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Biomedical subjects

D Sicard

Publications and source records attributed to D Sicard.

At least 163 records · Page 9Linked to original sources
PubMed1983

[Tuberculous meningitis in adults. Prognostic factors].

Clinical and biochemical data likely to constitute prognostic factors were investigated in a retrospective study of 32 cases of tuberculous meningitis. Age appeared to be a much more important factor than the initial clinical severity of the disease and the delay of treatment. Over the age of 50 years, the mortality rate was doubled. There was no correlation between age and initial severity of the clinical picture. The number of cells and level of glucose in the CSF on admission were of no prognostic significance. CSF protein levels were higher in patients who died or developed complications than in those who made an uneventful recovery (p less than 0.05). The time required for temperature and CSF protein and glucose levels to return to normal had no prognostic value. An unfavourable or complicated course should be feared when CSF protein levels are higher than 7 g/l and in the presence of persistently low CSF glucose levels.

Adult↗
PubMed1983

[Etiology and precipitating factors of necrotizing angiitis with respiratory manifestations. 5 case reports].

Five cases of periarteritis nodosa or Churg and Strauss angeitis are reported. They all had one feature in common, their onset after desensitivity procedures, an injection of gammaglobulin or vaccination. These factors were found either at the onset or before a relapse of the disease. None of the patients had HBS antigen, which supports the hypothesis of a multiple antigenic etiology of periarteritis nodosa, some of which may cause respiratory symptoms, especially asthmatic attacks. The authors emphasise the importance of prohibiting desensitivity procedures and vaccinations in patients with severe asthma.

Adult↗
PubMed1983

[In vitro effect of rosoxacin on hospital bacteria. Results of a multicenter study].

This work reports a multicenter study of antibacterial activity of rosoxacin, a new antibacterial agent of the quinolone group. Enterobacteriaceae are very sensitive to rosoxacin (modal MIC 0,5 micrograms/ml); resistant strains are observed in all species, but more often among Serratia and Citrobacter. Pseudomonas aeruginosa is less sensitive with a maximum number of strains between 2 and 8 micrograms/ml, so it is nearly for Acinetobacter. Haemophilus are very sensitive, having MIC of 0,03 and 0,06 micrograms/ml. The spectrum of rosoxacin includes Gram positive bacteria, since the MIC of Staphylococci are similar to Enterobacteriaceae; Enterococci are less sensitive, the major part of the strains being inhibited by 4 and 8 micrograms/ml.

4-Quinolones↗
PubMed1981

Effect of active and passive immunization on the development of experimental Pseudomonas aeruginosa pyelonephritis in mice.

Experimental pyelonephritis was produced in mice by the intravenous injection of Pseudomonas aeruginosa. Immune response to infection was studied by passive hemagglutination antibody titers. Vaccination of mice with live P. aeruginosa or culture filtrates (Pseudomonas antigen) induced antibodies and resulted in a high degree of protection against death and pyelonephritis following subsequent hematogenous challenge with the homologous strain. Transfer of immune serum protected mice against death following infection with the homologous strain and with a heterologous strain. However, immune serum failed to protect mice from kidney infection by the heterologous strain. These data indicate that immune serum seemed to protect against early, overwhelming bacteremia but did not prevent a chronic course of kidney infection by a heterologous strain.

Animals↗
PubMed1981

Impairment of the growth of Plasmodium falciparum in HbEE erythrocytes.

HbE is a beta-chain mutant frequently found among inhabitants of Southeast Asia and surrounding territories. We find that Plasmodium falciparum multiplies more slowly in erythrocytes from individuals homozygous for HbE than in cells from HbA individuals. In contrast, this parasite grows normally in erythrocytes heterozygous for HbE. This is the first direct evidence that suggests what has been suspected on the basis of circumstantial data, that HbE-containing erythrocytes might be advantageous to the carrier in regions with endemic malaria.

Erythrocytes↗
PubMed1980

[Histopathological observations of experimental hematogenous infection with Pseudomonas aeruginosa in mice (author's transl)].

The effect of intravenous injection of Pseudomonas aeruginosa in mice was studied in various conditions : dose of bacteria injected (2.5 X 10(6) to 4.5 X 10(7)) , moment of necropsy (one hour to 4 months after infection), number of injections (one, two and eight). Gross and microscopic examinations of tissues included kidney, lung, spleen and liver. The frequency, the type and the time of appearance of the lesions depend upon the dose of organisms, upon the individual susceptibility of the mouse and upon the number of injections. Abscesses preferentially localised in kidneys appeared in mice that received only one injection of bacteria. They were visible to the naked eye as soon as two days after inoculation with a large dose. Granulomatous inflammatory reaction was observed in the different tissues, however it was predominantly seen in the kidney and in animals that received several injections. In the liver and the spleen hyperplasia and hypertrophy of lymphoid, myeloid, megacaryocytic and mononuclear phagocytic cells were observed. This model of experimental pyelonephritis due to P. aeruginosa seems to us useful to study the factors promoting localisation and multiplication of this organism in a tissue.

Abscess↗
PubMed1980

[Diffuse corticoid-sensitive cerebral arteritis (author's transl)].

Three cases of cerebral vascularitis are reported. This affection does not occur frequently and is often unrecognized. It can be isolated or associated with disease such as sarcoidosis, Behcet's disease, or collagen disorders (lupus erythematosus, mixed connective tissue diseases). Diagnosis is made from the evolution with transient remission, the inflammatory nature of the CSF, and the presence of segmentary narrowing on arteriography. In case of doubt an exploratory operation with biopsy is necessary. The most likely etiology is an auto-immune disturbance, and cortico-therapy has greatly improved the prognosis.

Adrenal Cortex Hormones↗