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Biomedical subjects

D Shaw

Publications and source records attributed to D Shaw.

At least 217 records · Page 12Linked to original sources
PubMed1983

A 31P topical magnetic resonance study of embryonic development in hens' eggs.

A 31P topical magnetic resonance study of whole chicken's eggs in vivo is described. Resonances from adenosine triphosphate, phosphocreatine, inorganic phosphate and phosphorous storage protein were observed. These changed in relative intensity as the embryo developed. No ill effects due to exposure to radiofrequency radiation or magnetic fields were observed. It is concluded that topical magnetic resonance can make a useful contribution to the study of embryonic development in avian eggs.

Adenosine Triphosphate↗
PubMed1983

Cardioangiography in man using iohexol and meglumine-Na diatrizoate. A comparison of hemodynamic and electrocardiographic effects.

The initial clinical experience from 5 centers in the United States with iohexol for routine cardioangiography is presented. The investigation includes 124 patients who received iohexol and 127 patients who received meglumine-Na diatrizoate. Iohexol produced a lesser degree of systemic hypotension after coronary angiography and left ventriculography than diatrizoate. No deleterious electrocardiographic changes were observed after iohexol injections. Iohexol was well tolerated by the patients and it may become a preferred contrast medium for routine clinical cardioangiography.

Adult↗
PubMed1983

Neuroepithelial tumor of the optic nerve in a horse.

A nine-year-old horse was presented with severe exophthalmos of the right eye and a large mass in the vitreal cavity. The affected globe was enucleated and two months following surgery the horse was euthanized because of spread of the tumor into the calvarium producing compression of the brain stem and neurologic signs. Examination of tumor tissue by light and electron microscopic examination showed a mixed neoplasm of primitive neuroepithelium.

Animals↗
PubMed1982

A prospective study of 18 patients with cholestasis of pregnancy.

In this prospective study we evaluate the role of serum bile acids in the investigation and management of cholestasis of pregnancy in a detailed study of 18 patients. Bile acids were the most sensitive diagnostic test. The increased incidence of fetal distress (33.3% in this series) and meconium-stained fluid (58.3%) did not correlate with very high values of bile acids in maternal serum, umbilical cord serum, or amniotic fluid. Treatment of pruritus with cholestyramine and/or phenobarbital is ineffective in this condition, induction of labor is suggested once fetal lung maturity is established.

Adolescent↗
PubMed1982

Nortriptyline and EEG sleep in depressed patients.

The effect of nortriptyline was assessed on the EEG sleep of 20 inpatients with major depressive syndrome. While 25 mg of nortriptyline had an immediate effect on REM sleep variables, relatively little influence on sleep continuity measures was noted. Subsequent administration of 75 and 100 mg of nortriptyline produced continued REM sleep suppression over several weeks. In summary, nortriptyline altered EEG sleep in a pattern similar to that of amitriptyline. REM latency and REM sleep time were consistently reduced by drug administration, while REM activity was only transiently altered as with amitriptyline. The comparison with amitriptyline showed, for the most part, similar influences on REM sleep without the sedative effects of amitriptyline.

Adult↗
PubMed1982

Colposcopy, conization, and hysterectomy practices: a current perspective.

Data from the provincial cytology program has shown a progressive increase in the number of cases of cervical carcinoma in situ detected in the general population and a doubling of disease rate in third decade women, with most of the cases now in the 25- to 29-year-old age group. The introduction of a colposcopy service has led to a significant decrease in the number of diagnostic conizations performed over a 5-year period. Conization was still used for therapy in a substantial number of women despite the availability of cryotherapy and laser surgery. Eighty-five percent of all patients undergoing cone biopsy had sever dysplasia or carcinoma in situ (CIN III) on pathological examination. In 25% of patients, the conization specimen revealed either dysplasia or carcinoma in situ extending to resection margins. During review of 2249 patients, 1174 were spared a conization and were treated by either hysterectomy, cryotherapy, or laser surgery. It would appear that, although colposcopy can reduce dramatically the number of diagnostic cone biopsies, conization will still be required for therapy in a substantial number of patients.

Adult↗
PubMed1981

The pacing industry.

Explore the source record for details and available documents.

Cardiac Pacing, Artificial↗
PubMed1981

Molar pregnancy: early diagnosis by ultrasound.

This report reviews four cases with vaginal bleeding and early ultrasound diagnosis of abnormal pregnancy before nine weeks gestation, who were followed by serial ultrasound examinations and subsequently diagnosed as hydatidiform mole. The findings support the view that hydatidiform mole may arise from a blighted ovum. It is concluded that vaginal bleeding in the first trimester should be investigated by diagnostic ultrasound, and the pregnancy by terminated if an abnormal development has been confirmed.

Adult↗
PubMed1981

31P-NMR investigation of solid tumours in the living rat.

The 31P-NMR spectra of living tumours (Walker 256 carcinosarcomas) have been obtained using surface coils and found to be unlike those of normal tissues. Contrary to expectations, their intracellular pH (measured from the chemical shift of the inorganic phosphate peak) was only slightly more acid than that of normal rat muscle, and glucose infusion did not depress it. However, when deoxyglucose was infused, the tumour intracellular pH measured from the chemical shift of the deoxyglucose-6-phosphate peak was much lower (6.44 +/- 0.02) than that measured from the phosphate peak (7.14 +/- 0.01).

Animals↗
PubMed1981

REM sleep, naps, and depression.

Continued interest in rapid eye movement (REM) sleep abnormalities in depression stimulated comparative studies on daytime naps versus nighttime sleep. In a group of 15 depressed patients, REM latencies in morning and afternoon naps were similar to the shortened REM onset at night. Although REM latency did not vary across the three times, the propensity for REM sleep appeared to be greater in the morning nap than in the afternoon nap and the early portion of nocturnal sleep. Finally, the data suggest that responders to tricyclic treatment tend to be poor sleepers during daytime naps.

Adult↗
PubMed1981

Ocular manifestations of low level phenothiazine administration to cattle.

Feeding white face Hereford cattle a high protein dietary supplement containing 1.25% phenothiazine resulted in severe corneal edema when the cattle were exposed to sunlight. The corneal edema was located in the inferior two-thirds of the cornea. In one animal a severe secondary ulcerative keratitis developed. The corneal edema resolved in about 60-90 days after the phenothiazine containing concentrate was removed and the cattle not exposed to bright sunlight.

Animal Feed↗
PubMed1980

Localization of metabolites in animals using 31P topical magnetic resonance.

High-resolution phosphorous (31P)-NMR spectra of biological molecules provide detailed information about the metabolism of living systems. Although the NMR method is non-destructive, all studies so far, with two exceptions, have been carried out on excised, perfused organs and tissues or have required some form of surgery for in situ measurements. The use of 'surface' radiofrequency coils does not require surgery, but is best suited for tissues close to the surface of the animals. We describe here 'topical magnetic resonance'--a new, non-surgical method for acquiring 31P-NMR spectra from a selected, localized place deep within an animal by modifying the main magnetic field, B0, using only static-field gradients. The method is conceptually similar to one spin-imaging method but primarily provides biochemical rather than spatial information. This new technique can be used in fundamental investigations into living systems, clinical diagnosis and the estimation of the efficacy of drug therapy.

Adenosine Triphosphate↗