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Biomedical subjects

E A Walker

Publications and source records attributed to E A Walker.

At least 91 records · Page 5Linked to original sources
PubMed1990

Psychiatric illness and irritable bowel syndrome: a comparison with inflammatory bowel disease.

Structured psychiatric interviews and psychological self-report measures were administered to 28 patients with irritable bowel syndrome and 19 patients with inflammatory bowel disease. Significantly more of the patients with irritable bowel syndrome had lifetime diagnoses of major depression, somatization disorder, generalized anxiety disorder, panic disorder, and phobic disorder. They had significantly more medically unexplained somatic symptoms, and most had suffered from psychiatric disorders, particularly anxiety disorders, before the onset of their irritable bowel symptoms.

Adult↗
PubMed1990

Irritable bowel syndrome and psychiatric illness.

Psychiatric illnesses such as mood, anxiety, and somatization disorders share many common features with irritable bowel syndrome. The authors review recent developments in the definition of irritable bowel syndrome and its relationship to psychiatric illness, discuss the diagnostic validity of irritable bowel syndrome from several perspectives, and offer a pathophysiological model of irritable bowel syndrome that integrates many of the biological and psychosocial findings of earlier studies. Psychiatric evaluation appears to be an important factor in the diagnosis and treatment of patients with irritable bowel syndrome.

Colonic Diseases, Functional↗
PubMed1990

Guillain-Barré syndrome and pan-uveitis.

A case history of a patient diagnosed as having Guillain-Barré syndrome who is also found to have a pan-uveitis which has caused significant deterioration in vision and which has been slow to resolve on treatment. This would appear to be the first such report in the literature.

Aged↗
PubMed1985

The effect of oxygen concentration on the teratogenicity of salicylate, niridazole, cyclophosphamide, and phosphoramide mustard in rat embryos in vitro.

Comparisons were made of rat embryos cultured at 5% or 20% oxygen in the presence of salicylate (SAL), cyclophosphamide (CP), niridazole (NDZ), or phosphoramide mustard (PM). Multiple regression analyses were used to compare the effects of drug concentration, oxygen concentration, and the product of drug times oxygen concentration on malformation incidence, viability, and protein content of embryos cultured for 24 hours. Drug concentration significantly affected malformation incidence or severity and protein content (P less than 0.001) for the four drugs tested. Oxygen concentration significantly affected protein content for the four compounds (P less than 0.001) but affected malformation incidence only with NDZ. Furthermore, the interaction of oxygen concentration and drug concentration significantly affected the malformation incidence in the presence of NDZ (P less than 0.001), and protein content (P less than 0.001) and viability (P less than 0.001) in the presence of CP. The pattern of significant effects of the independent variables (drug concentration, oxygen concentration, and drug times oxygen concentration) is consistent with the hypotheses of oxygen-dependent metabolism (or lack of metabolism) of the drugs in question. NDZ, which is thought to be converted to reactive intermediates by an oxygen-inhibited nitroreductase, was more toxic at reduced oxygen tension. CP, which is activated by an oxygen-dependent P-450 system, was more toxic with increased oxygen tension. Significant effects of the independent variables on embryos exposed to SAL or PM were consistent with the effects on control embryos, notably, increased protein content with increased oxygen.

Abnormalities, Drug-Induced↗
PubMed1982

Primary syphilis of the tonsil.

A 42-year-old patient with an ulcerative left tonsil that was not particularly painful was examined. The routine blood test for syphilis was reactive. The patient was found to have a chancre of the left tonsil. Painless ulcers of the left tonsil in a sexually active individual should be considered as possibly syphilitic.

Adult↗
PubMed1980

[Research on the etiological factors of oesophageal cancer in the West of France (author's transl)].

There is strong epidemiological evidence that oesophageal cancer in the West of France is related to alcohol consumption. Various laboratory studies have been undertaken in connection with this finding. Samples of the spectrum of alcoholic drinks consumed in the region, notably apple cider and its distillates, were collected from retail outlets and from farms: several distillates produced under experimental conditions in the laboratory were also examined. These samples were analysed for the presence of selected nitrosamines; small amounts were found for the most part in beer, which is little consumed in Normandy and Brittany. Mutageniticy tests on the apple cider based drinks and on other commercially available alcoholic beverages (beer excepted), have shown a weak response, for the most part in farm distillates, that can be attributed neither to nitrosamines nor to polycyclic aromatic hydrocarbons, but to some other as yet unidentified compounds.

Alcoholic Beverages↗
PubMed1980

International mycotoxin check sample program. Part I. Report on the performance of participating laboratories.

Three aflatoxin-contaminated samples, raw peanut meal, finished peanut butter, and white corn meal, were analyzed by 139 laboratories in 34 countries. Sufficient data were obtained to permit a statistical comparison of the performance of laboratories using the BF, CB, and Pons methods and those using high performance liquid chromatography for quantification. A raw peanut meal sample showed no significant differences among means for laboratories using the four methods, and a white corn meal sample showed only one such significant difference; however, a finished peanut butter sample containing less than 10 micrograms total aflatoxins/kg showed 10 significant differences among means for laboratories using the 4 methods considered.

Aflatoxins↗