Search PubMed⌕ Search

Biomedical subjects

D Reynolds

Publications and source records attributed to D Reynolds.

98 records · Page 6Linked to original sources
PubMedDate not supplied

The watermelon stomach: long-term outcome in patients treated with Nd:YAG laser therapy.

Watermelon stomach is an unusual cause of gastrointestinal bleeding and iron deficiency anemia. Its etiology is unknown, but it has been reported to be associated with a variety of diseases, including autoimmune disorders and cirrhosis. We report on the long-term outcome of 15 patients (13 women, 2 men) treated with neodymium-yttrium-aluminum-garnet (Nd:YAG) laser therapy. The mean age of patients at presentation was 71.6 years (range, 59 to 85 years). Fourteen patients were transfusion-dependent, requiring an average of 9.6 units of blood in the 12 months preceding diagnosis and treatment. Associated diseases included scleroderma (3 patients), mixed connective tissue disease (1 patient), history of cancer (3 patients), cryptogenic cirrhosis (3 patients), and chronic renal failure (3 patients). In 7 of 9 patients who had an antinuclear antibody test, an elevated titer greater than 1:160 in a speckled pattern was noted. Nd:YAG laser coagulation therapy was administered to all patients without complications and was successful in reducing bleeding in every case. Five patients died during the course of follow-up without signs of recurrent gastrointestinal bleeding. The remaining 10 patients have had both endoscopic and hematologic improvement during a mean follow-up period of 4.4 years from the time of initial diagnosis (range, 2 to 8 years). The 10 survivors are no longer transfusion-dependent and have stable hematocrits.

Aged↗
PubMedDate not supplied

Pharmacologic considerations and management of common endocrine disorders in women.

This article reviews the physiology and pathophysiology of selected endocrine glands. The common presenting clinical signs and symptoms are reviewed, and the initial laboratory tests that may establish the diagnosis are recommended. Diagnosis and management of hypothyroidism, hyperthyroidism, hyperparathyroidism, hypoparathyroidism, pituitary disorders, diabetes mellitus (types I and II), hypoglycemia, and disorders of the adrenal cortex are discussed. The clinical management of the most commonly encountered endocrine disorders seen in the primary care setting is described, and pharmacologic considerations are underscored.

Endocrine System Diseases↗
PubMedDate not supplied

Passively administered antibodies alleviate stunting syndrome in turkey poults.

Stunting syndrome is an enteric disease of young turkeys that results in reduced growth (stunting) of poults and impaired feed efficiency. A virus, which has been termed the stunting syndrome agent (SSA), causes stunting syndrome. In this study passive immunity was evaluated as a method of protecting poults from stunting syndrome. One-day-old poults were injected with either tryptose phosphate broth, an anti-SSA antibody preparation, or an anti-Newcastle disease virus antibody preparation before challenge by placing them into SSA-contaminated isolators or control (nonchallenge) isolators. Poults that received anti-SSA antibodies were significantly heavier (P < 0.05) and did not display as severe clinical disease compared to birds that did not receive the anti-SSA antibodies. However, the birds that received anti-SSA antibodies and were challenged were significantly lighter (P < 0.05) than birds that were not challenged. The results of this trial demonstrate that the injection of anti-SSA antibodies benefited poults undergoing stunting syndrome. The role of passive immunity, either through breeder hen vaccination or through supplying antibodies to poults artificially (i.e., at the hatchery), may have future applications in alleviating stunting syndrome.

Animals↗
PubMedDate not supplied

An investigation of two apparent cancer clusters in one community.

Two apparent cancer clusters in a single municipality were brought to public attention within a few years of each other. The clusters occurred first in a high school and later in a general hospital across the street. Analysis of the clusters was based on the comparison of the observed with the expected cancers, where the expectation of cancer occurrence was derived from data in the Ontario Cancer Registry. While the observed/expected ratios were statistically significant for the high school staff and students, these ratios were based on a very small number of cases (n = 6), and represented 4 different cancer types. The data for the hospital did not appear as excess cancer, either across age groups or in different working locations within the hospital. In addition, cancer rates were examined for the town in which the high school and hospital were located. A number of alternative explanations are discussed, as are the issues surrounding the analysis of cancer clusters in the community. We concluded that the two apparent clusters did not require further study.

Adult↗
PubMedDate not supplied

Electromagnetic compatibility study of the in-vitro interaction of wireless phones with cardiac pacemakers.

This large-scale in-vitro investigation of the interaction between hand-held wireless phones and cardiac pacemakers tested 29 pacemaker models with five different phone standards. The phones were operational and suspended on a grid above a torso simulator filled with a saline bath with the pacemaker submerged at 0.5 cm. Testing consisted of 8,296 runs, during which any interactions detected were classified by type and regularity. Only a few pacemakers were responsible for a disproportionately large number of interactions. Likewise, interactions occurred during 21% of the tests using one particular phone technology, with little or no interaction resulting from use of the other standards. Other significant factors included the relative orientation of the phone and the pacemaker case, as well as the presence or absence of an injected ECG signal. The ECG signal facilitated observation of certain forms of interaction to the extent that this study indicates the importance of including an injected ECG signal in all testing. The study also supports the recommendation to maintain a separation distance of at least 6 inches between pacemakers and wireless phones. Each pacemaker reverted to its normal operation when the phone creating an interaction was turned off. This study may be useful in ongoing efforts to define test protocols, evaluate pacemaker designs, and mitigate interactions, perhaps providing the basis for future certification and screening efforts.

Electrocardiography↗