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Biomedical subjects

D R Weathers

Publications and source records attributed to D R Weathers.

At least 37 records · Page 2Linked to original sources

Desquamative gingivitis: a form of cicatricial pemphigoid?

Desquamative gingivitis, a sub-epithelial vesiculo-bullous disease involving the gingiva, has been shown to have positive direct immunofluorescent findings similar to those of cicatricial pemphigoid. However, the lack of severe scarring, limitation of lesions to the anterior portion of the mouth and the tendency toward limitation of lesions to the oral mucosa over long periods of time in desquamative gingivitis, suggest that desquamative gingivitis and cicatricial pemphigoid are distinct and separate entities.

Adult↗

The oral melanotic macule.

A clinical and histologic study of eighty oral melanotic lesions which do not readily fit into recognized categories of melanotic lesions was conducted. These lesions tend to occur in the fifth decade of life and are most frequently seen on the gingiva, with the buccal mucosa and palate the next most frequent sites. The lesions are usually single, smaller than 1 cm., but they may also occur as multiple lesions. There is no sex bias, and there seems to be a number of etiologic factors. In a few cases long-term follow-up was possible. There is no indication of a tendency toward recurrence or development of malignant lesions. Histologically, none of the lesions shows atypia. Melanin pigmentation tends to be present in significant amounts in the basal-cell layer and less often in the lamina propria. There are no outstanding histologic differences among the eighty specimens. It is suggested that the term oral melanotic macule be used for these lesions, unless a specific cause can be confirmed by clinical data. Although these lesions should not be considered premalignant, it would be prudent to remove them for histologic confirmation of clinical impressions.

Adolescent↗

An unusual foreign body reaction - a case report.

This case documents the course and treatment of a severe reaction to an unusual foreign body. A tooth brush bristle was lodged in the lower anterior areas between the cuspid and lateral incisor teeth. Although the patient noted some original discomfort, severe pain and bone destruction did not occur until 6 weeks after the original symptoms began. Treatment involved full thickness flap reflection of the involved area. The histologic examination showed a typical foreign body reaction to the bristle. All teeth remained vital throughout the disease process and healing phase. Healing was uneventful and the lost bone completely regenerated.

Adult↗

The labial melanotic macule.

Fifty-five cases of a melanotic lesion of the lips which is well known, but not well described, are reported. The lesions characteristically occur on the lower lips of young adults. Males and females are equally affected. These lesions may be ephelides, postinflammatory melanoses, or unique lesions for which there is no exact cutaneous counterpart. We suggest the term labial melanotic macule as a descriptive one which would encompass the three different constituent entities. On the basis of follow-up information obtained and the histopathologic character of the lesions, this entity is benign and does not, in our opinion, have any malignant potential.

Adolescent↗

Palatal erythema: another etiologic factor.

The authors present three cases which created diagnostic problems. The etiology of these is, in the authors' experience, unique and not generally known. It is suggested that this etiology be considered whenever palatal erythema, ecchymoses, or petechiae are seen.

Adult↗