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Biomedical subjects

E Biemer

Publications and source records attributed to E Biemer.

At least 91 records · Page 5Linked to original sources

[Corrective interventions of the breast].

The shape, size and location of the nipple and areola are the points that distinguish and ideal-looking breast. Tuberous deformity, inverted nipple and excess of areola tissue are congenital anomalies of the breast. Surgical correction is indicated especially in a case of asymmetry. Acquired malformations of the nipple-areola complex can be the result of injuries or surgical treatment like breast reduction. In this cases a surgical correction improves the result. Some representative cases are demonstrated.

Breast↗

[Free tissue transfer].

The free flap transfer has his place in situations were regional flaps--especially pedicled muscle flaps--are not available. This is especially true for the medial and distal third of the lower limb. Another important indication is in infected situations, where we can put the muscle, for example from the free myocutaneous flaps in the infected bone area. At the sole of the foot and the heel we see a special indication, because we can restore by the free tissue transfer sensibility. This means in our opinion a good precaution for reulceration. By the use of a two-team approach the primary long operation time could be cut down up to two to four hours. By simplifying the whole procedure we also could achieve a high success rate of 93.5% in 345 cases which we operated since 1974. In the last two years we did not have any necroses in 94 cases. Therefore we think that nowadays the indication for free flap transfer in the soft tissue reconstruction at the lower extremity and the foot has to be widened.

Debridement↗

[A new technic of nipple reconstruction].

Many methods of reconstruction of the nipple have been described in the last few years, but none are completely satisfactory. The main objectives are reconstruction, size, forward projection of the nipple, and pigmentation of the areola comparable to the other side. The combination of a local dermal flap and a full-thickness skin graft from the inner thigh provides a solution to the problem while avoiding any interference with the opposite nipple.

Breast↗

[Plastic-surgical therapy of extensive radiogenic recurrence of pharyngo-esophagostoma].

Reconstruction of extended post-irradiation pharyngo-esophagostomy is still a formidable challenge in head and neck surgery. Early rehabilitation of speech, swallowing and chewing and prevention of severe hemorrhage of the carotid artery by soft tissue coverage is mandatory. If previous attempts with local lipocutaneous and myocutaneous flaps have failed, a two stage reconstruction by microsurgical transfer of a jejunal patch in combination with a myocutaneous latissimus dorsi flap will lead to sufficient lining and a permanent closure of the defect. The indication and the technical procedures in two clinical cases following multiple recurrences of pharyngo-esophagostomy due to irradiation damage of the neck are discussed.

Adult↗

Insulin receptor kinase in human skeletal muscle.

Receptor-associated protein kinase activity has been shown in all primary target tissues of insulin action in the rat and a function of insulin receptor phosphorylation in signal transmission was proposed. Insulin receptor phosphorylation so far has not been demonstrated in human target tissues of insulin. We describe here insulin receptor kinase activity in human skeletal muscle. Insulin (10(-8) mol/l) stimulates the phosphorylation of a 95-kDa protein from skeletal muscle 2-fold. The phosphoprotein is quantitatively immunoprecipitated with insulin receptor antibody identifying it as the beta-subunit of the insulin receptor. The insulin stimulation of phosphorylation is detectable also at physiological insulin concentrations (10(-9) mol/l) showing that receptor phosphorylation could be involved in insulin action in human skeletal muscle as well.

Animals↗

[Possibilities of the covering of scalp defects after injury or tumor resection].

The coverage of extensive defects of the scalp is sometimes a problem. In some clinical cases the methods of definitive coverage are shown. Microsurgery permits the replantation of a scalp or the coverage of a defect with a free flap. A new technique consists in the use of a tissue expander to stretch the remaining scalp.

Female↗

Viability of surrounding tissue attached to vein graft.

The technique of grafting skin with an attached subcutaneous vein for vessel-skin defects was investigated in an experimental rabbit study. Vein grafts were not able to nourish the skin immediately after grafting. After 14 days, there was a certain amount of vital, revascularized tissue in the area of the vein graft. Plasmatic circulation and revascularization from the wound bed are apparently responsible for the successful clinical application of this technique.

Angiography↗

[Sensory transplants of the sole of the foot].

The covering of defects of the sole of the foot and the heel with pedicled and free neurovascular flaps such as the dorsalis pedis flap, the forearm flap and the pulp neurovascular flap shows good success because of early pain sensation re-ulceration can be prevented. Clinical cases are demonstrated.

Amputation, Traumatic↗

[Forearm flap with its various possibilities of application].

The authors describe the different possibilities of the forearm flap as a free and pedicle flap. The forearm flap is arterialized by the A. radialis, the venous outflow goes through the Venae comitantes of the A. radialis or the big veins of the forearm (V. cephalica and basilica). Sensation can be preserved through the three cutaneous forearm nerves. The advantage of the flap is based on the constant anatomy, the big vessels and nerves, the quality and quantity of the forearm skin as well as the relatively thin layer of subcutaneous fat.

Arteries↗

[Should a single long finger be replanted?].

The indications for the replantation of single amputated digits are still widely discussed. According to our experience of 136 replanted single fingers in a period of six years and the results of an examination of 86 of these cases carried out subsequently, a large percentage of the patients is satisfied with the outcome of their operations. Therefore in general replantation of single fingers should not be rejected. In a doubtful case it would be advisable to transfer the patient to a hand- and microsurgery center.

Amputation, Traumatic↗