Biomedical subjects
Publications and source records attributed to D Savoia.
Some aspects of urinary tract infection are considered. We have particularly examined the adhesion of bacteria to epithelial cells as virulence factor, the diagnosis of the site of infection, the possibility of mistakes in the diagnosis of bacterial cystitis and the relationship between infection and lithogenesis.
We valued the capacity to bind immunoglobulins (Ig) G, M and A, albumin, haptoglobin and beta-lipoproteins of human serum by 80 strains of Streptococcus pyogenes and 30 other Streptococci groups. Specific binding were observed between Streptococci belonging to group A, C and G and some serum proteins. The binding varied remarkably among strains. The elevated capacity demonstrated by some strains to absorb IgG and IgA (and in poor degree (IgM) seems particularly interesting. It seems that this binding does not depend on the growth phase of microorganisms, also if the absorption in some cases can be greater in fixed time.
23 Streptococcus sp. of different serological groups were assayed to evaluate the susceptibility to amoxycillin, erythromycin and josamycin. Inhibitory (CMI) and bactericidal (CMB) activity were compared to minimal lethal concentration (CML) observed at different times from the beginning of incubation to study the kinetic of lethal effect of the three antibiotics. Erythromycin shows an earlier bactericidal efficacy against most of the strains assayed. CMB and CML evaluated after 18 hours of incubation are generally similar, while CML against Streptococci group G, Streptococci group D assayed with macrolides and CML against alpha-haemolytic Streptococci assayed with amoxycillin are higher.
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