Search PubMed⌕ Search

Biomedical subjects

Derek Abbott

Publications and source records attributed to Derek Abbott.

5 recordsLinked to original sources

Towards functional 3D T-ray imaging.

We review the recent development of T-ray computed tomography, a terahertz imaging technique that allows the reconstruction of the three-dimensional refractive index profile of weakly scattering objects. Terahertz pulse imaging is used to obtain images of the target at multiple projection angles and the filtered backprojection algorithm enables the reconstruction of the object's frequency-dependent refractive index. The application of this technique to a biological bone sample and a plastic test structure is demonstrated. The structure of each target is accurately resolved and the frequency-dependent refractive index is determined. The frequency-dependent information may potentially be used to extract functional information from the target, to uniquely identify different materials or to diagnose medical conditions.

Algorithms↗

Label-free bioaffinity detection using terahertz technology.

We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 microg cm(-2) of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.

Affinity Labels↗

Brownian ratchets and Parrondo's games.

Parrondo's games present an apparently paradoxical situation where individually losing games can be combined to win. In this article we analyze the case of two coin tossing games. Game B is played with two biased coins and has state-dependent rules based on the player's current capital. Game B can exhibit detailed balance or even negative drift (i.e., loss), depending on the chosen parameters. Game A is played with a single biased coin that produces a loss or negative drift in capital. However, a winning expectation is achieved by randomly mixing A and B. One possible interpretation pictures game A as a source of "noise" that is rectified by game B to produce overall positive drift-as in a Brownian ratchet. Game B has a state-dependent rule that favors a losing coin, but when this state dependence is broken up by the noise introduced by game A, a winning coin is favored. In this article we find the parameter space in which the paradoxical effect occurs and carry out a winning rate analysis. The significance of Parrondo's games is that they are physically motivated and were originally derived by considering a Brownian ratchet-the combination of the games can be therefore considered as a discrete-time Brownian ratchet. We postulate the use of games of this type as a toy model for a number of physical and biological processes and raise a number of open questions for future research. (c) 2001 American Institute of Physics.

Journal Article↗

Control systems with stochastic feedback.

In this paper we use the analogy of Parrondo's games to design a second order switched mode circuit which is unstable in either mode but is stable when switched. We do not require any sophisticated control law. The circuit is stable, even if it is switched at random. We use a stochastic form of Lyapunov's second method to prove that the randomly switched system is stable with probability of one. Simulations show that the solution to the randomly switched system is very similar to the analytic solution for the time-averaged system. This is consistent with the standard techniques for switched state-space systems with periodic switching. We perform state-space simulations of our system, with a randomized discrete-time switching policy. We also examine the case where the control variable, the loop gain, is a continuous Gaussian random variable. This gives rise to a matrix stochastic differential equation (SDE). We know that, for a one-dimensional SDE, the difference between solution for the time averaged system and any given sample path for the SDE will be an appropriately scaled and conditioned version of Brownian motion. The simulations show that this is approximately true for the matrix SDE. We examine some numerical solutions to the matrix SDE in the time and frequency domains, for the case where the noise power is very small. We also perform some simulations, without analysis, for the same system with large amounts of noise. In this case, the solution is significantly shifted away from the solution for the time-averaged system. The Brownian motion terms dominate all other aspects of the solution. This gives rise to very erratic and "bursty" behavior. The stored energy in the system takes the form a logarithmic random walk. The simulations of our curious circuit suggest that it is possible to implement a control algorithm that actively uses noise, although too much noise eventually makes the system unusable. (c) 2001 American Institute of Physics.

Journal Article↗

Overview: Unsolved problems of noise and fluctuations.

Noise and fluctuations are at the seat of all physical phenomena. It is well known that, in linear systems, noise plays a destructive role. However, an emerging paradigm for nonlinear systems is that noise can play a constructive role-in some cases information transfer can be optimized at nonzero noise levels. Another use of noise is that its measured characteristics can tell us useful information about the system itself. Problems associated with fluctuations have been studied since 1826 and this Focus Issue brings together a collection of articles that highlight some of the emerging hot unsolved noise problems to point the way for future research. (c) 2001 American Institute of Physics.

Journal Article↗