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Biomedical subjects

D Shapiro

Publications and source records attributed to D Shapiro.

At least 145 records · Page 8Linked to original sources
PubMed1981

Computerized EEG as a predictor of drug response in treatment resistant schizophrenics.

Thirteen chronic schizophrenics were identified who failed to improve with physician's choice medication and 1 year of systematic treatment with a long acting phenothiazine. These patients were considered to be treatment resistant. Computer analyzed electroencephalogram (CEEG) or these treatment resistant schizophrenics was characterized by a large amount of alpha activity and less fast activity, in comparison with previous results from therapy responsive schizophrenics. The therapy resistant subjects did not display the typical neuroleptic CEEG profile following test dosages of four neuroleptics, and instead displayed CEEG profiles which more closely resembled the typical profile for psychostimulants. These findings may point to an altered metabolism, neurotransmitter defect, or other problem which alters the physiological and clinical response of therapy resistant schizophrenics to neuroleptic medication.

Adult↗
PubMed1981

The delineation of the role of entry-level occupational therapy personnel.

The role assumed by occupational therapists and occupational therapy assistants during the first year of practice was delineated as part of an examination development project. The methods used to collect and analyze data obtained from several hundred therapists, assistants, and supervisors are described. A section of the results is presented to illustrate the differences and similarities found between the two levels of personnel.

Certification↗
PubMed1980

Comparison of immunonephelometry and electroimmunoassay for estimation of plasma apolipoprotein A-I.

Immunonephelometry using a helium-neon laser as light-sources has been compared with the established technique of electroimmunoassay for estimation of plasma apolipoprotein A-I (apoA-I), the major protein component of high density lipoproteins (HDL). The within-batch coefficient of variation for immunonephelometry was 6.7% and for electroimmunoassay was 4.7%, but both methods showed similar between-batch precisions (6.9% and 7.0% respectively). Plasma from 122 subjects (62 male, 60 female) were analysed by both methods. Results showed good correlation but immunonephelometry gave consistently lower apoA-I values (mean +/- 1 S.D. = 1.32 +/- 0.25 g/l) than did electroimmunoassay (1.56 +/- 0.33 g/l). Plasma apoA-I concentrations obtained by both procedures were significantly higher (P less than 0.002) in females than in males. Both assays gave results which were highly correlated with high density lipoprotein cholesterol. Immunonephelometry is therefore considered to be satisfactory for estimation of plasma apoA-I concentration.

Apolipoproteins↗