The genetic information contained in the Kirsten and Moloney strains of mammalian RNA-containing sarcoma viruses has been analyzed by RNA . (3)H-DNA hybridization. Kirsten sarcoma virus has been found to possess two distinct sets of nucleic acid sequences. One set of sequences is contained in murine type C helper virus, and the other set is contained in rat type C helper virus. Moloney sarcoma virus contains sequences of murine type C helper virus but not of rat type C helper virus. The results indicate that Kirsten sarcoma virus arose through a process of recombination between Kirsten murine leukemia virus and nucleic acid sequences found in rat cells. A model is suggested for the formation of transforming type C viruses involving the transduction of oncogenic information.

Animals↗

PubMed1973

Kinetics of iron deposition in rheumatoid joints.

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Arthritis, Rheumatoid↗

PubMed1973

Cytogenetic and scanning study of patients receiving intra-articular injections of gold-198 and yttrium-90.

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Arthritis, Rheumatoid↗

PubMed1973

An instrument for the analysis of direct arterial pressure recorded on magnetic tape.

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Blood Pressure Determination↗

PubMed1973

Improved function with extra-corporeal pig-liver perfusion by exclusion of cooling phase.

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Animals↗

PubMed1973

Chromosomes of tissue cultured cells from a rat breast tumour.

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Aneuploidy↗

PubMed1972

The menopause.

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Female↗

PubMed1972

Kinetic and equilibrium analysis of estradiol in uterus: a model of binding-site distribution in uterine cells.

Kinetic and equilibrium binding studies indicate that the process by which the complex of estradiol-binding protein is transferred to the cell nuclei is very rapid and is readily reversible in intact cells; that is, the cytosol and nuclear binding sites are in a rapidly reversible equilibrium. Binding of the hormone appears to shift this equilibrium such that a large percent of the filled binding sites become associated with the nuclear fraction. A model is presented to show that the quantity of filled nuclear binding sites present at any estradiol concentration can be determined strictly by the initial binding between the hormone and the cytosol binding sites.

Animals↗

PubMed1972