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Biomedical subjects

Dariusz Jurkiewicz

Publications and source records attributed to Dariusz Jurkiewicz.

At least 37 records · Page 2Linked to original sources
PubMed2005

[Immunoregulatory disorders in chronic sinusitis in patients with atopy].

UNLABELLED: Disorders of immunoregulatory activity of T lymphocytes and excessive immunogenic activity of antigen presenting cells are recognised as an important pathogenic elements in allergic diseases. Successful prevention of development of these pathomechanisms determines the effectiveness of administered therapy. The aim of presented investigations was to assess the kind and the degree of immune disorders in the group of 40 patients with chronic allergic sinusitis (CAS). The range of evaluated parameters comprised the indices of immune competence of T cells in microcultures of mononuclear cells isolated from the blood (response to mitogens PHA and Con A, saturation of IL-2 receptors, T-cell suppressive activity--SAT index), indices of immunogenic activity of monocytes (LM index correlated with the ratio of concentrations of IL-1 beta/IL-1ra, concentrations of IL-1beta, IL-1ra, IL-4 and IL-6 in the culture supernatants). The results were compared with the similar estimations performed in the group of 20 healthy blood donors. RESULTS: The obtained results demonstrated significant deficiency of T cell immune competence in the group of patients suffering from CAS (hyperreactivity of non-matured T cells to Con A, decreased saturation of IL-2 receptors, deficient T-cell suppressive activity and quantitative deficiency of TCD8 cells). In contrast to that, the immunogenic activity of monocytes was significantly elevated in the group of CAS patients as compared to the control group (significantly higher values of LM index, considerable increased concentrations of IL-1b, IL-4 and IL-6). CONCLUSIONS: The observed immunoregulatory deficiency of T-cell population and increased immunogenic activity of antigen presenting cells (monocytes) in CAS patients seem to suggest that the routine antiinflammatory treatment in these patients should be supplemented with the immunocorrective therapy aimed to restore the deficient thymus-dependent immune competence.

Adult↗
PubMed2005

[Assessment of the correlation between taste and smell functioning].

UNLABELLED: There are few studies examining relationship between taste and smell. However their clinical unity is more often indicated. Smell perception abnormalities cause modification in taste of food intensity, disabling perception of taste as a consequence of taste's sniffing failure. Thus disturbances of these senses, which often commonly coexist could cause great discomfort in patients, however taste sense is estimated as less important comparing to smell sense. The aim of that study was to compare the taste perception in patients with normal smell function and patients with hyposmia and anosmia. There was analyzed correlation between the patients' subjective estimation of smell and taste senses and results of gustometry and olfactometry examinations. MATERIAL AND METHOD: there were indicated three groups of patients based on smell examination with usage of Elsberga--Levy'ego olfactometr in Pruszewicz modification. The first group included patients with normosmia, the second--patients with hyposmia or anosmia related to every smell, the third--patients with hyposmia on few smells and normal smell feeling of others. The Bornstein's method gustometry modified by us was performed for all groups. Moreover patients presented their subjective estimation of smell and taste senses. All results were statistically analyzed, taking into consideration results with alpha < or = 0.05. RESULTS: All (100%) patients with normosmia correctly identified sour, bitter and salty tastes, while only 53% of patients with hyposmia and anosmia got similar results. However 76.5% of patients from the second group subjectively estimated their sense of taste as a normal perception. CONCLUSIONS: Patients with smell disturbances significantly more often have abnormalities in taste perception than patients with normosmia and their subjective estimation of taste and smell senses is much more different than gustometry and olfactometry results.

Adult↗
PubMed2005

[Evaluation of the equilibrium system in patients with multiple sclerosis based on qualitative assessment with videonystagmography].

Multiple sclerosis (SM) is the most frequent inflammatory-demyelinating disease of central nervous system. The character of SM disease provokes that its most frequent symptoms are vertigo, equilibrium disorders and ataxia. Objective method of vertigo estimation is evaluation of the nystagmus via videonystagmography registration (VNG). This examination allows to simultaneously assess the vertical and horizontal component of the nystagmus. It is considered that mainly the vertical nystagmus is characteristic to equilibrium system impairments of the central nervous system, caused also by SM. The study was carried out on 40 patients (28 women, 12 men) with SM diagnosed as a result of neurological examination. 7 patients (17.5%) suffered from sham - movement vertigo, while 33 patients (82.5%) suffered from instability of posture and walking deviation. The videonystagmography examination resulted in the following: deviation of the eye movement was recorded in 26 patients (65%) during either in saccadic test and in smooth pursuit test, optokinetic nystagmus recorded: dissymetric and variable amplitude result in 24 patients (60%), presence of vertical nystagmus component in 30 patients (75%), positional test: directional-changable nystagmus in 8 patients (20%), pendular nystagmus in 4 patients (10%), presence of vertical nystagmus component in 31 patients (77.5%), caloric test: impairments of one of the labyrinth recorded in 12 patients (30%). SM is still the diagnostic and therapeutic problem. During the mentioned tests we have found the quantitative and qualitative changes in VNG recordings. This may be helpful in SM diagnosis, mainly during its early stages.

Adult↗
PubMed2005

[Detection of Helicobacter pylori in nasal polyps specimens using urease test GUT plus].

In patients with nasal polyps the colonisation of nasal polyps tissues by Helicobacter pylori was investigated using urease test (GUT plus). In this prospective clinical trials we enrolled 61 subjects who had undergone endoscopic nasal polyps surgery and 30 subjects who had undergone septoplasty (control group) were questioned and biopsy specimens of the removed polyps or the mucosal part of inferior turbinate were tested by the urease test GUT plus. In result Helicobacter pylori was not found in the nasal polyps and mucosal part of inferior turbinate tissue of any of patients including the 43 of 61 patients with nasal polyps and 7 of 30 patients with septum deviation who had symptoms of gastroesophageal reflux. In our study using the urease test GUT plus we were not able to confirm presence of Helicobacter pylori in the nasal polyps tissue. However, further epidemiologic studies using different diagnostic methods would be necessary to confirm presence of Helicobacter pylori as potential underlying pathogenetic mechanism of nasal polyposis.

Adult↗
PubMed2005

[Computerized image analysis in recognition and classification of aeroallergens].

UNLABELLED: In medical practice and research, it would be convenient to receive pollen identification and monitoring results in much shorter time than it comes from human identification. Image based analysis is one of the approaches to an automated identification scheme for pollens grain and pattern recognition on such images is widely used as a powerful tool. PURPOSE OF THE STUDY: The goal of such attempt is to provide accurate, fast recognition and classification and counting of pollen grains by computer system for monitoring. METHODS AND MATERIAL: The isolated pollen grain are objects extracted from microscopic image by CCD camera and PC computer under proper condition for further analysis. RESULTS: The algorithms are based on the knowledge from feature vector analysis of estimated parameters calculated from grain characteristics including morphological features, surface features and other applicable estimated characteristics. Segmentation algorithms specially tailored to pollen object characteristics provide exact descriptions of pollen characteristics (border and internal features) already used by human expert. The specific characteristics and its measures are statistically estimated for each object. Some low level statistics for estimated local and global measures of the features establish feature space. Some special care should be paid on choosing these feature and on constructing the feature space to optimize the number of subspaces for higher recognition rates in low-level classification for type differentiation of pollens grain. CONCLUSIONS: The results of estimated parameters of feature vector in low dimension space for some typical pollen types are presented as well as some effective and fast recognition results of performed experiments for different pollens. The findings show the evidence of using proper chosen estimators of tailored characteristics for good enough classification measures even for low dimensional classifiers for type differentiation of pollens grain.

Humans↗
PubMed2005

[Examination of upper airway function using the dew point hygrometer with semiconductor detector].

The nasal mucosa with blood capillary network has a remarkable role in respiration process. The most important nose functions are heating and humidifying to optimal level of reaching throat and lungs air and partly absorption of humidity and temperature from expired air. Variations of humidifying and heating processes can invoke some upper airways disorders. The paper presents dew point hygrometer which was specially design for laryngological purposes. The hygrometer can measure dynamic changes of humidity in upper airways. The device is fully automated, easy to operate and can communicate with external personal computer. Database application allows saving patient data with archive examination results and can display them easily. During ongoing clinical tests, still increasing amount of data will allow precisely investigate correlations between humidifying process and some diseases. The main advantage of the device is a short response time on humidity changing. The number of readings (detections) can reach 5 readings per second (slightly depending on humidity level) which is much faster than in available on the market hygrometers with sorption sensors. The paper also presents some results obtained in group of healthy volunteers and one patient with tracheostomy The tests figured out actual humidity in certain parts of upper airways: nose, throat, trachea in breathing cycles under various surrounding conditions. The constructed hygrometer can be used for air humidity measurement in upper airways during some diseases and for evaluation of an influence of some drugs and environmental conditions changing on air upper ways mucosa.

Adult↗
PubMed2005

[Examination of the temperature stabilization process in the upper airways using a miniaturized electronic thermometer].

Diagnostic and treatment procedures in laryngology demand the knowledge on physiological processes taking place in nasal cavities in the course of breathing. It is of special importance in treatment with pharmacologic agents exerting an influence on nasal blood vessels and in nasal structures operations. The paper presents electronic thermometer which was specially designed for measurements in human higher airways. The system is set of flexible measurement head with miniature thermistor and microprocessor system connected to the personal computer fit out database application for collect and visualization measurement data. The device is safe for medical doctor and patient as well. With patient point of view, the measurements can be done easily and comfortably. The system allows recording dynamic changes of air temperature in upper airways and recalculates average inspired and expired air temperatures. The paper presents also initial results obtained in group of 15 healthy volunteers and 3 with tracheotomy It was made an estimation nasal ability to heating inspired air in particular places of nasal cavity and determined air temperature in nasal cavity outlet.

Adult↗
PubMed2005

[Subjective and objective assessment of voice quality after surgical treatment of overgrowth changes in vocal folds].

OBJECTIVES: Complex estimation of results of treatment micro surgically of ill larynx with overgrowth changes of vocal folds and comparison of usefulness different methods of research phonation function of larynx, and also estimation of influence disturbances of voice on functional state, emotional and physical ill applying to Clinics. MATERIAL AND METHOD: With researches embraced group 40 ill with hoarseness, of which reason one was organic changes of vocal folds under form of polyps, of vocal nodes, of cyst and of swellings Reincke, attended operational (microsurgery with method Kleinsasser). Voice priced twice before intervention surgical and 3 months after operation. In researches used with scale GRBAS, with estimation laryngostroboscopy of function of vocal folds, analysis acoustic created of voice and Polish version of Voice Handicap Index (VHI). RESULTS: Values p = 0.001 for "G" and p = 0.002 for "B" testify about special usefulness these two values of scale GRBAS in estimation of efficiency used treatments. Value p = 0.0004 obtained in research VHI proves distinct statistical symptomatic between estimation one's own voice and his of influence on life ill before and after operation and about good result of treatment. Statistical analysis examined of acoustic parameters showed on indeed statistical symptomatic difference only in chance of variable RAP (p = 0.03). Greatly usefulness for estimations used treatments showed stroboscope research, where especially character close of glottis (p = 0.003) and changes of mucosal wave (p = 0.008) show distinct dependence statistical difference before and after operation. CONCLUSIONS: In complex estimation of voice ill after operation overgrowth changes of vocal folds greatest usefulness showed research of laryngostroboscopy, Voice Handicap Index (VHI) and qualification of grade-G and breathiness-B in scale GRBAS. Thanks used to method VHI ill oneself priced efficiency effect treatments, and doctor knowing answers of patient on each questions canned properly to steer further treatment.

Adult↗
PubMed2005

[Effectiveness of pharmacologic therapy combined with hyperbaric oxygen in sensorineural hearing loss following acute acoustic trauma. Preliminary report].

UNLABELLED: Exposure to loud sounds can cause acute acoustic trauma and permanent sensorineural hearing loss. The aim of the study was to evaluate effectiveness of pharmacological treatment combined with the hyperbaric oxygen (HBO) in the treatment of sensorineural hearing loss following acute acoustic trauma for patients treated in the Department of Otolaryngology of Military Institute of Health Service and Warsaw Center for Hyperbaric Therapy and Wounds Treatment. MATERIAL AND METHODS: Group of 12 patients (22 damaged ears) with acute acoustic trauma (10 men and 2 women), 16-67 years of age, mean age 28 years, was involved in our study. Patients with tinnitus and sensorineural hearing loss of minimum 15 dB at 0.25-8 kHz were included in the treatment group. Hearing gain of minimum 10 dB at 0.25-8 kHz and decrease in the intensity of tinnitus was considered as an improvement. 4 days was the mean time interval between acoustic trauma and starting the pharmacological treatment, 7 days was the mean time interval for the hyperbaric oxygen therapy commencement. RESULTS: Statistically significant difference in Pure Tone Audiometry results obtained before and after the treatment was noted in 4 kHz when considering all damaging factors that caused acoustic trauma and in 6 kHz only for damage resulting form shooting. Statistically significant difference was noted in 6 kHz if the HBO therapy was continued over 10 days (p < 0.00001). Statistically significant difference was noted in 4, 6, 8 kHz when treatment was started within 5 days since the acoustic trauma (p < 0.000001). CONCLUSIONS: Hyperbaric oxygen therapy is the unique method of increasing concentration of oxygen in the inner ear fluids thus facilitates the regeneration process. Hyperbaric oxygen therapy combined with steroids is an effective method of sensorineural hearing loss treatment following acute acoustic trauma.

Adolescent↗
PubMed2005

[Evaluation of polypectomy-related changes on olfactory function].

AIM: Aim of this study was to evaluate polypectomy-related changes of olfactory function in early postoperative period in comparison to the preoperative situation. MATERIAL AND METHODS: Olfactory function was assessed in 25 patients of Military Medical Institute using Elsberg-Levy method. Measurements were performed preoperatively and 1 month after polypectomy. RESULTS: Before the polypectomy measurements revealed higher odor thresholds in 18 patients. Postoperatively, decline of odor thresholds was observed in 14 hyposmic patients. CONCLUSION: Present data indicates that olfactory function is related to nasal obstruction resulting from nasal polyposis. The study showed that polypectomy can increase olfactory function in patients with nasal polyps. Olfactometry can help to estimate nasal polyps during and after treatment even in early stage.

Adult↗
PubMed2005

[New method of biopsy of palatine tonsils and its role in the indication for tonsillectomy (preliminary report)].

In our work we presented a new method of chronic tonsillitis diagnosis and evaluated its usefulness in qualification to tonsillectomy. Oligobiopsies were obtained from right and left palatine tonsils of 36 patients who were qualified to tonsillectomy on the basis of past medical history, otolaryngological examination and laboratory tests findings. Following gauge of biopsy instruments were used: 2 mm, 3 mm, 4 mm. The material obtained at biopsies and tonsillectomies was histopathologically evaluated. Histopathological findings of specimens obtained at oligobiopsies and post tonsillectomies were compared. The presence of interstitial fibrosis, neutrophils infiltrates, hyperplastic changes of lymphoid follicles of palatine tonsils were evaluated in oligobiopsy specimens in comparison to the results of postoperative specimen findings. Full concordance of histopathological findings obtained at oligobiopsy and post tonsillectomy was noted with the use of biopsy instruments of 3 mm and 4 mm gauge. Specimens obtained at oligobiopsies had a great diagnostic value. It was proved that the biopsy performed according to our method has a great diagnostic value and helps surgeon to qualify patient to tonsillectomy.

Adult↗
PubMed2005

[Nitric oxide as indicator of paranasal sinusitis].

Squamous cell carcinoma antigen (SCCAg) is one of the most common markers used in diagnosis of head and neck cancer and larynx cancer. We tested correlations between level of SCC Ag and tumor size, presence of lymph node metastasis, clinical advances of tumour and histopathological diagnosis. Pretreatment level of SCC antigen was evaluated in 34 patients with squamous cell carcinoma of the larynx. Microparticle enzyme immunoassay was used to measure the SCCAg level. Elevated SCCAg serum levels were found in 41% of patients. The magnitude of the marker elevations were correlated with lymph node metastases (N0 versus N2, and N1 versus N2). Our date indicate that in patients with larynx cancer SCCAg does not appear to be a sensitive marker in the primary diagnosis. However, seem to be useful marker for monitoring nodal invasion.

Adult↗
PubMed2005

[Techniques of intranasal drug use].

The aim of the study was to assess the incidence of changes in nasal mucosa in patients treated with long term intranasal corticosteroids and to determinate reasonability of intranasal drops administration in symptomatic treatment of nasal catarrh. The study included the total of 1962 patients. Within this group, 612 patients treated with intranasal corticosteroids underwent full laryngological examination to evaluate the status of nasal mucosa. In the group of 1350 users of web-based Allergologic Courier, who had used intranasal drops because of "runny nose" within last 3 months before the examination, a questionnaire survey was performed. The study results reflect poor knowledge the methods of nasal drops administration among patients, as well as low effectiveness of educational initiatives led by physicians and pharmacists. In 25 persons from 367 examined (6.81%) who used steroid spray locally, and who showed up in laryngological outpatient clinic, nasal mucosal damage was diagnosed for the first time. Mucosal damage was most frequently located in the right nasal septal mucosa--in 21 patients (5.72% of total patients) that was connected with improper nasal inhaler positioning and right hand movements directing it towards septum in the right nasal meatus. Among patients, who have remained under regular laryngological care in outpatient clinic (all of them are instructed of drug administration technique), only 5 persons (2.04%) out from 245 in the study group presented changes in nasal mucosa. No differences between changes occurrence on each side of nasal septum were found. Without proper training, only 8.52% from 1350 examined persons had been taking nasal drops in a proper manner to achieve its effectiveness.

Administration, Intranasal↗
PubMed2005

[Acute sinusitis].

The sinusitis is the term, which describes inflammation process of mucous membrane of these sinuses. Generally inflammation spreads from the nose to the paranasal sinus, so rhinosinusitis is the common name of disease. In classification of sinusitis two aspects are important--duration of signs and symptoms and changes in mucous membrane of sinus. In acute sinusitis symptoms withdraw after treatment, and mucous membrane comes back to the normal state. The most frequent bacteria's responsible for sinusitis are aerobes and among them: Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrrhalis, Streptococcus gr. A, Staphylococcus aureus, bacteria Gram (-) as well as anaerobic bacteria's. The inflammation changes of paranasal sinuses the most often enter on frontal ethmoid sinuses and then in frontal sinus, posterior ethmoid sinuses and the most seldom in sphenoid sinus. The diagnostics of sinusitis consisted of history data, otolaryngological examination, image diagnostics, bacteriological investigation, allergological diagnostics, sometimes alternatively, dentist as well as neurologist's consultations. The treatment of acute sinusitis is conservative. The aim of the treatment is control of inflammation, decrease of tissue oedema, facilitation of outflow of secretions of the nose and paranasal sinuses. We apply the antibiotics, glycocorticosteroids, decongestant drugs and mucolytic drugs. One should remember, that not treated or wrongly treated acute sinusitis can lead to chronic sinusitis or to numerous complications.

Acute Disease↗
PubMed2005

[Effectiveness of Broncho-Vaxom in prevention of recurrent upper respiratory tract infection in children].

AIM OF THE STUDY: Evaluation of effectiveness of immunostimulating treatment with Broncho-Vaxom and his influence on concentration of proinflammatory cytokines in children with recurrent upper respiratory tract infection. MATERIAL AND METHODS: The study comprised 32 children (the average age 8 years and 4 months) with recurrent upper respiratory tract infection received immunostimulating treatment with Broncho-Vaxom. 20 children (the average age 7 years and 8 months) with recurrent upper respiratory tract infection which did not receive treatment with Broncho-Vaxom consisted the control group. In all children clinical state and concentration of cytokines TNF-alpha and, IL-1beta, IL-6, IL-8 in serum was examined. Period of observation in both groups carried out 24 months. Follow-up was executed after 6 months. RESULTS: In children treated with Broncho-Vaxom statistically significant (p<0.01) decrease in frequency of occurrence as well as shortening of duration of upper respiratory tract infection were observed. In children treated with Broncho-Vaxom statistically significant (p<0.01) decrease of serum concentration of TNF-alpha and in time of observation. The statistically significant changes were not observed in serum concentrations IL-1beta in time of observation. It was statistically significant (p<0.01) affirmed the rise of serum concentration of IL-6 in time of observation, the largest growth of concentration this cytokine stepped out in 1 year of treatment. The statistically significant (p<0.01) increase of concentration cytokine IL-8 in the first year of treatment as well as statistically significant (p<0.05) decrease of concentration this cytokine after end of treatment. CONCLUSION: The treatment with Broncho-Vaxom shows the high effectiveness in prevention of recurrent upper respiratory tract infection in children as well as the influences of profitable changes in profile of serum cytokines which can impact on limitation the inflammation process in the upper respiratory tract.

Adjuvants, Immunologic↗
PubMed2004

Tumor of the neck.

Neck tumor is always an alarming symptom. Neck tumors are be divided into primary tumors and metastatic tumors. The latter may in turn be divided into tumors which come from a known primary focus and those coming from an unknown primary source. The most commonly found neck tumor takes the form of an enlarged lymph node which may be a primary or a secondary symptom of a disease developing in this area. The diagnostic methods consisted of a otolaryngological examination, laboratory examination, histopathological examination and image examination. In primary neck tumors the treatment proceedings depend on the kind of tumor. The most difficult case, however, is a neck metastasis from an unknown primary focus. In such cases, the most appropriate method of treatment appears to be a radical neck dissection. Combined radiation should be performed in those cases, in which sample tests show cancer infiltration of the node capsule or the presence of cancer plugs in the blood or lymph vessels.

Algorithms↗
PubMed2004

[Application of the fusafungine in perioperative period in patients after tonsillectomy].

The only treatment method in chronic palatine tonsillitis is the removal of tonsils (tonsillectomy). The study aimed at a clinical evaluation of postoperative fusafungine use in patients who underwent tonsillectomy. The study included 200 patients who underwent tonsillectomy for chronic palatine pyotonsillitis in the Otolaryngology Clinic of the Military Institute for the Health Services in Warsaw between 2000 and 2002. The patients were divided into two groups, each group including 100 patients: group I--patients who underwent tonsillectomy, including 67 females and 33 males, aged 16 to 52 (mean age 34.8), in whom fusafungine was used; group II--patients who underwent tonsillectomy, including 58 females and 42 males, aged 17 to 56 (mean age 36.1), who did not receive fusafungine. The subjects were observed during the first 14 days following the operation. The treatment was administered from the first day after the operation, by spraying 4 doses into the throat, 4 times a day, at 8.00 hrs, 12.00 hrs, 16.00 hrs and 20.00 hrs. The two groups were then compared in terms of: symptoms of sore throat, body temperature, swallowing difficulties, the course of healing, appearance of the pharyngeal mucosa, quality of life and general affection. Post-tonsillectomy fusafungine use was found to improve the patients' quality of life, appeases the sore throat and swallowing difficulties, decreases the need for general antibiotic therapy; the above results are statistically significant. Fusafungine was not found to influence body temperature, the appearance of the pharyngeal mucosa or the healing process.

Adolescent↗