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D Wood

Publications and source records attributed to D Wood.

At least 217 records · Page 12Linked to original sources

Causal attributions, sanctions, and normal mood variations.

The causal-locus hypothesis (CLH) asserts that persons making internal attributions for failure and external attributions for success experience more negative postoutcome moods than persons making the opposite attributions. Three experiments assessed the CLH. Although outcomes consistently affected moods and attributions, attributions did not affect moods. Significant correlations consistent with the CLH were also infrequently obtained. Another theory, the sanctioned-object hypothesis (SOH), was proposed for understanding how causal attributions lead to mood changes. This hypothesis asserts that the application of positive or negative sanctions to objects in the perceptual field is a central determinant of mood and that attributions affect mood when their content and salience activate sanctioning processes. A fourth experiment evaluated the competing theories. The results supported the SOH but not the CLH. The findings are discussed in terms of their implications for understanding mood variations and the effects that moods have on the construction of attributions and for adopting methodological alternatives that may be valuable for future laboratory research studying mood variations.

Affective Symptoms↗

The prevalence of attention deficit disorder, residual type, or minimal brain dysfunction, in a population of male alcoholic patients.

The authors assessed the prevalence of attention deficit disorder, residual type, in a population of young adult male alcoholic patients in two residential alcohol treatment programs. They found the prevalence of the disorder in this sample to be 33% and hypothesize that attention deficit disorder in childhood (and adulthood) may be associated with an increased risk for the development of alcoholism. If substantiated, this finding could be of theoretical and therapeutic importance.

Adult↗

Acyclovir.

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Acyclovir↗

Molecular cloning of seal myoglobin mRNA.

Grey seal skeletal muscle containing high levels of myoglobin was used to prepare poly(A)+ RNA. In vitro translation of this RNA produced a range of polypeptides including myoglobin. cDNA was prepared by reverse transcription of muscle poly(A)+ RNA and cloned into the plasmid pAT 153. 4% of cDNA recombinants were shown to contain myoglobin cDNA inserts. DNA sequence analysis of one clone (pSM 178) which contained a relatively large myoglobin cDNA insert showed an incomplete cDNA comprising the terminal 293 nucleotides of 3' non-translated mRNA sequences. Hybridization experiments using this myoglobin cDNA indicated that seal myoglobin is coded by a single gene which is transcribed to give a 1400 nucleotide mRNA considerably longer than related haemoglobin mRNAs.

Animals↗

Noise-induced hearing loss in rural schoolchildren.

Sixty-eight schoolchildren (mean age, 15.2 years) received audiological assessments and filled out questionnaires concerning their histories of noise exposure. Eighteen percent of this population and more than one in four males (26%) were revealed to have audiograms consistent with noise-induced hearing loss. The frequent use of guns for recreational purposes over several years was characteristic of individuals with hearing loss.

Adolescent↗

Limitation of myocardial infarct size after surgical reperfusion for acute coronary occlusion.

We investigated the effect of different forms of myocardial protection on infarct size and on the necrotic myocardial process after reperfusion for acute occlusion of the left anterior descending coronary artery (LAD) in dogs. Three control groups were formed: a 1 hour, 2 hour, and 6 hour locally ischemic control. Three experimental groups were locally ischemic for 1 hour and then reperfused after an additional hour of local ischemia on cardiopulmonary bypass with the heart protected by intermittent ischemia, cold potassium cardioplegia, or blood cardioplegia. To delineate the area at risk, the LAD was temporarily occluded 30 seconds before the 6 hour sacrifice time, and monastral blue dye was injected through a polyvinyl catheter placed in the left atrial appendage. The LAD area at risk (AR) was not stained. After 6 hours the heart was excised and treated with triphenyltetrazolium chloride (TTC) to define the area of myocardial necrosis (AN). The AN/AR ratio was determined for each animal by planimetry. Mean values were then computed in each of the six groups and evaluated by the Student's t test for paired data. The 1 hour control group had an AN/AR ratio of 64% +/- 5%; the 2 hour control group, 80% +/- 6%; and the 6 hour control group, 92% +/- 1%. The intermittent ischemia group had an AN/AR ratio of 83% +/- 2%; the crystalloid cardioplegic group (2 hours of ischemia) had a ratio of 69% +/- 4%, similar to the 1 hour control but significantly smaller than the 2 hour control (p less than 0.05); and the blood cardioplegia group had an AN/AR ratio of 48% +/- 8%, significantly better than any other group. These data demonstrate that myocardial necrosis after coronary occlusion is a time-related phenomenon and will increase to encompass a large fraction of the area at risk unless there is physical or pharmacologic modification during reperfusion, such as crystalloid or blood cardioplegia.

Animals↗

Analysis of courtship sequences of the hybrids between Drosophila melanogaster and Drosophila simulans.

Several transitions between sequential male courtship elements were analyzed for Drosophila melanogaster, its close relative D. simulans, and two types of hybrid males. Hybrid males from special reciprocal crosses did not differ. While D. melanogaster and D. simulans males differed markedly for the majority of transitions studied, hybrid males showed no consistent pattern with the parent species, being indistinguishable from D. simulans males, indistinguishable from D. melanogaster, or intermediate between them, depending on the trait observed. This suggests independent genetic control of these transitions during male courtship.

Animals↗

Linkage of adult alpha- and beta-globin genes in X. laevis and gene duplication by tetraploidization.

We have used cloned adult X. laevis alpha- and beta-globin cDNAs to analyze globin genes in X. laevis DNA. We detected alpha 1- and beta 1-globin genes which contain intervening sequences and code for the major adult globins, plus additional diverged alpha 2- and beta 2-globin genes of unknown coding potential. Unlike the case in mammals, the X. laevis alpha 1- and beta 1-globin genes are closely linked and occur in the sequence 5'-alpha 1-9 kb-beta 1-3'. The alpha 2- and beta 2-globin genes are also linked, and analysis of globin genes in X. tropicalis suggests that this duplication of an alpha-beta-globin gene pair in X. laevis is the result of chromosome duplication by tetraploidization. The close linkage of alpha- and beta-globin genes in Xenopus provides evidence that vertebrate alpha- and beta-globin genes evolved by tandem duplication of a single primordial globin gene.

Animals↗

The impact of paraprofessional alcoholism counselor training.

The present study evaluated the impact of a Navy alcoholism counselor training program. Forty-five trainees were tested before and after an intense 10-week training period at the Naval Alcohol Rehabilitation Center in San Diego. A pilot study enabled methodology refinement and selection of instruments most discriminating change over training. Based on pilot data, 12 measures were utilized: nine personality scales from a short form MMPI (Mini-Mult) and the Comrey Personality Scale, an alcoholism knowledge and attitude test, and a counseling skills effectiveness measure. Results indicate a significant positive change over training on several measures of alcoholism attitudes, knowledge. and counselor effectiveness. Significant differences were also noted on several personality scales indicating change toward the normal range. The findings suggest that the training appeared to have a significant positive impact on trainees. Some implications and limitations are discussed.

Adult↗

Systolic time intervals in monitoring for anthracycline cardiomyopathy in pediatric patients.

Systolic time intervals are of value in measuring left ventricular function. The ratio of the pre-ejection period to the left ventricular ejection time (PEP/LVET) was determined serially in 60 children with cancer receiving anthracycline drugs. Measurements were examined for their predictive value in determining incipient anthracycline cardiomyopathy. An increase in the PEP/LVET ratio was not followed by clinical failure in the majority of patients. Of two patients who developed presumed anthracycline cardiomyopathy, only one demonstrated an increase in the ratio prior to going into heart failure. The value of the PEP/LVET ratio in children for predicting anthracycline cardiomyopathy appears limited, based on the results of this study.

Adolescent↗