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Biomedical subjects

E Brug

Publications and source records attributed to E Brug.

84 records · Page 5Linked to original sources
PubMed1975

[A case of endogenous familial hereditary malformation of both hands].

A case of congenital malformation of both hands in a 22 year old television-technician, who otherwise showed no abnormalities, is reported. In his case, a familiar incidence was observed constantly in all males for a period of nearly 200 years. The morphological picture of this malformation is as follows: left hand: postaxial oligodactyly with a cutaneous syndactyly of the third and fourth fingers accompanied by a V-shaped os metacarpale and a synostosis of the os triquetrum, os lunatum and possibly of the os pisiforme right hand: postaxial oligodactyly with an accessory hypoplastic third finger on the ulnar side with a common base of the proximal phalanx which was enlarged at the end and shorter than the others (symbrachybasophalanx). Os multangulum minus and os capitatum as well as os triquetrum and possibly also the os pisiforme showed a synostosis. Subjective symptomatology and further clinical investigations (Phonocardiogramm) revealed an associated heart disease. This kind of malformation of both hands is transmitted inclompletely only in males.

Abnormalities, Multiple↗
PubMedDate not supplied

[Enchondroma of the hand].

Enchondromata are the most frequent benign tumours of the bones of the hand. From 1973 to 1990 77 patients were treated at the trauma- and hand surgery department of the Westfälische Wilhelms-University in Münster because of a histologically confirmed enchondroma. Those 52 patients (32 female, 20 male, average age 32 years), who were operated on until 1986 were reviewed. After an average history of 16 months the diagnosis was made most often because of a painful swelling. In 15% a spontaneous fracture was seen and in 17% the enchondroma was diagnosed by chance. The enchondroma was merely exstirpated or in other cases the defect was filled with a bone graft. The follow-up with a maximal time of 14 years postoperatively yielded in 81.6% an excellent and good result. A 5.7% (3 pat.) recurrence rate was observed and was attributed to an incomplete resection of the underlying pathology. Follow up X-rays are therefore recommended.

Adolescent↗
PubMedDate not supplied

[Congenital windblown hand position of the fingers].

The wind-blown hand is part of a complex congenital malformation syndrome. In addition to malformations in the head and feet, the hands are deformed in a characteristic manner. The metacarpophalangeal joints are bilaterally in flexion contracture and ulnar deviation. The thumb is adducted (thumb-in-palm deformity), flexed in the metacarpophalangeal joint and hyperextended in the interphalangeal joint. The etiology of this rare congenital syndrome is relatively unknown, although some hypotheses are discussed. Conservative therapeutic procedures include early splinting, but results are often disappointing. Early performed operations may improve hand function.

Contracture↗
PubMedDate not supplied

Penetration of ciprofloxacin into bone: a new bioabsorbable implant.

The implantation of antibiotic-containing cement beads became standard adjuvant local antibiotic therapy of chronic osteomyelitis. The new developed bioabsorbable drug carrier system of polyglycolic acid with the antibiotic Ciprofloxacin was tested in vitro and in vivo. The goal of this study was to determinate the penetration depth of Ciprofloxacin into bone cortex and marrow. Two monofil, PGA cylinders, 3.2 x 5 mm in size, containing 3 mg of Ciprofloxacin each, were implanted into the proximal part of both femora of 18 rabbits (New Zealand white). After sacrifice, the concentration of Ciprofloxacin in micrograms/g cortex and marrow was measured with high-performance liquid chromatography in relation to the distance from the test material at day 2, as well as at 1, 2, 3, 4, and 6 weeks postimplantation. For a distance up to 5 mm, marrow levels of the drug exceeded cortical levels at day 2 (5000 to 240 micrograms/g). At a distance of 5-10 mm, cortex levels were similar to marrow levels after 2 weeks and were higher than marrow levels at week 3. This observation could be made at a distance between 10 and 15 mm only after 2 days. Later, marrow concentrations again exceeded that in cortex. At a distance of more than 15 mm, antibiotic levels were low and approximated. After 6 weeks, at 5 mm distance, a bactericidal drug concentration of about 2 micrograms/g in bone marrow could be measured. Drug penetration into cortical bone in bactericidal concentrations of about 2 micrograms/g was achieved at up to 30 mm in the first few days.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗