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Biomedical subjects

E Adam

Publications and source records attributed to E Adam.

At least 163 records · Page 9Linked to original sources
PubMed1980

Urinary tract changes associated with exposure in utero to diethylstilbestrol.

Intravenous pyelograms were performed on 128 women who had been exposed in utero to diethylstilbestrol (DES). For comparison, intravenous pyelograms (IVPs) of 48 non-exposed women were reviewed: No difference in urinary tract abnormalities was noted. There was no significant increase in urinary tract abnormalities in women with upper genital tract abnormalities demonstrated by hysterosalpingogram as compared to a group of women whose x-rays of the uterus were normal.

Abnormalities, Drug-Induced↗
PubMed1979

The culture of tissue from the ovary of the goldfish Carassius auratus.

Small pieces of ovarian tissue derived from immature goldfish have been maintained in culture periods of up to three months. The progress of the culture was monitored by light and electron microscopy and showed that although degenerative changes occurred in the large oocytes the small oocytes and oogonia survived for the duration of the culture. Quantitative studies indicate that both oogonia and small oocytes increase in number during the first three weeks of culture and observations from experiments using 3H-thymidine support the idea that a limited proliferation can occur using the relatively simple technique described.

Animals↗
PubMed1979

Cervical cancer cell lines containing herpesvirus markers.

Five epithelioid cell lines were established from invasive cervical carcinoma tissue and were examined for herpes simplex virus (HSV) antigens or virus-induced changes. Immunofluorescence studies with antiserum to an HSV type 2 nonstructural polypeptide detected perinuclear antigens. In these cell lines, concentrations of a membrane fucopeptide that is regularly present in normal cells were reduced to levels similar to those previously observed in virus-transformed cells. One of the cell lines inoculated into athymic mice produced tumors.

Animals↗
PubMed1979

Detection of herpesvirus type-specific antibody by a micro solid phase radioimmunometric assay.

A micro solid phase radioimmunometric assay has been developed which measures type-specific antibody in human sera to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The test is performed by coating wells of microtiter plates with purified HSV-specified glycoproteins, VP123 and VP119, derived from HSV-1- and HSV-2-infected cells, respectively. The coated wells are then incubated with diluted unadsorbed sera and subsequently with radioiodinated goat anti-human IgG reagent. Because these major viral envelope glycoproteins contain type-specific antigenic determinants, type-specific antibodies are preferentially detected in our assay.

Antibodies, Viral↗
PubMed1979

Persistence of virus shedding in asymptomatic women after recovery from herpes genitalis.

One hundred seventeen women were reexamined within 6 months after presenting with genital herpes. Swabs for virus isolation were taken from the cervix whether or not lesions were observed. Herpesvirus type II was isolated from 30 of 67 patients with recurrent disease, but also from 5 of 50 women during periods when there were no signs or symptoms of illness. The epidemiologic importance of virus shedding from asymptomatic women is discussed.

Adult↗
PubMed1978

Treatment of genital herpes simplex virus infection with photodynamic inactivation.

A double-blind randomized study to evaluate the effect of proflavine in the treatment of genital herpesvirus infection was conducted. One hundred fifty-seven women were studied, of whom 75 were treated with proflavine (treated women) and 82 were treated with placebo (control group). There were 62 women with primary disease and 95 with recurrent infection. Under the conditions by which this study was conducted, there was no apparent difference in the time of healing of lesions, development of recurrences, or virus isolation following treatment in the proflavine-treated and control groups.

Acridines↗
PubMed1978

Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project.

The National Cooperative Diethylstilbestrol Adenosis (DESAD) Project has completed the major portion of its enrollment phase with the examination of more than 3000 daughters of women taking synthetic nonsteroidal estrogens (denoted DES) during pregnancies occurring from the early 1940s to the mid-1960s. The aims of the Project are to fill urgent needs for information on the prevalence and incidence of structural and epithelial abnormalities or neoplastic changes and their complications in these young women. Participants are grouped by mode of entry as identified by prenatal record review (40.1%), documented as DES-exposed but walking in (25.1%), or referred (22.8%) to the DESAD Project for examination, and not documented as exposed but having gynecologic abnormalities typical of those associated with DES exposure (12.0%). This study cohort, in part having paired controls, will be examined annually for at least 5 years. Details of the design and selected preliminary findings are reported.

Adolescent↗
PubMed1978

Association of cytomegalovirus (CMV) infection with cervical cancer: isolation of CMV from cell cultures derived from cervical biopsy.

Cytomegalovirus (CMV) was isolated from cell cultures derived from 2 of 10 cervical cancer biopsies from patients in an advanced stage of the disease. Five serial passages were necessary before extensive cytopathic changes characteristic of CMV infection appeared. All patients tested had complement-fixing antibodies to both isolates in higher titers than to the prototype AD169 strain. 6 of 8 patients tested also had herpesvirus type 2 antibodies.

Adult↗
PubMed1978

Genital tract anomalies associated with in utero exposure to diethylstilbestrol.

The gross anatomic changes and the vaginal epithelial changes in 687 women exposed in utero to diethylstibestrol are described, as well as the findings in 66 of these women who agreed to undergo hysterosalpingography. Of 537 women in the study group whose time of in utero exposure to stilbestrol was known. 33% demonstrated gross anatomic changes of the cervix, whereas 44% of them were found on colposcopic examination to have vaginal epithelial changes. These changes occurred in a significantly higher percentage of women exposed in utero before the 20th week of gestation. Among the women included in the study on the basis of a review of their prenatal history, gross anatomic changes of the cervix seemed to be more common in those under the age of 19 years than in those older than 19 when they first entered the study. Gross abnormalities in the uterus were noted in 44 of the 66 women studied by hysterosalpingography. These changes consisted primarily of marked aberrations in the size and shape of the uterine cavity.

Adolescent↗
PubMed1977

Upper genital tract changes associated with exposure in utero to diethylstilbestrol.

Hysterosalpingograms of 60 young women exposed in utero to diethystilbestrol were obtained. In 46 instances, documentation of this exposure was obtained from the mother's chart review or confirmed by the attending physician. In 14 instances, the patients' mothers were sure they had received stilbestrol, but documentation could not be specifically confirmed. Hysterosalpingograms of 23 women being investigated for infertility during the same period that the current study was conducted were also reviewed. In 40 women exposed to stilbestrol, changes in the uterus which differed significantly from those seen in the past in nonexposed individuals were noted. These changes consisted of a 'T-shaped appearance of the uterus,' constricting bands in the uterine cavity, a hypoplastic uterus, and less frequently, intrauterine polypoid defects, synechiae, and in one instance a unicornuate uterus. In 36 of the 40 women gross defects were also noted in the cervix. By comparison, in none of the control subjects were defects noted which could be considered comparable with those seen in the DES-exposed patient.

Adolescent↗
PubMed1977

[Simultaneous measurement of cardiac output by indium 113 m detected externally and by dye dilution of indocyanine green].

The cardiac output of 11 patients was measured by a method of dilution of a short-life radio-isotope, and compared with measurements obtained simultaneously by a dye dilution technique. After sudden intravenous injection of siderophilin (transferrin) labelled by Indium 113 m, the precoridal radioactivity was measured by a single panel detector probe. In 9 patients these measurements were carried out twice with a 15 minute interval. The correlation coefficient between the two methods was 0.884 for 20 measurements, and 0.939 for the first 11 measurements. The reproducibility of these measurements was comparable for the two techniques. The radio-isotope method of measuring cardiac output, which can be carried out at the bedside, is a simple, reliable and reproducible technique.

Cardiac Output↗