersed secretory vacuoles and isolated lipid vacuoles were present. CONCLUSION: All these features imply that they are mesothelial in origin and are suggestive of a change known as peritoneal squamous metaplasia. To date, the clinical follow-up of our patients has shown a benign outcome; further studies are necessary to elucidate the significance of this peritoneal squamous metaplasia in CAPD patients.
Adult↗