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Biomedical subjects

D Weinstein

Publications and source records attributed to D Weinstein.

125 records · Page 7Linked to original sources
PubMed1970

Acetylsalicylic acid: no chromosome damage in human leukocytes.

Acetylsalicylic acid was added to cultures of human leukocytes at several time periods over a wide range of concentrations (0.1 to 300.0 micrograms per milliliter). Leukocytes were also cultured from human volunteers during the ingestion of two 300-milligram tablets four times daily (2400 milligrams per day) over a 1-month period. No significant increase in chromosome aberrations was detected in vitro or in vivo.

Aspirin↗
PubMedDate not supplied

Expectant management of post-term patients: observations and outcome.

Post-term pregnancy is associated with increased perinatal mortality. In a retrospective study based on our post-term protocol from 1990 until May 1995 1,798 post-term pregnant women with reliable dating were evaluated for expectant management. A group of 2,633 pregnant women who delivered between 37 and 41 weeks during 1994 served as a control group. The perinatal mortality (0.56 per 1,000 vs. 0.75 per 1,000 in the control group) was similar in both groups. The incidence of induction of labor (7.45% vs. 7% in the control group), meconium of more than +1 (5.2% vs. 4% in the control group), shoulder dystocia (0.33% vs. 0.19%), high birthweight (> 4,500 g) (1% vs. 1%), and cesarean section rates (7.5% vs. 7% in the control group) were similar. However the fetal distress rates (11.6% vs 16%; P = .004), instrumental deliveries (10.1% vs. 13%, P = .002), and the rate of 5-minute Apgar score of less then 7 (1.1% vs. 5%, P = .000001) were found to be significantly lower in the post-date group than in the control group. We conclude that the expectant management and our intensive observation and follow-up in post-term is indicated for both mother and fetus.

Apgar Score↗
PubMedDate not supplied

Transient evoked otoacoustic emissions in newborns in the first 48 hours after birth.

Newborns are often discharged from hospital at the age of about 48 hours. At this age, transient evoked otoacoustic emissions (TEOAEs) are not necessarily recordable in all healthy newborns. In order to determine the factors which would enable the successful recording of TEOAEs before discharge to facilitate screening for hearing, 65 fullterm newborns under 48 hours of age were tested, the youngest being 10 hours old. The ears of those neonates in whom TEOAEs could not be obtained (N = 7 neonates bilaterally, 6 unilaterally) were examined otoscopically, cleaned of vernix and retested for TEOAEs. We were thus able to record in at least one ear in all neonates tested, if the ears were clean, if they were asleep and if the testing room was quiet.

Acoustic Stimulation↗
PubMedDate not supplied

An analysis of weak mutagens in the Ames assay.

Nitrosopiperidine, sodium nitrite and 1,2 epoxybutane were tested in the Ames agar incorporation assay in an attempt to establish exact criteria for detecting the activity of these weak mutagens. As regards minimum concentrations it was determined that at 500 microgram per plate a statistical analysis and several concentrations of the activating system are required in order to manifest an indication of the mutagenicity of 1,2 epoxybutane. The mutagenicity of sodium nitrite was detectable at 80 microgram/plate while nitrosopiperidine produced a 2.5-3.2 increase over background at 250 microgram/plate. It is concluded that since weak mutagenicity cannot be predicted it is advisable to utilize the maximum concentrations possible within the limits of solubility and bacterial toxicity. At the higher concentrations 1,2 epoxybutane, nitrosopiperidine and sodium nitrite produced revertant colony counts equal to 7, 17 and 62 times above background, respectively.

Animals↗
PubMedDate not supplied

Morphologic characteristics of the interaction between normal cytotrophoblasts and their malignant counterpart in the development of trophoblastic neoplasia.

OBJECTIVES: To define the biology of the tumor-host cell interaction with regard to cellular kinetics and morphologic changes during cell-cell interaction in an in vitro model of trophoblastic neoplasia. METHODS: Using a coculture in vitro system of cytotrophoblasts and choriocarcinoma cells, we investigated the cellular kinetics and the morphologic changes in these interacting cells. A fully automatic time-lapse image system was used to record phase contrast images of the cocultured cells in a tissue culture chamber. To examine cytoskeletal structure, immunofluorescent-labeled antibodies against intermediate filaments were used. Slides were examined with a confocal laser scanning microscope and subjected to computed analysis. RESULTS: The choriocarcinoma cells attract normal cytotrophoblasts using what resembles pseudopodia to engulf the latter cells and thus form slow-growing colonies. In this process, new hybrid cells are formed, which can be differentiated from their original contributors by morphologic characteristics. CONCLUSION: This phenomenon supports our previous biochemical and molecular data on the role of cell-cell interaction in the complex process of cytotrophoblast transformation and the development of gestational trophoblastic neoplasia.

Cell Communication↗