Search PubMed⌕ Search

Biomedical subjects

D Storck

Publications and source records attributed to D Storck.

At least 37 records · Page 2Linked to original sources
PubMed1984

Inhibition by DL-alpha-difluoromethylornithine of the pokeweed mitogen-induced immunoglobulin production in cultured human lymphocytes.

The effects of DL-alpha-difluoromethylornithine (DFMeOrn), an irreversible inhibitor of L-ornithine decarboxylase, on immunoglobulin production were studied in vitro using human peripheral blood lymphocytes stimulated with pokeweed mitogen. DFMeOrn inhibits in a concentration-dependent manner the usual pokeweed mitogen-induced increases of polyamine contents (putrescine, spermidine, spermine) and of [3H]thymidine incorporation. In parallel with the reduction of polyamine content and of thymidine incorporation, IgG and IgM productions are diminished, a 70% decrease being observed at 5 mM DFMeOrn concentration. Therefore, it appears that inhibition of polyamine biosynthesis may ultimately interfere with the cellular immunologic response by blocking cell proliferation. These findings certainly deserve further consideration both under in vitro and in vivo conditions.

Cells, Cultured↗
PubMed1984

First case of acquired functional C1(-) INH deficiency: association with angioedema during Churg and Strauss vasculitis.

This report deals with the first case of acquired functional C1(-) INH deficiency with normal antigenic C1(-) INH level which was detected in a young girl with angioedema and Churg and Strauss vasculitis. This complement abnormality was associated with slightly depressed levels of CH50, C4 and C2, but a normal level of C3, and high levels of total IgE and IgM rheumatoid factors. Finally, most of these abnormalities disappeared after corticosteroid therapy and clinical improvement.

Adolescent↗
PubMed1984

[Scleroderma and pregnancy. New case and review of the literature].

A new case of the rare association of scleroderma and pregnancy is reported. The pregnancy was complicated by renal failure in the last month of gestation which was initially well controlled by anti-hypertensive therapy but then suddenly progressed to pre eclampsia with signs of foetal distress necessitating emergency caesarian section. A moderately hypotrophic child was delivered. The mother progressively recovered; diuresis and blood pressure returned to normal and the proteinuria disappeared. In the light of previously reported cases and of recent advances in our knowledge of scleroderma, especially scleroderma renal disease, the authors discuss their attitude to the management of women with scleroderma wishing to become pregnant. They review the role and place of renal biopsy in the detection of subclinical renal lesions due to the scleroderma, the presence of which would be a decisive factor in assessing the risks of pregnancy. Scleroderma renal disease is, in fact, a major contraindication to pregnancy because of the very poor foetal prognosis and the risk of maternal death due to a lethal progression of renal failure.

Abortion, Spontaneous↗
PubMed1984

Idiotypic network: possible explanation of seronegativity in a patient with rheumatoid arthritis.

In order to explain long term seronegativity in certain patients with rheumatoid arthritis (RA), we looked for the presence of anti-idiotypic antibodies against rheumatoid factors (RFs). From a patient's serum with classical but seronegative RA, we isolated a low quantity of the IgG fraction which partially recognized polyclonal RF idiotypes. The purified Fab'2 anti-idiotypic antibodies were able to inhibit up to 48% of in vitro RF production by pokeweed mitogen stimulated lymphocytes from a patient's peripheral blood with seropositive RA. The two main conclusions of this study are: (1) this single patient with seronegative RA has serum antibodies directed against RF idiotypes and (2) these anti-idiotypic antibodies could be implicated in the generation of seronegativity.

Adult↗
PubMed1983

[Value of blood lipase determination in pancreatic diseases. Comparison with blood amylase assay].

The comparative diagnostic value of plasma lipase and amylase levels was evaluated in 90 patients with various symptoms of pancreatic disease. Comparison with healthy subjects showed that the lipase assay was more sensitive than the amylase assay in patients with acute pancreatitis or post-traumatic pancreatic injury, but not in patients with chronic pancreatitis. On the other hand, acute pancreatitis can be detected earlier by measuring plasma amylase levels, owing to the rapid release of this enzyme. The relative importance of these two laboratory tests is discussed.

Amylases↗
PubMed1983

A highly conserved determinant on human rheumatoid factor idiotypes defined by a mouse monoclonal antibody.

Different human IgM rheumatoid factor (IgM RF) idiotypes have been described defined by polyclonal rabbit anti-idiotypic antibodies. These antisera do not allow clear genetic analysis of the idiotypic determinants, be they cross-reactive or private. Therefore, we tried to obtain a set of monoclonal anti-idiotypic antibodies directed against RF idiotypes. Purified IgM RF serum from a patient with classical rheumatoid arthritis was used to immunize BALB/c mice. The spleen cells were fused with Sp 2/0 Ag 14, a nonsecreting mouse myeloma cell line, and a hybrid producing monoclonal anti-idiotypic antibody was selected. The mouse antibody, an IgG1 kappa, reacts with an identical or similar determinant located on (or close to) the binding site of all tested monoclonal or polyclonal IgM RF from totally unrelated patients with Waldenströms's macroglobulinemias or rheumatoid arthritis. The monoclonal antibody also reacts with 2 rheumatoid arthritis patients' IgG RF and with a low proportion of normal polyclonal IgM without detectable RF activity. An hypothesis is proposed to explain the existence of a such highly conserved determinant on RF idiotypes.

Animals↗
PubMed1983

Plasma carnitine in women. Effects of the menstrual cycle and of oral contraceptives.

The plasma concentrations of carnitine were determined in a group of 35 women and 35 men admitted to a clinic, and in another group of 18 women during their menstrual cycle. The values found for the women (45.1 +/- 2.6 nmol/ml of free carnitine and 59.1 +/- 2.8 nmol/ml of total carnitine) were not significantly different from the values obtained in men (respectively 42.4 +/- 1.7 and 55.5 +/- 1.9 nmol/ml). No direct relationship between the free or total carnitine concentrations and the concentrations of circulating lipids could be demonstrated. During the menstrual cycle the plasma concentrations of free and total carnitine remained unchanged. Intake of oral contraceptives caused an elevation in blood triacylglycerols and decreases in the levels of luteinizing hormone, follicle-stimulating hormone, and free and total carnitine.

Adult↗
PubMed1983

[In vitro lymphocyte stimulation by the pokeweed mitogen in normal subjects and undernourished patients. Influence of ornithine salts].

The influence of different concentrations of ornithine phosphate and ornithine alpha ketoglutarate on pokeweed mitogen stimulation of immunoglobulin production in vitro was tested. Lymphocyte response of normal subjects was compared with lymphocyte response of undernourished patients. Our results indicate that IgG and IgM synthesis, under usual culture conditions of PWM stimulation, can be optimized in certain normal subjects by adding low concentrations (10(-5)M/l) of ornithine in culture medium. Moreover, in this culture system, the deficit observed in undernourished patients can be partially corrected by adding physiological (close to serum) concentrations of ornithine. More data are necessary in order to find out in vivo the effect of administration of ornithine on the immune system which is influenced by many (specially hormonal) factors.

Humans↗
PubMed1981

[Insensitivity of some rats to intraperitoneal injections of collagenase and trypsin].

In the rat peritoneal injections of collagenase or trypsin give rise to severe lesions. In our experience 20% of the animals remain intact. The frequency of lesions increases with older and heavier subjects. Moreover 25% of the rats who remained free of lesions after a first injection of collagenase resist to a second one. This shows that they are strongly protected against the enzyme. The exact nature and location of this protective mechanism are not known.

Animals↗
PubMed1979

[Corticosteroid-sensitive chemical diabetes in Horton's disease].

We report 5 cases of temporal arteritis associated with a diabetes whose good evolution under corticotherapy suggests a common pathogenesis. Several hypotheses can be formulated to explain the origin of the glycemic abnormality and to understand the way corticotherapy is effective. A moderate posology could at first have a hyperplasic effect on the insulin-secreting cells, and later on a favorable action on the vascular lesion and on an immunological disorder. Any definitive conclusion cannot be evolved yet. Only a more systematical study of the glycoregulation's abnormalities in the temporal arteritis will enable to answer the many remaining questions.

Adrenal Cortex Hormones↗
PubMed1979

[Malabsorption syndrome during the initial phase of a case of severe rheumatoid purpura].

We report a case of severe Henoch syndrome in which the first manifestation was digestive with a prolonged and important intestinal malabsorption syndrome. The clinical, radiological and histological data allow to consider a malabsorption due to lesions of the chorion and submucosa probably secondary to the allergic vasculitis. The malabsorption syndrome, confirmed by the intestinal absorption tests, the study of which must be more systematic, seems to belong to the severe and polyvisceral forms of the Schönlein-Henoch syndrome.

Abdomen, Acute↗
PubMed1979

[Grawitz's tumor and provoked hyperlipemia (author's transl)].

After reporting a case of a patient aged 69 years with an inoperable hypernephroma, in whom the presence of a polycythemia and a reduction in the provoked hyperlipemia curve was found to co-exist, the authors review the data in the published literature on the influence on the small intestine of cancers other than those in the gastro-intestinal system. Basing their comments on studies of hypernephromas, they stress that a reduction or delay in the hyperlipemia curve was found in 23 out of 28 patients. This abnormality can only be explained by hypotheses at the present time.

Adenocarcinoma↗
PubMed1978

[Real-time cross-sectional echocardiography using a mechanical sector scanner (author's transl)].

Ultrasonic one-dimensional echocardiography have proven extremely useful these last years in cardiac diagnosis. However, it allows only, structures lying along a narrow ultrasonic beam, to be visualized. In order to state more precisely the spatial relationship of the various cardiac structures, some two-dimensional systems, which displays the heart by constructing a plane image composed of many straight lines have been perfected. The authors, using such a system, specify its principal technical and clinical aspects and comment from iconographics documents and from their experience with more than 100 explorations, its advantages.

Adolescent↗
PubMed1978

[Proteasic polyseritis: effects of intraperitoneal injections of collagenase, alone or together with the administration of trypsin].

The authors showed previously that the effusions of the experimental polyseritis after intraperitoneal injections of trypsin and elastase, go from peritoneum to the pleural cavities and never from thorax to the peritoneum. The intraperitoneal injections of collagenase or of collagenase and trypsin can also cause polyseritis in the rat; but more often they provoke heavy hemorrhagic lesions of the wall of the abdomen and the diaphragm. Perforations of the diaphragm were observed in 8 rats of 32, with in 6, a intrathoracic hernia of the liver or the stomach. After the intrapleural injection of collagenase or of collagenase and trypsin, hemorrhagic lesions were seen in the thorax, but not in the abdomen. These facts are a new proof for the transdiaphragmatic propagation of the proteasic solutions injected in the peritoneum.

Abdominal Muscles↗
PubMed1977

[Familial mitral valve prolapse and syncopes caused by ventricular tachycardia].

The authors report the case of a female aged 40 who was subject to syncopal attacks, and had an apical end-systolic murmur. The presence of an idiopathic prolapse of the mitral valve was demonstrated, as well as the familial nature of the condition, and the fact that the syncopal attacks were caused by ventricular tachycardia, The case report is followed by a discussion of the cardiac arrhythmias which are likely to accompany this particular mitral lesion, the difficulties in treatment which arise, and finally the danger of sudden death by ventricular fibrillation inherent in this condition, a danger which it is stille difficult to quantify.

Adult↗
PubMed1976

[Phreno-celiac disease and merycism in adults].

In this paper are described two new examples of a peculiar semiological association of which the authors have already reported a case, and in which occured simultaneously a phreno-coeliac disease and merycism since childhood. Strong epigastric pains accompained the merycism. In these two cases, the compression of the coeliac trunk by the median arcuate ligament of the diaphragm was important; in one case existed besides a compressive stenosis of the superior mesenteric artery. After the surgical liberation of the coeliac artery and the peri-coeliac neurectomy in one case, all symptoms relieved. This good result persists after twelve months. Because of the rarity of the phreno-coeliac disease and of this type of merycism, the authors think that this association is not accidental, but the result of a new nosological association.

Adult↗