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Biomedical subjects

D Radu

Publications and source records attributed to D Radu.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Applicability of the leukocyte migration inhibition test in the clinical practice.

The leukocyte migration inhibition test reveals in vitro the presence of lymphocyte sensitivity and, consequently, of cell-mediated immunity, to a given antigen. Applied in a variety of immune and allergic cases it proved to be useful for the positive diagnosis of the disease and/or for the detection of cell-mediated immune deficiency. The results obtained recommend the leukocyte migration inhibition test in the clinical practice.

Cell Migration Inhibition↗
PubMedDate not supplied

[Alpha 1-antitrypsin, alpha 2-macroglobulin and reactive protein C in gastric cancer].

Proteins of acute phase: alpha 1-antitrypsin (AAT), alpha 2-macroglobulin (AMG), reactive C protein (RCP) were determined in the serum of 50 patients with gastric cancer. The Mancini, simple radial immunodiffusion method was used (SRID). The concentration of these proteins increased at 32/50 (64%) for AAT; 30/50 (60%) for AMG and 33/50 (66%) for RCP. By cumulative evaluation, the positivity of serum markers increased to 88%. The importance of differential diagnosis with regard to the benign gastric lesions (adenoma, ulcer, segmentary fibrosis, before receiving the bioptic result, is emphasized.

Adenocarcinoma↗
PubMedDate not supplied

A prospective study of postacute viral hepatitis: the role of HBsAg.

Twenty-two patients with HBsAg positive acute viral hepatitis have been followed-up for two years after the acute episode. Besides the usual clinical, pathological and biological examinations, the following tests were carried out: serum HBsAg: circulating T and B lymphocytes: serum IgG, IgA, IgM: leukocyte migration test to HBsAg; serum complement: autoantibodies, rheumatoid factors, cryoglobulins, alpha-fetoprotein. Serum HBsAg persistence was correlated with some features of the acute episode: protracted clinical form: recurrences or relapses; splenomegaly; decrease of circulating T-lymphocytes; presence of lymphocyte sensibilization to HBsAg. Among the seven serum HBsAg carriers, three developed a chronic hepatitis. The state of healthy chronic HBsAg carrier was associated with high levels of serum IgA (over 300 IU/ml). A chronic hepatitis has been also diagnosed in four out of the 15 patients who cleared their serum HBsAg. The presence, on the one hand, of a chronic hepatitis among the patients who cleared their HBsAg and, on the other hand, its absence in some of the HBsAg carriers suggest that HBsAg persistence is not a sine qua non condition for the development of the chronic liver disease. The onset of autoimmune phenomena due to the disturbance of immunologic homeostasis and perhaps other genetic or environmental factors seemingly allow the perpetuation of a hepatic damage.

Acute Disease↗