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D S Miller

Publications and source records attributed to D S Miller.

336 records · Page 19Linked to original sources
PubMedDate not supplied

Age at menarche of European, Afro-Caribbean and Indo-Pakistani schoolgirls living in London.

Age at menarche is reported for 1,365 European, 530 Afro-Caribbean and 282 Indo-Pakistani schoolgirls taking part in a cross-sectional anthropometric survey in the London Area Health Authorities of Kensington, Chelsea and Westminster, and Brent and Harrow, in 1980-81. Mean ages at menarche are 13.59 +/- 0.37 years (European), 13.18 +/- 0.11 years (Afro-Caribbean) and 13.06 +/- 0.20 years (Indo-Pakistani). The European value is significantly higher than those for Afro-Caribbean and Indo-Pakistani girls, and for Europeans living in the same areas of London in 1966. Social class has an effect on age at menarche in Afro-Caribbean and European girls, but not Indo-Pakistani girls, whilst family size has an effect on age at menarche in Europeans and Indo-Pakistanis.

Adolescent↗
PubMedDate not supplied

Platinate toxicity: past, present, and prospects.

Using traditional toxicologic methods, four species were studied for their qualitative and quantitative predictiveness of the toxic effects of cis-dichlorodiammineplatinum(II) in man. Of the four species studied, mouse, monkey, rat, and dog, the latter two gave the best overall results. Using an in vivo rat model, it was found that except for chloroplatinic acid, eight of the tested analogs were less nephrotoxic than the parent drug, cis-dichlorodiammineplatinum(II). The in vitro renal toxicity screen using flounder tubules showed that of the 26 compounds studied, about half were less toxic than the parent compound. This in vitro mini-tox system can be performed about 30 times faster and at one fiftieth the cost of the in vivo model. The in vitro studies also provided evidence that the biochemical site of toxicity of platihates is on ATPases. The latter studies suggested a basis for unifying the mechanistic interpretation of the toxic actions on such disparate target organs as the kidney, nerve, stomach, and inner ear.

Adenosine Triphosphatases↗
PubMedDate not supplied

The "voice" in medicine.

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National Health Insurance, United States↗
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Immunologic characterization of tumor markers in human ovarian cancer cell lines.

OBJECTIVE: The purpose of this study was to evaluate the expression of a novel autologous ovarian tumor-associated antigen in eight human ovarian tumor cell lines compared with other ovarian tumor markers and products of oncogenes. METHODS: Autologous antibodies were eluted from human ovarian tumor-membrane fragments purified in our laboratory. These antibodies react with autologous ovarian tumor-associated antigens (AOTA) and have a high degree of specificity for human ovarian tumors. They do not bind to normal ovarian or nonovarian tissues, or to nonovarian neoplastic tissues. We evaluated eight human ovarian adenocarcinoma cell lines (2008, 2774, Caov-3, OVCAR-3, PA-1, SW 626, UCI 101, and UCI 107) by indirect immunofluorescence to determine the expression of AOTA relative to the ovarian cancer tumor marker CA 125 and the products of selected oncogenes (p 53, c-neu, and c-myc). RESULTS: The patterns and intensities of immunofluorescence correlated most closely between AOTA and c-neu. For example, AOTA and c-neu were detected in all eight cell lines and displayed very strong cytoplasmic fluorescence on cell lines 2774, UCI 101, and UCI 107. CA 125 was present in the cytoplasm of four of eight cell lines. A tumor suppressor gene product, p53, exhibited a nuclear staining pattern in six of eight cell lines. CONCLUSIONS: These data suggest that AOTA and the products of the c-neu oncogene may share certain epitopes. Current studies are underway to increase our understanding of the humoral response to ovarian cancer and the possible relationship to the expression of tumor oncogene products. Further characterization of AOTA will be necessary before early diagnostic tests can be developed.

Adenocarcinoma, Papillary↗