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Biomedical subjects

D Vanel

Publications and source records attributed to D Vanel.

At least 109 records · Page 6Linked to original sources
PubMed1991

Femoral infarction following intraarterial chemotherapy for osteosarcoma of the leg: a possible pitfall in magnetic resonance imaging.

Bone infarction of the distal femur is reported in two patients with osteosarcoma of the leg (1 tibia, 1 fibula) treated by preoperative chemotherapy including intraarterial chemotherapy (IAC) by Cis-platinum. Both patients were examined by magnetic resonance imaging before chemotherapy and again prior to limb salvage surgery. The location of these lesions in the distal femur must suggest bone infarction especially if the tumor has decreased in size under treatment.

Adult↗
PubMed1991

Case report 670: Chondroblastoma maxillary sinus.

A benign chondroblastoma of the left maxillary sinus developed in a 14-year-old girl. Roentgenographic examination showed an expanding, well-defined, calcified tumor. Facial and skull chondroblastomas may be related to primary or secondary centers of enchondral ossification, and therefore they may derive from the cartilage of growth plates [3]. Initial biopsy was inconclusive, but after surgical removal a histological diagnosis was made.

Adolescent↗
PubMed1991

[Choroid metastasis in a case of urothelial carcinoma metastatic from the bladder].

A 40 year old male, presented with a left choroidal metastases, 2 month after a radical cystectomy for an infiltrating transitional cell carcinoma of the bladder. This localisation was associated with disseminated metastasis which failed to respond to chemotherapy. The patient died within one month. The review of the literature confirms the poor prognosis of choroidal metastases in patients with transitional cell carcinoma of the bladder.

Adult↗
PubMed1991

Magnetic resonance imaging of the wrist.

Magnetic resonance imaging is one of the newest diagnostic techniques for evaluating the complex anatomy of the wrist. It is the only diagnostic modality that can directly depict abnormalities within the ligaments of the wrist and the TFC complex. Pathologic processes involving bone and soft tissue can also be demonstrated.

Bone and Bones↗
PubMed1989

[Diagnosis of disorders of the pharynx and larynx].

The new imaging techniques, such as computerized tomography and, more recently, magnetic resonance imaging, have thoroughly modified the diagnostic approach to tumors of the pharynx and larynx. The extension in depth of these tumors can now be directly visualized, and the key-areas (HTE space, paraglottic space, cartilages and subglottic area), which enable the best treatment to be chosen, are analyzed. These techniques are indispensable before reaching any decision on conservative surgery.

Humans↗
PubMed1989

Clinical and radiologic analysis of 13 cases of primary neuroectodermal tumors of bone.

Radiographs and clinical charts were reviewed in a series of 13 cases of primary neuroectodermal bone tumors, involving 9 males and 4 females, aged from 3 to 32 years (average: 15 years). The average delay between the onset and diagnosis was 5 months. Fever and other systemic symptoms were present in 6 cases; in 4 cases a fracture was the mode of presentation. Seven patients had metastases (4 involving bone) at the time of presentation. Only one patient is still alive after 5 years. In the 10 patients who died as a direct result of the tumor, death occured on average 8 months following diagnosis if metastases were present initially, and 36 months after the diagnosis otherwise. Tumors predominantly involved the leg (7 cases), the pelvis (2 cases), and the humerus (2 cases), the involvement being both diaphyseal and metaphyseal. The radiologic appearance is that of an aggressive, poorly demarcated tumor, with cortical destruction, periosteal reaction and soft tissue invasion. Comparison with Ewing sarcoma shows little radiologic or clinical difference, except for a poorer prognosis in neuroectodermal bone tumors. Both bone tumors may have a similar neuroectodermal origin, with Ewing sarcoma representing the undifferentiated variety.

Adolescent↗
PubMed1989

[The value of magnetic resonance imaging in the surveillance of fibromatosis. A study of 10 cases].

Retrospective study of 10 patients followed for fibromatosis after initial treatment by magnetic resonance imaging. There is a close correlation between an intense signal on weighted T2 images and tumour recurrence. Inversely, a low signal on the weighted T2 image indicated fibrotic sequelae without tumour recurrence. The examination should commence with the weighted T2 sequence. The injection of contrast medium may be an alternative.

Adult↗
PubMed1989

[Response of bone metastases to medical treatment: definition of evaluation criteria and classification trials].

Bone metastases are very frequent. Some are sensitive to the action of anticancer drugs. However, there is as yet an unsolved methodological problem in the evaluation of response to these drugs. The uniquely radiological UICC criteria are quite insufficient, in as much as they appear with a long delay and sometimes give erroneous results. In this work we give a brief review of biological and clinical knowledge about bone metastases, and we attempt to give an array of the possible evaluation criteria and their respective value. We propose as a working hypothesis a classification of responses taking into account the criteria: the urinary hydroxyproline to urinary creatinine ratio, the serum dosage of bone isoenzyme of alkaline phosphatase and propeptide of type III procollagen (P III NP), and as an essential element, an analysis of all available imaging techniques. A visual study of bone scintillation scans must precede that of radiographs and, when possible, it must be associated to computerized scintillation scanning. When metastasis are located to the pelvis, the vertebral column, or the sternum, a CT scan or better, a nuclear magnetic resonance study (IRM), is indispensable in order to have a direct measure of the tumor extension to soft tissues. Furthermore, in the case of isolated metastases, one of these imaging techniques allows a diagnostic biopsy. Finally an analysis of response at the bone level will always be associated with a measure of their duration and an evaluation of metastases to other sites.

Acid Phosphatase↗
PubMed1988

The role of magnetic resonance imaging in the evaluation of Ewing sarcoma. A report of 27 cases.

The experience with magnetic resonance imaging (MRI) in 27 patients with Ewing sarcoma is reported and compared with computed tomography (CT) and plain films. Plain radiography proved to be the best imaging method to asses probable histological diagnosis in all cases (n = 6). For the evaluation of chemotherapeutic response (n = 4), CT and MRI gave the same information about the variation in size of the tumor. In this small series, the high signal in T2 weighted images was not altered significantly by therapy. In preoperative evaluation (n = 14), MRI gave better information than CT of soft tissue involvement and extension within the bone marrow in two cases each. The ability of MRI to accurately define extension through the epiphyseal plate in two cases permitted limb salvage which otherwise would not have been possible. In the long-term follow-up (n = 12), three patients without recurrence one year after therapy showed a low signal in the surgical area in T2 weighted images. Nine patients had a high signal in T2 weighted images: four were reactive lesions, two had obvious recurrence, and one was a hematoma. In the two remaining cases plain films and CT were normal, in the presence of both active tumor and reactive lesions. It was not possible with MRI to differentiate active tumor from reactive change, even after Gd-DTPA infusion.

Adolescent↗
PubMed1988

[Experience with protocol T10 in the pediatric service at the Gustave-Roussy Institute].

Between April and September 1986, 60 patients with osteosarcoma have been treated according to the T10 protocol in the Pediatrics Department of the Gustave Roussy Institute in Villejuif, France. Limb sparing could be achieved in 49 patients and amputation was necessary in 11. The necrosis of the primary tumor was total or subtotal in 33 cases and incomplete in the 27 others. With a median follow-up of 28 months, the actuarial survival is 85% at 48 months and the actuarial disease-free survival is 58%; the disease-free survival of "good responders" is 75% and 32% for "bad responders".

Adolescent↗
PubMed1988

[Contribution of gadolinium DOTA in primary tumors of bone and soft tissue].

20 patients with a primary musculo skeletal tumor were investigated by MRI to assess the efficacy of Gd DOTA. The essential contribution is that it distinguishes the active parts of the lesion, intratumoral necrosis or sequelae cavities that do not take up the contrast medium. The injection does not allow for differentiation between tumor recurrence and treatment-induced inflammatory abnormality.

Adult↗
PubMed1988

[Imaging of sarcomas of soft tissue].

Modern imaging of soft tissue sarcomas now includes ultrasounds, CT and MRI. These new techniques allow a better evaluation of initial local extension, of the response to treatment and are able to detect local recurrences early.

Follow-Up Studies↗
PubMed1988

[Imaging of bone sarcomas].

Radiological study of bone sarcomas has been improved for the last ten years. Standard X-ray analysis is now more precise. CT and MRI are presently playing an important role for pretreatment local evaluation, assessment of treatment effectiveness and detection of recurrences.

Bone Neoplasms↗
PubMed1987

The radiological appearances of telangiectatic osteosarcoma. A study of 14 cases.

Fourteen telangiectatic osteosarcomas are reported. They are rare, clinically and radiologically aggressive lesions, involving mainly the femurs of young patients, often misdiagnosed as aneurysmal bone cysts. An explanation for a characteristic early radiological appearance consisting of regular parallel striations of the shaft is suggested.

Adolescent↗
PubMed1987

Musculoskeletal tumors: follow-up with MR imaging after treatment with surgery and radiation therapy.

Magnetic resonance (MR) imaging was used as a follow-up technique in 60 patients who underwent surgery and/or radiation therapy for primary malignant musculoskeletal tumors. MR imaging was performed on a 1.5-T imager with T1- and T2-weighted imaging sequences; MR imaging findings were confirmed by means of posttreatment surgery and histologic analysis or follow-up for at least 1 year. If a low-signal-intensity lesion was seen on T2-weighted images in a patient who had undergone radiation therapy or surgery, the patient usually did not have active tumor (sensitivity, 96%). If a high-signal-intensity lesion was seen after a patient had undergone only surgery, the patient had active tumor (six of six such cases). In patients who had undergone only radiation therapy, however, the presence of a high-signal-intensity lesion may indicate either active tumor or radiation-induced inflammatory changes. Thus, in such cases, differential diagnosis of active tumor may be difficult, if not impossible, to make from MR images.

Bone Neoplasms↗